Nitric oxide-mediated cGMP production in the islands of Calleja in the rat

J. De Vente; D. A. Hopkins; M. Markerink-Van Ittersum; H. W.M. Steinbusch

doi:10.1016/S0006-8993(98)00099-7

Nitric oxide-mediated cGMP production in the islands of Calleja in the rat

J. De Vente, D. A. Hopkins, M. Markerink-Van Ittersum, H. W.M. Steinbusch

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

cGMP-immunostaining in the islands of Calleja (ICj) in slices incubated in vitro partially co-localized with nitric oxide synthase (NOS) inside the ICj. No cGMP-immunostaining was found outside the ICj in unstimulated slices, whereas the NO-donor sodium nitroprusside (SNP) stimulated cGMP in cells and fibers bordering on the ICj. These findings show an ongoing NO synthesis in in vitro slices and suggest a relatively restricted diffusion range for endogenously synthesized NO.

Original language	English
Pages (from-to)	175-178
Number of pages	4
Journal	Brain Research
Volume	789
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(98)00099-7
Publication status	Published - Apr 6 1998

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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abstract = "cGMP-immunostaining in the islands of Calleja (ICj) in slices incubated in vitro partially co-localized with nitric oxide synthase (NOS) inside the ICj. No cGMP-immunostaining was found outside the ICj in unstimulated slices, whereas the NO-donor sodium nitroprusside (SNP) stimulated cGMP in cells and fibers bordering on the ICj. These findings show an ongoing NO synthesis in in vitro slices and suggest a relatively restricted diffusion range for endogenously synthesized NO.",

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AU - Markerink-Van Ittersum, M.

AU - Steinbusch, H. W.M.

PY - 1998/4/6

Y1 - 1998/4/6

N2 - cGMP-immunostaining in the islands of Calleja (ICj) in slices incubated in vitro partially co-localized with nitric oxide synthase (NOS) inside the ICj. No cGMP-immunostaining was found outside the ICj in unstimulated slices, whereas the NO-donor sodium nitroprusside (SNP) stimulated cGMP in cells and fibers bordering on the ICj. These findings show an ongoing NO synthesis in in vitro slices and suggest a relatively restricted diffusion range for endogenously synthesized NO.

AB - cGMP-immunostaining in the islands of Calleja (ICj) in slices incubated in vitro partially co-localized with nitric oxide synthase (NOS) inside the ICj. No cGMP-immunostaining was found outside the ICj in unstimulated slices, whereas the NO-donor sodium nitroprusside (SNP) stimulated cGMP in cells and fibers bordering on the ICj. These findings show an ongoing NO synthesis in in vitro slices and suggest a relatively restricted diffusion range for endogenously synthesized NO.

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Nitric oxide-mediated cGMP production in the islands of Calleja in the rat

Abstract

ASJC Scopus Subject Areas

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