Normative bone mineral density z-scores for canadians aged 16 to 24 years: The Canadian multicenter osteoporosis study

Wei Zhou; Lisa Langsetmo; Claudie Berger; Jonathan D. Adachi; Alexandra Papaioannou; George Ioannidis; Colin Webber; Stephanie A. Atkinson; Wojciech P. Olszynski; Jacques P. Brown; David A. Hanley; Robert Josse; Nancy Kreiger; Jerilynn Prior; Stephanie Kaiser; Susan Kirkland; David Goltzman; Kenneth Shawn Davison

doi:10.1016/j.jocd.2010.04.005

Normative bone mineral density z-scores for canadians aged 16 to 24 years: The Canadian multicenter osteoporosis study

Wei Zhou, Lisa Langsetmo, Claudie Berger, Jonathan D. Adachi, Alexandra Papaioannou, George Ioannidis, Colin Webber, Stephanie A. Atkinson, Wojciech P. Olszynski, Jacques P. Brown, David A. Hanley, Robert Josse, Nancy Kreiger, Jerilynn Prior, Stephanie Kaiser, Susan Kirkland, David Goltzman, Kenneth Shawn Davison

Medicine

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The objectives of the study were to develop bone mineral density (BMD) reference norms and BMD Z-scores at various skeletal sites, to determine whether prior fracture and/or asthma were related to BMD, and to assess possible geographic variation of BMD among Canadian youth aged 16-24. yr. Z-Scores were defined as the number of standard deviations from the mean BMD of a healthy population of the same age, race, and sex. Z-Scores were calculated using the reference sample defined as Canadian Caucasian participants without asthma or prior fracture. Reference standards were created for lumbar spine (L1-L4), femoral neck, total hip, and greater trochanter, by each year of age (16-24. yr), and by sex. The Z-score norms were developed for groups noted earlier. Mean Z-scores between the asthma or fracture subgroups compared with the mean Z-scores in the reference sample were not different. There were minor differences in mean BMD across different Canadian geographic regions. This study provides age, sex, and skeletal site-specific Caucasian reference norms and formulae for the calculation of BMD Z-scores for Canadian youth aged 16-24. yr. This information will be valuable to help to identify individuals with clinically meaningful low BMD.

Original language	English
Pages (from-to)	267-276
Number of pages	10
Journal	Journal of Clinical Densitometry
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/j.jocd.2010.04.005
Publication status	Published - Jul 2010

Bibliographical note

Funding Information:
The Canadian Multicenter Osteoporosis Study was funded by the Canadian Institutes of Health Research; Merck Frosst Canada Ltd.; Eli Lilly Canada Inc.; Novartis Pharmaceuticals Inc.; and The Alliance for Better Bone Health—sanofi-aventis and Procter & Gamble Pharmaceuticals Canada Inc.; Servier Canada Inc.; Amgen Canada Inc.; The Dairy Farmers of Canada; and The Arthritis Society. The authors thank all the participants in the Canadian Multicenter Osteoporosis Study. The authors would also like to thank Mrs. Louise Mailloux and Diane Bastien from the CaMos DXA Analysis Centre for reanalyzing the DXA.

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine
Radiology Nuclear Medicine and imaging

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jocd.2010.04.005

Cite this

Zhou, W., Langsetmo, L., Berger, C., Adachi, J. D., Papaioannou, A., Ioannidis, G., Webber, C., Atkinson, S. A., Olszynski, W. P., Brown, J. P., Hanley, D. A., Josse, R., Kreiger, N., Prior, J., Kaiser, S., Kirkland, S., Goltzman, D., & Davison, K. S. (2010). Normative bone mineral density z-scores for canadians aged 16 to 24 years: The Canadian multicenter osteoporosis study. Journal of Clinical Densitometry, 13(3), 267-276. https://doi.org/10.1016/j.jocd.2010.04.005

Zhou, W, Langsetmo, L, Berger, C, Adachi, JD, Papaioannou, A, Ioannidis, G, Webber, C, Atkinson, SA, Olszynski, WP, Brown, JP, Hanley, DA, Josse, R, Kreiger, N, Prior, J, Kaiser, S , Kirkland, S, Goltzman, D & Davison, KS 2010, 'Normative bone mineral density z-scores for canadians aged 16 to 24 years: The Canadian multicenter osteoporosis study', Journal of Clinical Densitometry, vol. 13, no. 3, pp. 267-276. https://doi.org/10.1016/j.jocd.2010.04.005

