Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data

Tiphanie P. Vogel; Karina A. Top; Christos Karatzios; David C. Hilmers; Lorena I. Tapia; Pamela Moceri; Lisa Giovannini-Chami; Nicholas Wood; Rebecca E. Chandler; Nicola P. Klein; Elizabeth P. Schlaudecker; M. Cecilia Poli; Eyal Muscal; Flor M. Munoz

doi:10.1016/j.vaccine.2021.01.054

Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data

Tiphanie P. Vogel, Karina A. Top, Christos Karatzios, David C. Hilmers, Lorena I. Tapia, Pamela Moceri, Lisa Giovannini-Chami, Nicholas Wood, Rebecca E. Chandler, Nicola P. Klein, Elizabeth P. Schlaudecker, M. Cecilia Poli, Eyal Muscal, Flor M. Munoz

Medicine

Research output: Contribution to journal › Review article › peer-review

183 Citations (Scopus)

Abstract

This is a Brighton Collaboration Case Definition of the term “Multisystem Inflammatory Syndrome in Children and Adults (MIS-C/A)” to be utilized in the evaluation of adverse events following immunization. The case definition was developed by topic experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) in the context of active development of vaccines for SARS-CoV-2. The format of the Brighton Collaboration was followed, including an exhaustive review of the literature, to develop a consensus definition and defined levels of certainty. The document underwent peer review by the Brighton Collaboration Network and by selected expert external reviewers prior to submission. The comments of the reviewers were taken into consideration and edits incorporated into this final manuscript.

Original language	English
Pages (from-to)	3037-3049
Number of pages	13
Journal	Vaccine
Volume	39
Issue number	22
DOIs	https://doi.org/10.1016/j.vaccine.2021.01.054
Publication status	Published - May 21 2021

Bibliographical note

Funding Information:
The authors are grateful for the support and helpful comments provided by the Brighton Collaboration and SPEAC Steering Committee (Barbara Law) and reference peer review group, as well as other experts consulted as part of the process, including Drs. Marco Cattalini and Andrea Taddio for sharing unpublished cohort information. The authors are also grateful to Matt Dudley of the Brighton Collaboration Secretariat for revisions of the final document. We acknowledge the financial support provided by the Coalition for Epidemic Preparedness Innovations (CEPI) for our work under a service order entitled Safety Platform for Emergency vACcines (SPEAC) Project with the Brighton Collaboration, a program of the Task Force for Global Health, Decatur, GA.

Funding Information:
The authors are grateful for the support and helpful comments provided by the Brighton Collaboration and SPEAC Steering Committee (Barbara Law) and reference peer review group, as well as other experts consulted as part of the process, including Drs. Marco Cattalini and Andrea Taddio for sharing unpublished cohort information. The authors are also grateful to Matt Dudley of the Brighton Collaboration Secretariat for revisions of the final document. We acknowledge the financial support provided by the Coalition for Epidemic Preparedness Innovations (CEPI) for our work under a service order entitled Safety Platform for Emergency vACcines (SPEAC) Project with the Brighton Collaboration, a program of the Task Force for Global Health, Decatur, GA.

Publisher Copyright:
© 2021 The Author(s)

ASJC Scopus Subject Areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.vaccine.2021.01.054

Cite this

Vogel, T. P., Top, K. A., Karatzios, C., Hilmers, D. C., Tapia, L. I., Moceri, P., Giovannini-Chami, L., Wood, N., Chandler, R. E., Klein, N. P., Schlaudecker, E. P., Poli, M. C., Muscal, E., & Munoz, F. M. (2021). Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine, 39(22), 3037-3049. https://doi.org/10.1016/j.vaccine.2021.01.054

Vogel, TP, Top, KA, Karatzios, C, Hilmers, DC, Tapia, LI, Moceri, P, Giovannini-Chami, L, Wood, N, Chandler, RE, Klein, NP, Schlaudecker, EP, Poli, MC, Muscal, E & Munoz, FM 2021, 'Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data', Vaccine, vol. 39, no. 22, pp. 3037-3049. https://doi.org/10.1016/j.vaccine.2021.01.054

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abstract = "This is a Brighton Collaboration Case Definition of the term “Multisystem Inflammatory Syndrome in Children and Adults (MIS-C/A)” to be utilized in the evaluation of adverse events following immunization. The case definition was developed by topic experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) in the context of active development of vaccines for SARS-CoV-2. The format of the Brighton Collaboration was followed, including an exhaustive review of the literature, to develop a consensus definition and defined levels of certainty. The document underwent peer review by the Brighton Collaboration Network and by selected expert external reviewers prior to submission. The comments of the reviewers were taken into consideration and edits incorporated into this final manuscript.",

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note = "Funding Information: The authors are grateful for the support and helpful comments provided by the Brighton Collaboration and SPEAC Steering Committee (Barbara Law) and reference peer review group, as well as other experts consulted as part of the process, including Drs. Marco Cattalini and Andrea Taddio for sharing unpublished cohort information. The authors are also grateful to Matt Dudley of the Brighton Collaboration Secretariat for revisions of the final document. We acknowledge the financial support provided by the Coalition for Epidemic Preparedness Innovations (CEPI) for our work under a service order entitled Safety Platform for Emergency vACcines (SPEAC) Project with the Brighton Collaboration, a program of the Task Force for Global Health, Decatur, GA. Funding Information: The authors are grateful for the support and helpful comments provided by the Brighton Collaboration and SPEAC Steering Committee (Barbara Law) and reference peer review group, as well as other experts consulted as part of the process, including Drs. Marco Cattalini and Andrea Taddio for sharing unpublished cohort information. The authors are also grateful to Matt Dudley of the Brighton Collaboration Secretariat for revisions of the final document. We acknowledge the financial support provided by the Coalition for Epidemic Preparedness Innovations (CEPI) for our work under a service order entitled Safety Platform for Emergency vACcines (SPEAC) Project with the Brighton Collaboration, a program of the Task Force for Global Health, Decatur, GA. Publisher Copyright: {\textcopyright} 2021 The Author(s)",

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AU - Karatzios, Christos

AU - Hilmers, David C.

AU - Tapia, Lorena I.

AU - Moceri, Pamela

AU - Giovannini-Chami, Lisa

AU - Wood, Nicholas

AU - Chandler, Rebecca E.

AU - Klein, Nicola P.

AU - Schlaudecker, Elizabeth P.

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Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

Access to Document

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