Optical Coherence Tomography Optic Nerve Head Morphology in Myopia I: Implications of Anterior Scleral Canal Opening Versus Bruch Membrane Opening Offset

Jin Wook Jeoung; Hongli Yang; Stuart Gardiner; Ya Xing Wang; Seungwoo Hong; Brad Fortune; Michaël J.A. Girard; Christy Hardin; Ping Wei; Marcelo Nicolela; Jayme R. Vianna; Balwantray C. Chauhan; Claude F. Burgoyne

doi:10.1016/j.ajo.2020.05.015

Optical Coherence Tomography Optic Nerve Head Morphology in Myopia I: Implications of Anterior Scleral Canal Opening Versus Bruch Membrane Opening Offset

Jin Wook Jeoung, Hongli Yang, Stuart Gardiner, Ya Xing Wang, Seungwoo Hong, Brad Fortune, Michaël J.A. Girard, Christy Hardin, Ping Wei, Marcelo Nicolela, Jayme R. Vianna, Balwantray C. Chauhan, Claude F. Burgoyne

Medicine

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Purpose: To measure the magnitude and direction of anterior scleral canal opening (ASCO) offset relative to the Bruch membrane opening (BMO) (ASCO/BMO offset) to characterize neural canal obliqueness and minimum cross-sectional area (NCMCA) in 69 highly myopic and 138 healthy, age-matched, control eyes. Design: Cross-sectional study. Methods: Using optical coherence tomography (OCT) scans of the optic nerve head (ONH), BMO and ASCO were manually segmented and their centroids and size and shape were calculated. ASCO/BMO offset magnitude and direction were measured after projecting the ASCO/BMO centroid vector onto the BMO plane. Neural canal axis obliqueness was defined as the angle between the ASCO/BMO centroid vector and the vector perpendicular to the BMO plane. NCMCA was defined by projecting BMO and ASCO points onto a plane perpendicular to the neural canal axis and measuring their overlapping area. Results: ASCO/BMO offset magnitude was greater (highly myopic eyes 264.3 ± 131.1 μm; healthy control subjects 89.0 ± 55.8 μm, P <.001, t test) and ASCO centroid was most frequently nasal relative to BMO centroid (94.2% of eyes) in the highly myopic eyes. BMO and ASCO areas were significantly larger (P <.001, t test), NCMCA was significantly smaller (P <.001), and all 3 were significantly more elliptical (P ≤.001) in myopic eyes. Neural canal obliqueness was greater in myopic (65.17° ± 14.03°) compared with control eyes (40.91° ± 16.22°; P <.001, t test). Conclusions: Our data suggest that increased temporal displacement of BMO relative to the ASCO, increased BMO and ASCO area, decreased NCMCA, and increased neural canal obliqueness are characteristic components of ONH morphology in highly myopic eyes.

Original language	English
Pages (from-to)	105-119
Number of pages	15
Journal	American Journal of Ophthalmology
Volume	218
DOIs	https://doi.org/10.1016/j.ajo.2020.05.015
Publication status	Published - Oct 2020

Bibliographical note

Funding Information:
Funding/Support: Supported by a National Eye Institute Grant (NIH/NEI R01-EY021281), a grant from the Canadian National Institute for the Blind–Canadian Glaucoma Clinical Research Council; with supplemental support from a Mathers Fellowship award; Legacy Good Samaritan Foundation; and Heidelberg Engineering, GmbH, Heidelberg, Germany.

Funding Information:
Funding/Support: Supported by a National Eye Institute Grant (NIH/NEI R01-EY021281), a grant from the Canadian National Institute for the Blind?Canadian Glaucoma Clinical Research Council; with supplemental support from a Mathers Fellowship award; Legacy Good Samaritan Foundation; and Heidelberg Engineering, GmbH, Heidelberg, Germany. JW. Jeoung: None. H. Yang: None. S. Gardiner: Nonfinancial support?Heidelberg Engineering. YX. Wang: None. SW. Hong: None. B. Fortune: Financial support - Legacy Good Samaritan Foundation, Inotek Pharmaceuticals. M. Girard: Financial support - Abyss Processing Pte Ltd. C. Hardin: None. P. Wei: None. M. Nicolela: None. J. R. Vianna: None. B. C. Chauhan: Financial support - Heidelberg Engineering. C. F. Burgoyne: Financial support - NIH/NEI R01-EY021281, Legacy Good Samaritan Foundation, Heidelberg Engineering. The above listed sponsors/funding organizations had no role in the design, conduct, analysis or reporting of this research. Other Acknowledgments: All authors have completed and submitted the ICMJE form for disclosure of potential conflicts of interest. Financial Disclosures: All authors attest that they meet the current ICMJE criteria for authorship.

