Necroptosis mediates the antineoplastic effects of the soluble fraction of polysaccharide from red wine in Walker-256 tumor-bearing rats

Maria Carolina Stipp; Iglesias de Lacerda Bezerra; Claudia Rita Corso; Francislaine A. dos Reis Livero; Luiz Alexandre Lomba; Adriana Rute Cordeiro Caillot; Aleksander Roberto Zampronio; José Ederaldo Queiroz-Telles; Giseli Klassen; Edneia A.S. Ramos; Guilherme Lanzi Sassaki; Alexandra Acco

doi:10.1016/j.carbpol.2016.12.047

Necroptosis mediates the antineoplastic effects of the soluble fraction of polysaccharide from red wine in Walker-256 tumor-bearing rats

Maria Carolina Stipp, Iglesias de Lacerda Bezerra, Claudia Rita Corso, Francislaine A. dos Reis Livero, Luiz Alexandre Lomba, Adriana Rute Cordeiro Caillot, Aleksander Roberto Zampronio, José Ederaldo Queiroz-Telles, Giseli Klassen, Edneia A.S. Ramos, Guilherme Lanzi Sassaki, Alexandra Acco

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Polysaccharides are substances that modify the biological response to several stressors. The present study investigated the antitumor activity of the soluble fraction of polysaccharides (SFP), extracted from cabernet franc red wine, in Walker-256 tumor-bearing rats. The monosaccharide composition had a complex mixture, suggesting the presence of arabinoglactans, mannans, and pectins. Treatment with SFP (30 and 60 mg/kg, oral) for 14 days significantly reduced the tumor weight and volume compared with controls. Treatment with 60 mg/kg SFP reduced blood monocytes and neutrophils, reduced the tumor activity of N-acetylglucosaminidase, myeloperoxidase, and nitric oxide, increased blood lymphocytes, and increased the levels of tumor necrosis factor α (TNF-α) in tumor tissue. Treatment with SFP also induced the expression of the cell necroptosis-related genes Rip1 and Rip3. The antineoplastic effect of SFP appears to be attributable to its action on the immune system by controlling the tumor microenvironment and stimulating TNF-α production, which may trigger the necroptosis pathway.

Original language	English
Pages (from-to)	123-133
Number of pages	11
Journal	Carbohydrate Polymers
Volume	160
DOIs	https://doi.org/10.1016/j.carbpol.2016.12.047
Publication status	Published - Mar 15 2017
Externally published	Yes

Bibliographical note

Funding Information:
The authors would like to thank the Brazilian funding agencies CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) for financial support, and Eliana Rezende Adami, Jonathan Paulo Agnes, Flavia Caroline Collere, Thaissa Backes dos Santos, Caroline M. Kopruszinski and Renata Cristine dos Reis for the inestimable help in the experiments. We also thank the UFPR Electron Microscopy Center – CME/UFPR, Multi-User Center Confocal Microscopy of UFPR, and UFPR NMR Center.

Publisher Copyright:
© 2016 Elsevier Ltd

ASJC Scopus Subject Areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/j.carbpol.2016.12.047

Cite this

Stipp, M. C., Bezerra, I. D. L., Corso, C. R., dos Reis Livero, F. A., Lomba, L. A., Caillot, A. R. C., Zampronio, A. R., Queiroz-Telles, J. E., Klassen, G., Ramos, E. A. S., Sassaki, G. L., & Acco, A. (2017). Necroptosis mediates the antineoplastic effects of the soluble fraction of polysaccharide from red wine in Walker-256 tumor-bearing rats. Carbohydrate Polymers, 160, 123-133. https://doi.org/10.1016/j.carbpol.2016.12.047

Stipp, MC, Bezerra, IDL, Corso, CR, dos Reis Livero, FA, Lomba, LA, Caillot, ARC, Zampronio, AR, Queiroz-Telles, JE, Klassen, G, Ramos, EAS, Sassaki, GL & Acco, A 2017, 'Necroptosis mediates the antineoplastic effects of the soluble fraction of polysaccharide from red wine in Walker-256 tumor-bearing rats', Carbohydrate Polymers, vol. 160, pp. 123-133. https://doi.org/10.1016/j.carbpol.2016.12.047

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title = "Necroptosis mediates the antineoplastic effects of the soluble fraction of polysaccharide from red wine in Walker-256 tumor-bearing rats",

abstract = "Polysaccharides are substances that modify the biological response to several stressors. The present study investigated the antitumor activity of the soluble fraction of polysaccharides (SFP), extracted from cabernet franc red wine, in Walker-256 tumor-bearing rats. The monosaccharide composition had a complex mixture, suggesting the presence of arabinoglactans, mannans, and pectins. Treatment with SFP (30 and 60 mg/kg, oral) for 14 days significantly reduced the tumor weight and volume compared with controls. Treatment with 60 mg/kg SFP reduced blood monocytes and neutrophils, reduced the tumor activity of N-acetylglucosaminidase, myeloperoxidase, and nitric oxide, increased blood lymphocytes, and increased the levels of tumor necrosis factor α (TNF-α) in tumor tissue. Treatment with SFP also induced the expression of the cell necroptosis-related genes Rip1 and Rip3. The antineoplastic effect of SFP appears to be attributable to its action on the immune system by controlling the tumor microenvironment and stimulating TNF-α production, which may trigger the necroptosis pathway.",