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abstract = "The objectives of the study were to develop bone mineral density (BMD) reference norms and BMD Z-scores at various skeletal sites, to determine whether prior fracture and/or asthma were related to BMD, and to assess possible geographic variation of BMD among Canadian youth aged 16-24. yr. Z-Scores were defined as the number of standard deviations from the mean BMD of a healthy population of the same age, race, and sex. Z-Scores were calculated using the reference sample defined as Canadian Caucasian participants without asthma or prior fracture. Reference standards were created for lumbar spine (L1-L4), femoral neck, total hip, and greater trochanter, by each year of age (16-24. yr), and by sex. The Z-score norms were developed for groups noted earlier. Mean Z-scores between the asthma or fracture subgroups compared with the mean Z-scores in the reference sample were not different. There were minor differences in mean BMD across different Canadian geographic regions. This study provides age, sex, and skeletal site-specific Caucasian reference norms and formulae for the calculation of BMD Z-scores for Canadian youth aged 16-24. yr. This information will be valuable to help to identify individuals with clinically meaningful low BMD.",

author = "Wei Zhou and Lisa Langsetmo and Claudie Berger and Adachi, {Jonathan D.} and Alexandra Papaioannou and George Ioannidis and Colin Webber and Atkinson, {Stephanie A.} and Olszynski, {Wojciech P.} and Brown, {Jacques P.} and Hanley, {David A.} and Robert Josse and Nancy Kreiger and Jerilynn Prior and Stephanie Kaiser and Susan Kirkland and David Goltzman and Davison, {Kenneth Shawn}",

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AU - Adachi, Jonathan D.

AU - Papaioannou, Alexandra

AU - Ioannidis, George

AU - Webber, Colin

AU - Atkinson, Stephanie A.

AU - Olszynski, Wojciech P.

AU - Brown, Jacques P.

AU - Hanley, David A.

AU - Josse, Robert

AU - Kreiger, Nancy

AU - Prior, Jerilynn

AU - Kaiser, Stephanie

AU - Kirkland, Susan

AU - Goltzman, David

AU - Davison, Kenneth Shawn

N1 - Funding Information: The Canadian Multicenter Osteoporosis Study was funded by the Canadian Institutes of Health Research; Merck Frosst Canada Ltd.; Eli Lilly Canada Inc.; Novartis Pharmaceuticals Inc.; and The Alliance for Better Bone Health—sanofi-aventis and Procter & Gamble Pharmaceuticals Canada Inc.; Servier Canada Inc.; Amgen Canada Inc.; The Dairy Farmers of Canada; and The Arthritis Society. The authors thank all the participants in the Canadian Multicenter Osteoporosis Study. The authors would also like to thank Mrs. Louise Mailloux and Diane Bastien from the CaMos DXA Analysis Centre for reanalyzing the DXA.

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N2 - The objectives of the study were to develop bone mineral density (BMD) reference norms and BMD Z-scores at various skeletal sites, to determine whether prior fracture and/or asthma were related to BMD, and to assess possible geographic variation of BMD among Canadian youth aged 16-24. yr. Z-Scores were defined as the number of standard deviations from the mean BMD of a healthy population of the same age, race, and sex. Z-Scores were calculated using the reference sample defined as Canadian Caucasian participants without asthma or prior fracture. Reference standards were created for lumbar spine (L1-L4), femoral neck, total hip, and greater trochanter, by each year of age (16-24. yr), and by sex. The Z-score norms were developed for groups noted earlier. Mean Z-scores between the asthma or fracture subgroups compared with the mean Z-scores in the reference sample were not different. There were minor differences in mean BMD across different Canadian geographic regions. This study provides age, sex, and skeletal site-specific Caucasian reference norms and formulae for the calculation of BMD Z-scores for Canadian youth aged 16-24. yr. This information will be valuable to help to identify individuals with clinically meaningful low BMD.

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Normative bone mineral density z-scores for canadians aged 16 to 24 years: The Canadian multicenter osteoporosis study

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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