One-year weight losses in the Tianjin Gestational Diabetes Mellitus Prevention Programme: A randomized clinical trial

Huikun Liu; Leishen Wang; Shuang Zhang; Junhong Leng; Nan Li; Weiqin Li; Jing Wang; Huiguang Tian; Lu Qi; Xilin Yang; Zhijie Yu; Jaakko Tuomilehto; Gang Hu

doi:10.1111/dom.13225

One-year weight losses in the Tianjin Gestational Diabetes Mellitus Prevention Programme: A randomized clinical trial

Huikun Liu, Leishen Wang, Shuang Zhang, Junhong Leng, Nan Li, Weiqin Li, Jing Wang, Huiguang Tian, Lu Qi, Xilin Yang, Zhijie Yu, Jaakko Tuomilehto, Gang Hu

Medicine

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Aims: To report the weight loss findings after the first year of a lifestyle intervention trial among women with gestational diabetes mellitus (GDM). Methods: A total of 1180 women with GDM were randomly assigned (1:1) to receive a 4-year lifestyle intervention (intervention group, n = 586) or standard care (control group, n = 594) between August 2009 and July 2011. Major elements of the intervention included 6 face-to-face sessions with study dieticians and two telephone calls in the first year, and two individual sessions and two telephone calls in each subsequent year. Results: Among 79% of participants who completed the year 1 trial, mean weight loss was 0.82 kg (1.12% of initial weight) in the intervention group and 0.09 kg (0.03% of initial weight) in the control group (P =.001). In a prespecified subgroup analysis of people who completed the trial, weight loss was more pronounced in women who were overweight (body mass index ≥24 kg/m²) at baseline: mean weight loss 2.01 kg (2.87% of initial weight) in the intervention group and 0.44 kg (0.52% of initial weight) in the control group (P <.001). Compared with those in the control group, women in the intervention group had a greater decrease in waist circumference (1.76 cm vs 0.73 cm; P =.003) and body fat (0.50% vs 0.05% increase; P =.001). Conclusion: The 1-year lifestyle intervention led to significant weight losses after delivery in women who had GDM, and the effect was more pronounced in women who were overweight at baseline.

Original language	English
Pages (from-to)	1246-1255
Number of pages	10
Journal	Diabetes, Obesity and Metabolism
Volume	20
Issue number	5
DOIs	https://doi.org/10.1111/dom.13225
Publication status	Published - May 2018

Bibliographical note

Funding Information:
This study is supported by a grant from the European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women's and Children's Health Centre, and Tianjin Public Health Bureau. Dr Hu was supported by the grant from the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100790) and the National Institute of General Medical Sciences (U54GM104940) of the National Institutes of Health. We thank all the families who participated in the Tianjin Gestational Diabetes Mellitus Prevention Programme. None declared. GH has full access to all of the data in this study. HL, HT, LQ, JT, XY, ZY, and GH were responsible for the study design and implementation. HL, LW, SZ, JL, NL, and WL collected and extracted data. WL, JW and GH did the statistical analysis. HL and GH wrote the first manuscript. All authors reviewed and approved the final manuscript.

Funding Information:
This study is supported by a grant from the European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women’s and Children’s Health Centre, and Tianjin Public Health Bureau. Dr Hu was supported by the grant from the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100790) and the National Institute of General Medical Sciences (U54GM104940) of the National Institutes of Health. We thank all the families who participated in the Tianjin Gestational Diabetes Mellitus Prevention Programme.

Publisher Copyright:
© 2018 John Wiley & Sons Ltd

ASJC Scopus Subject Areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

PubMed: MeSH publication types

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/dom.13225

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@article{36f6fa8e93dc4969876db8b032bf39c6,

title = "One-year weight losses in the Tianjin Gestational Diabetes Mellitus Prevention Programme: A randomized clinical trial",

abstract = "Aims: To report the weight loss findings after the first year of a lifestyle intervention trial among women with gestational diabetes mellitus (GDM). Methods: A total of 1180 women with GDM were randomly assigned (1:1) to receive a 4-year lifestyle intervention (intervention group, n = 586) or standard care (control group, n = 594) between August 2009 and July 2011. Major elements of the intervention included 6 face-to-face sessions with study dieticians and two telephone calls in the first year, and two individual sessions and two telephone calls in each subsequent year. Results: Among 79% of participants who completed the year 1 trial, mean weight loss was 0.82 kg (1.12% of initial weight) in the intervention group and 0.09 kg (0.03% of initial weight) in the control group (P =.001). In a prespecified subgroup analysis of people who completed the trial, weight loss was more pronounced in women who were overweight (body mass index ≥24 kg/m2) at baseline: mean weight loss 2.01 kg (2.87% of initial weight) in the intervention group and 0.44 kg (0.52% of initial weight) in the control group (P <.001). Compared with those in the control group, women in the intervention group had a greater decrease in waist circumference (1.76 cm vs 0.73 cm; P =.003) and body fat (0.50% vs 0.05% increase; P =.001). Conclusion: The 1-year lifestyle intervention led to significant weight losses after delivery in women who had GDM, and the effect was more pronounced in women who were overweight at baseline.",

author = "Huikun Liu and Leishen Wang and Shuang Zhang and Junhong Leng and Nan Li and Weiqin Li and Jing Wang and Huiguang Tian and Lu Qi and Xilin Yang and Zhijie Yu and Jaakko Tuomilehto and Gang Hu",

