Peripheral phosphodiesterase 4 inhibition produced by 4-[2-(3,4-bis- difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl) -phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) prevents experimental autoimmune encephalomyelitis

C. S. Moore, N. Earl, R. Frenette, A. Styhler, J. A. Mancini, D. W. Nicholson, A. L.O. Hebb, T. Owens, G. S. Robertson

Medicine

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