author = "Stipp, {Maria Carolina} and Bezerra, {Iglesias de Lacerda} and Corso, {Claudia Rita} and {dos Reis Livero}, {Francislaine A.} and Lomba, {Luiz Alexandre} and Caillot, {Adriana Rute Cordeiro} and Zampronio, {Aleksander Roberto} and Queiroz-Telles, {Jos{\'e} Ederaldo} and Giseli Klassen and Ramos, {Edneia A.S.} and Sassaki, {Guilherme Lanzi} and Alexandra Acco",

note = "Funding Information: The authors would like to thank the Brazilian funding agencies CAPES (Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior) and CNPq (Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico) for financial support, and Eliana Rezende Adami, Jonathan Paulo Agnes, Flavia Caroline Collere, Thaissa Backes dos Santos, Caroline M. Kopruszinski and Renata Cristine dos Reis for the inestimable help in the experiments. We also thank the UFPR Electron Microscopy Center – CME/UFPR, Multi-User Center Confocal Microscopy of UFPR, and UFPR NMR Center. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

year = "2017",

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doi = "10.1016/j.carbpol.2016.12.047",

language = "English",

volume = "160",

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journal = "Carbohydrate Polymers",

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T1 - Necroptosis mediates the antineoplastic effects of the soluble fraction of polysaccharide from red wine in Walker-256 tumor-bearing rats

AU - Stipp, Maria Carolina

AU - Bezerra, Iglesias de Lacerda

AU - Corso, Claudia Rita

AU - dos Reis Livero, Francislaine A.

AU - Lomba, Luiz Alexandre

AU - Caillot, Adriana Rute Cordeiro

AU - Zampronio, Aleksander Roberto

AU - Queiroz-Telles, José Ederaldo

AU - Klassen, Giseli

AU - Ramos, Edneia A.S.

AU - Sassaki, Guilherme Lanzi

AU - Acco, Alexandra

N1 - Funding Information: The authors would like to thank the Brazilian funding agencies CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) for financial support, and Eliana Rezende Adami, Jonathan Paulo Agnes, Flavia Caroline Collere, Thaissa Backes dos Santos, Caroline M. Kopruszinski and Renata Cristine dos Reis for the inestimable help in the experiments. We also thank the UFPR Electron Microscopy Center – CME/UFPR, Multi-User Center Confocal Microscopy of UFPR, and UFPR NMR Center. Publisher Copyright: © 2016 Elsevier Ltd

PY - 2017/3/15

Y1 - 2017/3/15

N2 - Polysaccharides are substances that modify the biological response to several stressors. The present study investigated the antitumor activity of the soluble fraction of polysaccharides (SFP), extracted from cabernet franc red wine, in Walker-256 tumor-bearing rats. The monosaccharide composition had a complex mixture, suggesting the presence of arabinoglactans, mannans, and pectins. Treatment with SFP (30 and 60 mg/kg, oral) for 14 days significantly reduced the tumor weight and volume compared with controls. Treatment with 60 mg/kg SFP reduced blood monocytes and neutrophils, reduced the tumor activity of N-acetylglucosaminidase, myeloperoxidase, and nitric oxide, increased blood lymphocytes, and increased the levels of tumor necrosis factor α (TNF-α) in tumor tissue. Treatment with SFP also induced the expression of the cell necroptosis-related genes Rip1 and Rip3. The antineoplastic effect of SFP appears to be attributable to its action on the immune system by controlling the tumor microenvironment and stimulating TNF-α production, which may trigger the necroptosis pathway.

AB - Polysaccharides are substances that modify the biological response to several stressors. The present study investigated the antitumor activity of the soluble fraction of polysaccharides (SFP), extracted from cabernet franc red wine, in Walker-256 tumor-bearing rats. The monosaccharide composition had a complex mixture, suggesting the presence of arabinoglactans, mannans, and pectins. Treatment with SFP (30 and 60 mg/kg, oral) for 14 days significantly reduced the tumor weight and volume compared with controls. Treatment with 60 mg/kg SFP reduced blood monocytes and neutrophils, reduced the tumor activity of N-acetylglucosaminidase, myeloperoxidase, and nitric oxide, increased blood lymphocytes, and increased the levels of tumor necrosis factor α (TNF-α) in tumor tissue. Treatment with SFP also induced the expression of the cell necroptosis-related genes Rip1 and Rip3. The antineoplastic effect of SFP appears to be attributable to its action on the immune system by controlling the tumor microenvironment and stimulating TNF-α production, which may trigger the necroptosis pathway.

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AN - SCOPUS:85008195107

SN - 0144-8617

VL - 160

SP - 123

EP - 133

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

ER -

Necroptosis mediates the antineoplastic effects of the soluble fraction of polysaccharide from red wine in Walker-256 tumor-bearing rats

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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