note = "Funding Information: This study is supported by a grant from the European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women's and Children's Health Centre, and Tianjin Public Health Bureau. Dr Hu was supported by the grant from the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100790) and the National Institute of General Medical Sciences (U54GM104940) of the National Institutes of Health. We thank all the families who participated in the Tianjin Gestational Diabetes Mellitus Prevention Programme. None declared. GH has full access to all of the data in this study. HL, HT, LQ, JT, XY, ZY, and GH were responsible for the study design and implementation. HL, LW, SZ, JL, NL, and WL collected and extracted data. WL, JW and GH did the statistical analysis. HL and GH wrote the first manuscript. All authors reviewed and approved the final manuscript. Funding Information: This study is supported by a grant from the European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women{\textquoteright}s and Children{\textquoteright}s Health Centre, and Tianjin Public Health Bureau. Dr Hu was supported by the grant from the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100790) and the National Institute of General Medical Sciences (U54GM104940) of the National Institutes of Health. We thank all the families who participated in the Tianjin Gestational Diabetes Mellitus Prevention Programme. Publisher Copyright: {\textcopyright} 2018 John Wiley & Sons Ltd",

year = "2018",

month = may,

doi = "10.1111/dom.13225",

language = "English",

volume = "20",

pages = "1246--1255",

journal = "Diabetes, Obesity and Metabolism",

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TY - JOUR

T1 - One-year weight losses in the Tianjin Gestational Diabetes Mellitus Prevention Programme

T2 - A randomized clinical trial

AU - Liu, Huikun

AU - Wang, Leishen

AU - Zhang, Shuang

AU - Leng, Junhong

AU - Li, Nan

AU - Li, Weiqin

AU - Wang, Jing

AU - Tian, Huiguang

AU - Qi, Lu

AU - Yang, Xilin

AU - Yu, Zhijie

AU - Tuomilehto, Jaakko

AU - Hu, Gang

N1 - Funding Information: This study is supported by a grant from the European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women's and Children's Health Centre, and Tianjin Public Health Bureau. Dr Hu was supported by the grant from the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100790) and the National Institute of General Medical Sciences (U54GM104940) of the National Institutes of Health. We thank all the families who participated in the Tianjin Gestational Diabetes Mellitus Prevention Programme. None declared. GH has full access to all of the data in this study. HL, HT, LQ, JT, XY, ZY, and GH were responsible for the study design and implementation. HL, LW, SZ, JL, NL, and WL collected and extracted data. WL, JW and GH did the statistical analysis. HL and GH wrote the first manuscript. All authors reviewed and approved the final manuscript. Funding Information: This study is supported by a grant from the European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women’s and Children’s Health Centre, and Tianjin Public Health Bureau. Dr Hu was supported by the grant from the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100790) and the National Institute of General Medical Sciences (U54GM104940) of the National Institutes of Health. We thank all the families who participated in the Tianjin Gestational Diabetes Mellitus Prevention Programme. Publisher Copyright: © 2018 John Wiley & Sons Ltd

PY - 2018/5

Y1 - 2018/5

N2 - Aims: To report the weight loss findings after the first year of a lifestyle intervention trial among women with gestational diabetes mellitus (GDM). Methods: A total of 1180 women with GDM were randomly assigned (1:1) to receive a 4-year lifestyle intervention (intervention group, n = 586) or standard care (control group, n = 594) between August 2009 and July 2011. Major elements of the intervention included 6 face-to-face sessions with study dieticians and two telephone calls in the first year, and two individual sessions and two telephone calls in each subsequent year. Results: Among 79% of participants who completed the year 1 trial, mean weight loss was 0.82 kg (1.12% of initial weight) in the intervention group and 0.09 kg (0.03% of initial weight) in the control group (P =.001). In a prespecified subgroup analysis of people who completed the trial, weight loss was more pronounced in women who were overweight (body mass index ≥24 kg/m2) at baseline: mean weight loss 2.01 kg (2.87% of initial weight) in the intervention group and 0.44 kg (0.52% of initial weight) in the control group (P <.001). Compared with those in the control group, women in the intervention group had a greater decrease in waist circumference (1.76 cm vs 0.73 cm; P =.003) and body fat (0.50% vs 0.05% increase; P =.001). Conclusion: The 1-year lifestyle intervention led to significant weight losses after delivery in women who had GDM, and the effect was more pronounced in women who were overweight at baseline.

AB - Aims: To report the weight loss findings after the first year of a lifestyle intervention trial among women with gestational diabetes mellitus (GDM). Methods: A total of 1180 women with GDM were randomly assigned (1:1) to receive a 4-year lifestyle intervention (intervention group, n = 586) or standard care (control group, n = 594) between August 2009 and July 2011. Major elements of the intervention included 6 face-to-face sessions with study dieticians and two telephone calls in the first year, and two individual sessions and two telephone calls in each subsequent year. Results: Among 79% of participants who completed the year 1 trial, mean weight loss was 0.82 kg (1.12% of initial weight) in the intervention group and 0.09 kg (0.03% of initial weight) in the control group (P =.001). In a prespecified subgroup analysis of people who completed the trial, weight loss was more pronounced in women who were overweight (body mass index ≥24 kg/m2) at baseline: mean weight loss 2.01 kg (2.87% of initial weight) in the intervention group and 0.44 kg (0.52% of initial weight) in the control group (P <.001). Compared with those in the control group, women in the intervention group had a greater decrease in waist circumference (1.76 cm vs 0.73 cm; P =.003) and body fat (0.50% vs 0.05% increase; P =.001). Conclusion: The 1-year lifestyle intervention led to significant weight losses after delivery in women who had GDM, and the effect was more pronounced in women who were overweight at baseline.

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One-year weight losses in the Tianjin Gestational Diabetes Mellitus Prevention Programme: A randomized clinical trial

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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