Publisher Copyright:
© 2020 Elsevier Inc.

ASJC Scopus Subject Areas

Ophthalmology

PubMed: MeSH publication types

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Access to Document

10.1016/j.ajo.2020.05.015

Cite this

Jeoung, J. W., Yang, H., Gardiner, S., Wang, Y. X., Hong, S., Fortune, B., Girard, M. J. A., Hardin, C., Wei, P., Nicolela, M., Vianna, J. R., Chauhan, B. C., & Burgoyne, C. F. (2020). Optical Coherence Tomography Optic Nerve Head Morphology in Myopia I: Implications of Anterior Scleral Canal Opening Versus Bruch Membrane Opening Offset. American Journal of Ophthalmology, 218, 105-119. https://doi.org/10.1016/j.ajo.2020.05.015

Jeoung, JW, Yang, H, Gardiner, S, Wang, YX, Hong, S, Fortune, B, Girard, MJA, Hardin, C, Wei, P, Nicolela, M, Vianna, JR, Chauhan, BC & Burgoyne, CF 2020, 'Optical Coherence Tomography Optic Nerve Head Morphology in Myopia I: Implications of Anterior Scleral Canal Opening Versus Bruch Membrane Opening Offset', American Journal of Ophthalmology, vol. 218, pp. 105-119. https://doi.org/10.1016/j.ajo.2020.05.015

@article{9b3df38bd96d4405bf657264444bb2bd,

title = "Optical Coherence Tomography Optic Nerve Head Morphology in Myopia I: Implications of Anterior Scleral Canal Opening Versus Bruch Membrane Opening Offset",

abstract = "Purpose: To measure the magnitude and direction of anterior scleral canal opening (ASCO) offset relative to the Bruch membrane opening (BMO) (ASCO/BMO offset) to characterize neural canal obliqueness and minimum cross-sectional area (NCMCA) in 69 highly myopic and 138 healthy, age-matched, control eyes. Design: Cross-sectional study. Methods: Using optical coherence tomography (OCT) scans of the optic nerve head (ONH), BMO and ASCO were manually segmented and their centroids and size and shape were calculated. ASCO/BMO offset magnitude and direction were measured after projecting the ASCO/BMO centroid vector onto the BMO plane. Neural canal axis obliqueness was defined as the angle between the ASCO/BMO centroid vector and the vector perpendicular to the BMO plane. NCMCA was defined by projecting BMO and ASCO points onto a plane perpendicular to the neural canal axis and measuring their overlapping area. Results: ASCO/BMO offset magnitude was greater (highly myopic eyes 264.3 ± 131.1 μm; healthy control subjects 89.0 ± 55.8 μm, P <.001, t test) and ASCO centroid was most frequently nasal relative to BMO centroid (94.2% of eyes) in the highly myopic eyes. BMO and ASCO areas were significantly larger (P <.001, t test), NCMCA was significantly smaller (P <.001), and all 3 were significantly more elliptical (P ≤.001) in myopic eyes. Neural canal obliqueness was greater in myopic (65.17° ± 14.03°) compared with control eyes (40.91° ± 16.22°; P <.001, t test). Conclusions: Our data suggest that increased temporal displacement of BMO relative to the ASCO, increased BMO and ASCO area, decreased NCMCA, and increased neural canal obliqueness are characteristic components of ONH morphology in highly myopic eyes.",

author = "Jeoung, {Jin Wook} and Hongli Yang and Stuart Gardiner and Wang, {Ya Xing} and Seungwoo Hong and Brad Fortune and Girard, {Micha{\"e}l J.A.} and Christy Hardin and Ping Wei and Marcelo Nicolela and Vianna, {Jayme R.} and Chauhan, {Balwantray C.} and Burgoyne, {Claude F.}",

