Operationalization of the updated diagnostic algorithm for classifying HIV-related cognitive impairment and dementia

J. M. Foley, M. J. Wright, A. L. Gooding, M. Ettenhofer, M. Kim, M. Choi, S. A. Castellon, J. Sadek, R. K. Heaton, W. G. Van Gorp, T. D. Marcotte, C. H. Hinkin

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Background: This study applies the updated HIV-Associated Neurocognitive Disorders (HAND) diagnostic algorithm. Methods: Participants were 210 HIV-infected-adults, classified using proposed HAND criteria: HIV-Associated Dementia (HAD), Mild Neurocognitive Disorder (MND), Asymptomatic Neurocognitive Impairment (ANI). Results: The algorithm yielded: normal = 32.8%, ANI = 21.4%, MND = 34.3%, and HAD = 11.4%. Normal participants performed superior to HAND-defined participants on cognition, and HAD participants performed more poorly on global cognition and executive functioning. Two distinct subgroups of interest emerged: (1) functional decline without cognitive impairment; (2) severe cognitive impairment and minimal functional compromise. Conclusions: The algorithm discriminates between HIV-infected cognitively impaired individuals. Diagnosis yields two unique profiles requiring further investigation. Findings largely support the algorithm's utility for diagnosing HIV-cognitive-impairment, but suggest distinct subsets of individuals with discrepant cognitive/functional performances that may not be readily apparent by conventional application of HAND diagnosis.

Original languageEnglish
Pages (from-to)835-843
Number of pages9
JournalInternational Psychogeriatrics
Volume23
Issue number5
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

ASJC Scopus Subject Areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

Fingerprint

Dive into the research topics of 'Operationalization of the updated diagnostic algorithm for classifying HIV-related cognitive impairment and dementia'. Together they form a unique fingerprint.

Cite this