No effect of preterm birth on the risk of multiple sclerosis: A population based study

Sreeram V. Ramagopalan; William Valdar; David A. Dyment; Gabriele C. DeLuca; Sarah Michelle Orton; Irene M. Yee; Maria Criscuoli; George C. Ebers; A. Dessa Dessa; V. Devonshire; P. Rieckmann; S. A. Hashimoto; J. Hooge; L. Kastrukoff; J. J.F. Oger; J. P. Smythe; A. Traboulsee; P. Smyth; L. Metz; S. Warren; W. Hader; K. Knox; G. Rice; M. Kremenchutzky; M. Freedman; D. Brunet; P. O'Connor; T. Gray; M. Hohol; P. Duquette; Y. Lapierre; T. J. Murray; V. Bhan; C. Maxner; M. Stefanelli

doi:10.1186/1471-2377-8-30

No effect of preterm birth on the risk of multiple sclerosis: A population based study

Sreeram V. Ramagopalan, William Valdar, David A. Dyment, Gabriele C. DeLuca, Sarah Michelle Orton, Irene M. Yee, Maria Criscuoli, George C. Ebers, A. Dessa Dessa, V. Devonshire, P. Rieckmann, S. A. Hashimoto, J. Hooge, L. Kastrukoff, J. J.F. Oger, J. P. Smythe, A. Traboulsee, P. Smyth, L. Metz, S. WarrenW. Hader, K. Knox, G. Rice, M. Kremenchutzky, M. Freedman, D. Brunet, P. O'Connor, T. Gray, M. Hohol, P. Duquette, Y. Lapierre, T. J. Murray, V. Bhan, C. Maxner, M. Stefanelli

Medicine

Medicine

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Abstract

Background: Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. A clear parent of origin effect has been shown in several populations, perhaps resulting from factors operating during gestation. Preterm birth (birth at less than 37 weeks gestational age) has been shown to result in long-term health problems, including impaired neurological development. Here, in a population-based cohort, we investigate whether preterm birth increases the risk to subsequently develop MS. Methods: We identified 6585 MS index cases and 2509 spousal controls with preterm birth information from the Canadian Collaborative Project on Genetic Susceptibility to MS. Rates of individuals born preterm were compared for index cases and controls. Results: There were no significant differences between cases and controls with respect to preterm births. 370 (5.6%) MS index cases and 130 (5.2%) spousal controls were born preterm, p = 0.41. Conclusion: Preterm birth does not appear to contribute to MS aetiology. Other factors involved in foetal and early development need to be explored to elucidate the mechanism of the increased risk conferred by the apparent maternal effect.

Original language	English
Article number	30
Journal	BMC Neurology
Volume	8
DOIs	https://doi.org/10.1186/1471-2377-8-30
Publication status	Published - Aug 1 2008

Bibliographical note

Funding Information:
This work was funded by the Multiple Sclerosis Society of Canada Scientific Research Foundation. S.V.R. is funded by the Medical Research Council of the United Kingdom. G.C.E. is the Action Research Professor of Clinical Neurology at the University of Oxford. The authors would like to thank all patients who generously participated in this study. The sponsor of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and final responsibility for the decision to submit for publication.

ASJC Scopus Subject Areas

Clinical Neurology

PubMed: MeSH publication types

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

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10.1186/1471-2377-8-30

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Ramagopalan, S. V., Valdar, W., Dyment, D. A., DeLuca, G. C., Orton, S. M., Yee, I. M., Criscuoli, M., Ebers, G. C., Dessa, A. D., Devonshire, V., Rieckmann, P., Hashimoto, S. A., Hooge, J., Kastrukoff, L., Oger, J. J. F., Smythe, J. P., Traboulsee, A., Smyth, P., Metz, L., ... Stefanelli, M. (2008). No effect of preterm birth on the risk of multiple sclerosis: A population based study. BMC Neurology, 8, Article 30. https://doi.org/10.1186/1471-2377-8-30

Ramagopalan, SV, Valdar, W, Dyment, DA, DeLuca, GC, Orton, SM, Yee, IM, Criscuoli, M, Ebers, GC, Dessa, AD, Devonshire, V, Rieckmann, P, Hashimoto, SA, Hooge, J, Kastrukoff, L, Oger, JJF, Smythe, JP, Traboulsee, A, Smyth, P, Metz, L, Warren, S, Hader, W, Knox, K, Rice, G, Kremenchutzky, M, Freedman, M, Brunet, D, O'Connor, P, Gray, T, Hohol, M, Duquette, P, Lapierre, Y, Murray, TJ, Bhan, V, Maxner, C & Stefanelli, M 2008, 'No effect of preterm birth on the risk of multiple sclerosis: A population based study', BMC Neurology, vol. 8, 30. https://doi.org/10.1186/1471-2377-8-30