note = "Funding Information: Funding/Support: Supported by a National Eye Institute Grant (NIH/NEI R01-EY021281), a grant from the Canadian National Institute for the Blind–Canadian Glaucoma Clinical Research Council; with supplemental support from a Mathers Fellowship award; Legacy Good Samaritan Foundation; and Heidelberg Engineering, GmbH, Heidelberg, Germany. Funding Information: Funding/Support: Supported by a National Eye Institute Grant (NIH/NEI R01-EY021281), a grant from the Canadian National Institute for the Blind?Canadian Glaucoma Clinical Research Council; with supplemental support from a Mathers Fellowship award; Legacy Good Samaritan Foundation; and Heidelberg Engineering, GmbH, Heidelberg, Germany. JW. Jeoung: None. H. Yang: None. S. Gardiner: Nonfinancial support?Heidelberg Engineering. YX. Wang: None. SW. Hong: None. B. Fortune: Financial support - Legacy Good Samaritan Foundation, Inotek Pharmaceuticals. M. Girard: Financial support - Abyss Processing Pte Ltd. C. Hardin: None. P. Wei: None. M. Nicolela: None. J. R. Vianna: None. B. C. Chauhan: Financial support - Heidelberg Engineering. C. F. Burgoyne: Financial support - NIH/NEI R01-EY021281, Legacy Good Samaritan Foundation, Heidelberg Engineering. The above listed sponsors/funding organizations had no role in the design, conduct, analysis or reporting of this research. Other Acknowledgments: All authors have completed and submitted the ICMJE form for disclosure of potential conflicts of interest. Financial Disclosures: All authors attest that they meet the current ICMJE criteria for authorship. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = oct,

doi = "10.1016/j.ajo.2020.05.015",

language = "English",

volume = "218",

pages = "105--119",

journal = "American Journal of Ophthalmology",

issn = "0002-9394",

publisher = "Elsevier USA",

}

TY - JOUR

T1 - Optical Coherence Tomography Optic Nerve Head Morphology in Myopia I

T2 - Implications of Anterior Scleral Canal Opening Versus Bruch Membrane Opening Offset

AU - Jeoung, Jin Wook

AU - Yang, Hongli

AU - Gardiner, Stuart

AU - Wang, Ya Xing

AU - Hong, Seungwoo

AU - Fortune, Brad

AU - Girard, Michaël J.A.

AU - Hardin, Christy

AU - Wei, Ping

AU - Nicolela, Marcelo

AU - Vianna, Jayme R.

AU - Chauhan, Balwantray C.

AU - Burgoyne, Claude F.

N1 - Funding Information: Funding/Support: Supported by a National Eye Institute Grant (NIH/NEI R01-EY021281), a grant from the Canadian National Institute for the Blind–Canadian Glaucoma Clinical Research Council; with supplemental support from a Mathers Fellowship award; Legacy Good Samaritan Foundation; and Heidelberg Engineering, GmbH, Heidelberg, Germany. Funding Information: Funding/Support: Supported by a National Eye Institute Grant (NIH/NEI R01-EY021281), a grant from the Canadian National Institute for the Blind?Canadian Glaucoma Clinical Research Council; with supplemental support from a Mathers Fellowship award; Legacy Good Samaritan Foundation; and Heidelberg Engineering, GmbH, Heidelberg, Germany. JW. Jeoung: None. H. Yang: None. S. Gardiner: Nonfinancial support?Heidelberg Engineering. YX. Wang: None. SW. Hong: None. B. Fortune: Financial support - Legacy Good Samaritan Foundation, Inotek Pharmaceuticals. M. Girard: Financial support - Abyss Processing Pte Ltd. C. Hardin: None. P. Wei: None. M. Nicolela: None. J. R. Vianna: None. B. C. Chauhan: Financial support - Heidelberg Engineering. C. F. Burgoyne: Financial support - NIH/NEI R01-EY021281, Legacy Good Samaritan Foundation, Heidelberg Engineering. The above listed sponsors/funding organizations had no role in the design, conduct, analysis or reporting of this research. Other Acknowledgments: All authors have completed and submitted the ICMJE form for disclosure of potential conflicts of interest. Financial Disclosures: All authors attest that they meet the current ICMJE criteria for authorship. Publisher Copyright: © 2020 Elsevier Inc.

