Nerve growth factor phase shifts circadian activity rhythms in Syrian hamsters

Keshavan G. Bina; Benjamin Rusak

doi:10.1016/S0304-3940(96)12432-0

Nerve growth factor phase shifts circadian activity rhythms in Syrian hamsters

Keshavan G. Bina, Benjamin Rusak

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Nerve growth factor (NGF) receptors are found in high density in the rodent suprachiasmatic nucleus (SCN), a site which regulates mammalian circadian rhythms. We examined the effects of NGF (40 ng) or vehicle injections into the SCN, at circadian times (CT) 6, 14 or 22 on activity rhythms in hamsters maintained in constant darkness. NGF caused phase advances at CT6 (30.9 min) and CT22 (36.9 min), and phase delays at CT14 (31.2 min). Saline and cytochrome-c administration had no phase-shifting effects at CT6 and CT22, but at CT14 cytochrome-c produced large phase delays, implying that NGF-induced delays at this phase may be non-specific. Similarities between NGF-induced shifts and those elicited by the cholinergic agonist carbachol suggest a common mode of action.

Original language	English
Pages (from-to)	97-100
Number of pages	4
Journal	Neuroscience Letters
Volume	206
Issue number	2-3
DOIs	https://doi.org/10.1016/S0304-3940(96)12432-0
Publication status	Published - Mar 15 1996

Bibliographical note

Funding Information:
This research was supported by grants from NSERC of Canada (A0305) and the US AFOSR (F49620--93-1-0089). We are grateful to Donna Goguen for her excellent technical assistance.

ASJC Scopus Subject Areas

General Neuroscience

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

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10.1016/S0304-3940(96)12432-0

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title = "Nerve growth factor phase shifts circadian activity rhythms in Syrian hamsters",

abstract = "Nerve growth factor (NGF) receptors are found in high density in the rodent suprachiasmatic nucleus (SCN), a site which regulates mammalian circadian rhythms. We examined the effects of NGF (40 ng) or vehicle injections into the SCN, at circadian times (CT) 6, 14 or 22 on activity rhythms in hamsters maintained in constant darkness. NGF caused phase advances at CT6 (30.9 min) and CT22 (36.9 min), and phase delays at CT14 (31.2 min). Saline and cytochrome-c administration had no phase-shifting effects at CT6 and CT22, but at CT14 cytochrome-c produced large phase delays, implying that NGF-induced delays at this phase may be non-specific. Similarities between NGF-induced shifts and those elicited by the cholinergic agonist carbachol suggest a common mode of action.",

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Nerve growth factor phase shifts circadian activity rhythms in Syrian hamsters

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

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