TY - JOUR
T1 - NMDA-evoked adenosine release from rat cortex does not require the intermediate formation of nitric oxide
AU - Craig, Constance G.
AU - White, Thomas D.
PY - 1993/8/20
Y1 - 1993/8/20
N2 - Excitatory amino acids (EAAs) such as glutamate release the inhibitory neuromodulator adenosine from superfused rat cortical slices through the activation of both NMDA and non-NMDA EAA receptors. This study investigated the possibility that NMDA-evoked adenosine release may involve the intermediate formation of nitric oxide (NO). However, sodium nitroprusside did not evoke the release of adenosine, l-arginine did not augment and l-Nv-nitroarginine did not diminish NMDA-evoked adenosine release. It appears, therefore, that NMDA-evoked NO formation does not play a role in NMDA-evoked adenosine release in the cortex.
AB - Excitatory amino acids (EAAs) such as glutamate release the inhibitory neuromodulator adenosine from superfused rat cortical slices through the activation of both NMDA and non-NMDA EAA receptors. This study investigated the possibility that NMDA-evoked adenosine release may involve the intermediate formation of nitric oxide (NO). However, sodium nitroprusside did not evoke the release of adenosine, l-arginine did not augment and l-Nv-nitroarginine did not diminish NMDA-evoked adenosine release. It appears, therefore, that NMDA-evoked NO formation does not play a role in NMDA-evoked adenosine release in the cortex.
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U2 - 10.1016/0304-3940(93)90255-J
DO - 10.1016/0304-3940(93)90255-J
M3 - Article
C2 - 8233091
AN - SCOPUS:0027279703
SN - 0304-3940
VL - 158
SP - 167
EP - 169
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -