Organisation of the murine 5-HT3 receptor gene and assignment tohuman chromosome 11

Peter Uetz; Fawzy Abdelatty; Alfredo Villarroel; Gudrun Rappold; Birgit Weiss; Michael Koenen

doi:10.1016/0014-5793(94)80435-4

Organisation of the murine 5-HT₃ receptor gene and assignment tohuman chromosome 11

Peter Uetz, Fawzy Abdelatty, Alfredo Villarroel, Gudrun Rappold, Birgit Weiss, Michael Koenen

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

We have isolated the murine gene encoding the 5-HT₃ receptor (5-HT₃R), a member of the ligand-gated ion channels, that mediates a variety of physiological effects in central and peripheral neurons. DNA sequence analysis of the 5-HT₃R gene revealed its organisation in 9 exons distributed over approximately 12 kbp of DNA. Alternative use ofexon 9 splice acceptor sites generated two 5-HT₃R variants. The 5-HT₃R gene, whose structure is closely related to neuronal and muscle AChRα genes, as demonstrated by four common splice junctions, was localised on human chromosome 11.

Original language	English
Pages (from-to)	302-306
Number of pages	5
Journal	FEBS Letters
Volume	339
Issue number	3
DOIs	https://doi.org/10.1016/0014-5793(94)80435-4
Publication status	Published - Feb 21 1994
Externally published	Yes

ASJC Scopus Subject Areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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AU - Rappold, Gudrun

AU - Weiss, Birgit

AU - Koenen, Michael

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Y1 - 1994/2/21

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AB - We have isolated the murine gene encoding the 5-HT3 receptor (5-HT3R), a member of the ligand-gated ion channels, that mediates a variety of physiological effects in central and peripheral neurons. DNA sequence analysis of the 5-HT3R gene revealed its organisation in 9 exons distributed over approximately 12 kbp of DNA. Alternative use ofexon 9 splice acceptor sites generated two 5-HT3R variants. The 5-HT3R gene, whose structure is closely related to neuronal and muscle AChRα genes, as demonstrated by four common splice junctions, was localised on human chromosome 11.

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Organisation of the murine 5-HT₃ receptor gene and assignment tohuman chromosome 11

Abstract

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