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title = "No effect of preterm birth on the risk of multiple sclerosis: A population based study",

abstract = "Background: Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. A clear parent of origin effect has been shown in several populations, perhaps resulting from factors operating during gestation. Preterm birth (birth at less than 37 weeks gestational age) has been shown to result in long-term health problems, including impaired neurological development. Here, in a population-based cohort, we investigate whether preterm birth increases the risk to subsequently develop MS. Methods: We identified 6585 MS index cases and 2509 spousal controls with preterm birth information from the Canadian Collaborative Project on Genetic Susceptibility to MS. Rates of individuals born preterm were compared for index cases and controls. Results: There were no significant differences between cases and controls with respect to preterm births. 370 (5.6%) MS index cases and 130 (5.2%) spousal controls were born preterm, p = 0.41. Conclusion: Preterm birth does not appear to contribute to MS aetiology. Other factors involved in foetal and early development need to be explored to elucidate the mechanism of the increased risk conferred by the apparent maternal effect.",

author = "Ramagopalan, {Sreeram V.} and William Valdar and Dyment, {David A.} and DeLuca, {Gabriele C.} and Orton, {Sarah Michelle} and Yee, {Irene M.} and Maria Criscuoli and Ebers, {George C.} and Dessa, {A. Dessa} and V. Devonshire and P. Rieckmann and Hashimoto, {S. A.} and J. Hooge and L. Kastrukoff and Oger, {J. J.F.} and Smythe, {J. P.} and A. Traboulsee and P. Smyth and L. Metz and S. Warren and W. Hader and K. Knox and G. Rice and M. Kremenchutzky and M. Freedman and D. Brunet and P. O'Connor and T. Gray and M. Hohol and P. Duquette and Y. Lapierre and Murray, {T. J.} and V. Bhan and C. Maxner and M. Stefanelli",

note = "Funding Information: This work was funded by the Multiple Sclerosis Society of Canada Scientific Research Foundation. S.V.R. is funded by the Medical Research Council of the United Kingdom. G.C.E. is the Action Research Professor of Clinical Neurology at the University of Oxford. The authors would like to thank all patients who generously participated in this study. The sponsor of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and final responsibility for the decision to submit for publication.",

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doi = "10.1186/1471-2377-8-30",

language = "English",

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T1 - No effect of preterm birth on the risk of multiple sclerosis

T2 - A population based study

AU - Ramagopalan, Sreeram V.

AU - Valdar, William

AU - Dyment, David A.

AU - DeLuca, Gabriele C.

AU - Orton, Sarah Michelle

AU - Yee, Irene M.

AU - Criscuoli, Maria

AU - Ebers, George C.

AU - Dessa, A. Dessa

AU - Devonshire, V.

AU - Rieckmann, P.

AU - Hashimoto, S. A.

AU - Hooge, J.

AU - Kastrukoff, L.

AU - Oger, J. J.F.

AU - Smythe, J. P.

AU - Traboulsee, A.

AU - Smyth, P.

AU - Metz, L.

AU - Warren, S.

AU - Hader, W.

AU - Knox, K.

AU - Rice, G.

AU - Kremenchutzky, M.

AU - Freedman, M.

AU - Brunet, D.

AU - O'Connor, P.

AU - Gray, T.

AU - Hohol, M.

AU - Duquette, P.

AU - Lapierre, Y.

AU - Murray, T. J.

AU - Bhan, V.

AU - Maxner, C.

AU - Stefanelli, M.

N1 - Funding Information: This work was funded by the Multiple Sclerosis Society of Canada Scientific Research Foundation. S.V.R. is funded by the Medical Research Council of the United Kingdom. G.C.E. is the Action Research Professor of Clinical Neurology at the University of Oxford. The authors would like to thank all patients who generously participated in this study. The sponsor of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and final responsibility for the decision to submit for publication.

PY - 2008/8/1

Y1 - 2008/8/1

N2 - Background: Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. A clear parent of origin effect has been shown in several populations, perhaps resulting from factors operating during gestation. Preterm birth (birth at less than 37 weeks gestational age) has been shown to result in long-term health problems, including impaired neurological development. Here, in a population-based cohort, we investigate whether preterm birth increases the risk to subsequently develop MS. Methods: We identified 6585 MS index cases and 2509 spousal controls with preterm birth information from the Canadian Collaborative Project on Genetic Susceptibility to MS. Rates of individuals born preterm were compared for index cases and controls. Results: There were no significant differences between cases and controls with respect to preterm births. 370 (5.6%) MS index cases and 130 (5.2%) spousal controls were born preterm, p = 0.41. Conclusion: Preterm birth does not appear to contribute to MS aetiology. Other factors involved in foetal and early development need to be explored to elucidate the mechanism of the increased risk conferred by the apparent maternal effect.

AB - Background: Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. A clear parent of origin effect has been shown in several populations, perhaps resulting from factors operating during gestation. Preterm birth (birth at less than 37 weeks gestational age) has been shown to result in long-term health problems, including impaired neurological development. Here, in a population-based cohort, we investigate whether preterm birth increases the risk to subsequently develop MS. Methods: We identified 6585 MS index cases and 2509 spousal controls with preterm birth information from the Canadian Collaborative Project on Genetic Susceptibility to MS. Rates of individuals born preterm were compared for index cases and controls. Results: There were no significant differences between cases and controls with respect to preterm births. 370 (5.6%) MS index cases and 130 (5.2%) spousal controls were born preterm, p = 0.41. Conclusion: Preterm birth does not appear to contribute to MS aetiology. Other factors involved in foetal and early development need to be explored to elucidate the mechanism of the increased risk conferred by the apparent maternal effect.

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No effect of preterm birth on the risk of multiple sclerosis: A population based study

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Access to Document

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