Ouabain selectively affects the slow component of sensory adaptation in an insect mechanoreceptor

Andrew S. French

doi:10.1016/0006-8993(89)91604-1

Ouabain selectively affects the slow component of sensory adaptation in an insect mechanoreceptor

Andrew S. French

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Sensory activity in the cockroach tactile spine neuron adapts rapidly to a step deflection. This rapid adaptation is caused by a rise in the threshold for action potential production, which has two components with different time constants and drug sensitivities. The basis of the slow component is unknown but it is insensitive to a wide range of ion channel blockers. In the present experiments the slow component was selectively reduced by ouabain, suggesting that it is due to the activation of an electrogenic sodium pump.

Original language	English
Pages (from-to)	112-114
Number of pages	3
Journal	Brain Research
Volume	504
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(89)91604-1
Publication status	Published - Dec 11 1989
Externally published	Yes

Bibliographical note

Funding Information:
Rodney Gramlich provided expert technical assistance throughout this work, which was supported by the Canadian Medical Research Council and the Alberta Heritage Foundation for Medical Research.

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(89)91604-1

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N2 - Sensory activity in the cockroach tactile spine neuron adapts rapidly to a step deflection. This rapid adaptation is caused by a rise in the threshold for action potential production, which has two components with different time constants and drug sensitivities. The basis of the slow component is unknown but it is insensitive to a wide range of ion channel blockers. In the present experiments the slow component was selectively reduced by ouabain, suggesting that it is due to the activation of an electrogenic sodium pump.

AB - Sensory activity in the cockroach tactile spine neuron adapts rapidly to a step deflection. This rapid adaptation is caused by a rise in the threshold for action potential production, which has two components with different time constants and drug sensitivities. The basis of the slow component is unknown but it is insensitive to a wide range of ion channel blockers. In the present experiments the slow component was selectively reduced by ouabain, suggesting that it is due to the activation of an electrogenic sodium pump.

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Ouabain selectively affects the slow component of sensory adaptation in an insect mechanoreceptor

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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