TY - JOUR
T1 - Patient perceptions of islet transplantation for type 1 diabetes
AU - Fung, Michelle A.
AU - Barts, Agnieszka
AU - Thompson, David M.
AU - Ransom, Thomas P.P.
AU - Elliott, Tom G.
AU - Sirrs, Sandra M.
AU - Ur, Ehud
PY - 2010/9
Y1 - 2010/9
N2 - Objective: To determine the demand for islet transplantation among patients with type 1 diabetes. Methods: Surveys were mailed to patients with type 1 diabetes at 2 centres: 1 with an islet transplantation program (Vancouver, British Columbia) and another without a program (Halifax, Nova Scotia). The primary outcome was patient acceptance of islet transplantation after learning about the risks and benefits. Results: Of the 588 responses from a sample of 1499, 451 (76.7%) would accept or probably accept islet transplantation. Most common reasons for acceptance were 1) fewer diabetes-related complications (92.7%); 2) decreased hypoglycemia (78.5%); and 3) no insulin injections (75.0%). The rest, 137 (23.3%) respondents, would not or probably not accept islet transplantation because of 1) immunosuppressant medications (90.6%); 2) risks not yet identified (58.8%). Most would not consider islet transplantation a failure if insulin was required post-transplant (71%). Acceptance was higher among those who were younger and had less formal education and a lower household income. Patients who would accept islet transplantation had higher glycated hemoglobin, used higher doses of insulin and had worse perceived diabetes control and general health. Conclusions: The majority of patients with type 1 diabetes surveyed for this study would accept islet transplantation, with expectations of fewer complications, decreased hypoglycemia and freedom from insulin.
AB - Objective: To determine the demand for islet transplantation among patients with type 1 diabetes. Methods: Surveys were mailed to patients with type 1 diabetes at 2 centres: 1 with an islet transplantation program (Vancouver, British Columbia) and another without a program (Halifax, Nova Scotia). The primary outcome was patient acceptance of islet transplantation after learning about the risks and benefits. Results: Of the 588 responses from a sample of 1499, 451 (76.7%) would accept or probably accept islet transplantation. Most common reasons for acceptance were 1) fewer diabetes-related complications (92.7%); 2) decreased hypoglycemia (78.5%); and 3) no insulin injections (75.0%). The rest, 137 (23.3%) respondents, would not or probably not accept islet transplantation because of 1) immunosuppressant medications (90.6%); 2) risks not yet identified (58.8%). Most would not consider islet transplantation a failure if insulin was required post-transplant (71%). Acceptance was higher among those who were younger and had less formal education and a lower household income. Patients who would accept islet transplantation had higher glycated hemoglobin, used higher doses of insulin and had worse perceived diabetes control and general health. Conclusions: The majority of patients with type 1 diabetes surveyed for this study would accept islet transplantation, with expectations of fewer complications, decreased hypoglycemia and freedom from insulin.
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U2 - 10.1016/S1499-2671(10)43008-7
DO - 10.1016/S1499-2671(10)43008-7
M3 - Article
AN - SCOPUS:78650835057
SN - 1499-2671
VL - 34
SP - 203
EP - 210
JO - Canadian Journal of Diabetes
JF - Canadian Journal of Diabetes
IS - 3
ER -