Abstract
Myocardial triacylglycerol (TAG) constitutes a highly dynamic fatty acid (FA) storage pool that can be used for an energy reserve in the cardiomyocyte. However, derangements in myocardial TAG metabolism and accumulation are commonly associated with cardiac disease, suggesting an important role of intramyocardial TAG turnover in the regulation of cardiac function. In cardiomyocytes, TAG is synthesized by acyltransferases and phosphatases at the sarcoplasmic reticulum and mitochondrial membrane and then packaged into cytosolic lipid droplets for temporary storage or into lipoproteins for secretion. A complex interplay among lipases, lipase regulatory proteins, and lipid droplet scaffold proteins leads to the controlled release of FAs from the cardiac TAG pool for subsequent mitochondrial β-oxidation and energy production. With the identification and characterization of proteins involved in myocardial TAG metabolism as well as the identification of the importance of cardiac TAG turnover, it is now evident that adequate regulation of myocardial TAG metabolism is critical for both cardiac energy metabolism and function. In this article, we review the current understanding of myocardial TAG metabolism and discuss the potential role of myocardial TAG turnover in cardiac health and disease.This article is part of a Special Issue entitled "Focus on Cardiac Metabolism".
Original language | English |
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Pages (from-to) | 101-110 |
Number of pages | 10 |
Journal | Journal of Molecular and Cellular Cardiology |
Volume | 55 |
Issue number | 1 |
DOIs | |
Publication status | Published - Feb 2013 |
Externally published | Yes |
Bibliographical note
Funding Information:This work was supported by grants from the Canadian Institute of Health Research and the Heart and Stroke Foundation of Canada to J.R.B.D., post-doctoral fellowships from the Heart and Stroke Foundation of Canada and the Canadian Diabetes Association to P.C.K., Alberta Innovates ‐ Health Solutions post-doctoral awards to P.C.K. and T.P., and graduate studentship awards from the Mazankowski Alberta Heart Institute , Alberta Innovates ‐ Health Solutions , and the Canadian Diabetes Association to J.N.
ASJC Scopus Subject Areas
- Molecular Biology
- Cardiology and Cardiovascular Medicine
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review