Non-Canonical Host Intracellular Niche Links to New Antimicrobial Resistance Mechanism

Michaela Kember, Shannen Grandy, Renee Raudonis, Zhenyu Cheng

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

Globally, infectious diseases are one of the leading causes of death among people of all ages. The development of antimicrobials to treat infectious diseases has been one of the most significant advances in medical history. Alarmingly, antimicrobial resistance is a widespread phenomenon that will, without intervention, make currently treatable infections once again deadly. In an era of widespread antimicrobial resistance, there is a constant and pressing need to develop new anti-bacterial drugs. Unraveling the underlying resistance mechanisms is critical to fight this crisis. In this review, we summarize some emerging evidence of the non-canonical intracellular life cycle of two priority antimicrobial-resistant bacterial pathogens: Pseudomonas aeruginosa and Staphylococcus aureus. The bacterial factors that modulate this unique intracellular niche and its implications in contributing to resistance are discussed. We then briefly discuss some recent research that focused on the promises of boosting host immunity as a combination therapy with antimicrobials to eradicate these two particular pathogens. Finally, we summarize the importance of various strategies, including surveillance and vaccines, in mitigating the impacts of antimicrobial resistance in general.

Original languageEnglish
Article number220
JournalPathogens
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 2022

Bibliographical note

Funding Information:
This work was supported by a Nova Scotia Health Research Foundation Establishment Grant (2018-1536) and a Canadian Institutes of Health Research Project Grant (PJT165970) to Z.C.

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

ASJC Scopus Subject Areas

  • Immunology and Allergy
  • Molecular Biology
  • General Immunology and Microbiology
  • Microbiology (medical)
  • Infectious Diseases

PubMed: MeSH publication types

  • Journal Article
  • Review

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