PY - 2020/10

Y1 - 2020/10

N2 - Purpose: To measure the magnitude and direction of anterior scleral canal opening (ASCO) offset relative to the Bruch membrane opening (BMO) (ASCO/BMO offset) to characterize neural canal obliqueness and minimum cross-sectional area (NCMCA) in 69 highly myopic and 138 healthy, age-matched, control eyes. Design: Cross-sectional study. Methods: Using optical coherence tomography (OCT) scans of the optic nerve head (ONH), BMO and ASCO were manually segmented and their centroids and size and shape were calculated. ASCO/BMO offset magnitude and direction were measured after projecting the ASCO/BMO centroid vector onto the BMO plane. Neural canal axis obliqueness was defined as the angle between the ASCO/BMO centroid vector and the vector perpendicular to the BMO plane. NCMCA was defined by projecting BMO and ASCO points onto a plane perpendicular to the neural canal axis and measuring their overlapping area. Results: ASCO/BMO offset magnitude was greater (highly myopic eyes 264.3 ± 131.1 μm; healthy control subjects 89.0 ± 55.8 μm, P <.001, t test) and ASCO centroid was most frequently nasal relative to BMO centroid (94.2% of eyes) in the highly myopic eyes. BMO and ASCO areas were significantly larger (P <.001, t test), NCMCA was significantly smaller (P <.001), and all 3 were significantly more elliptical (P ≤.001) in myopic eyes. Neural canal obliqueness was greater in myopic (65.17° ± 14.03°) compared with control eyes (40.91° ± 16.22°; P <.001, t test). Conclusions: Our data suggest that increased temporal displacement of BMO relative to the ASCO, increased BMO and ASCO area, decreased NCMCA, and increased neural canal obliqueness are characteristic components of ONH morphology in highly myopic eyes.

AB - Purpose: To measure the magnitude and direction of anterior scleral canal opening (ASCO) offset relative to the Bruch membrane opening (BMO) (ASCO/BMO offset) to characterize neural canal obliqueness and minimum cross-sectional area (NCMCA) in 69 highly myopic and 138 healthy, age-matched, control eyes. Design: Cross-sectional study. Methods: Using optical coherence tomography (OCT) scans of the optic nerve head (ONH), BMO and ASCO were manually segmented and their centroids and size and shape were calculated. ASCO/BMO offset magnitude and direction were measured after projecting the ASCO/BMO centroid vector onto the BMO plane. Neural canal axis obliqueness was defined as the angle between the ASCO/BMO centroid vector and the vector perpendicular to the BMO plane. NCMCA was defined by projecting BMO and ASCO points onto a plane perpendicular to the neural canal axis and measuring their overlapping area. Results: ASCO/BMO offset magnitude was greater (highly myopic eyes 264.3 ± 131.1 μm; healthy control subjects 89.0 ± 55.8 μm, P <.001, t test) and ASCO centroid was most frequently nasal relative to BMO centroid (94.2% of eyes) in the highly myopic eyes. BMO and ASCO areas were significantly larger (P <.001, t test), NCMCA was significantly smaller (P <.001), and all 3 were significantly more elliptical (P ≤.001) in myopic eyes. Neural canal obliqueness was greater in myopic (65.17° ± 14.03°) compared with control eyes (40.91° ± 16.22°; P <.001, t test). Conclusions: Our data suggest that increased temporal displacement of BMO relative to the ASCO, increased BMO and ASCO area, decreased NCMCA, and increased neural canal obliqueness are characteristic components of ONH morphology in highly myopic eyes.

UR - http://www.scopus.com/inward/record.url?scp=85088787196&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85088787196&partnerID=8YFLogxK

U2 - 10.1016/j.ajo.2020.05.015

DO - 10.1016/j.ajo.2020.05.015

M3 - Article

C2 - 32445702

AN - SCOPUS:85088787196

SN - 0002-9394

VL - 218

SP - 105

EP - 119

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

ER -

Optical Coherence Tomography Optic Nerve Head Morphology in Myopia I: Implications of Anterior Scleral Canal Opening Versus Bruch Membrane Opening Offset

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Access to Document

Other files and links

Fingerprint

Cite this