Phase-shifting effects of pituitary adenylate cyclase activating polypeptide on hamster wheel-running rhythms

Hugh D. Piggins; Elliott G. Marchant; Donna Goguen; Benjamin Rusak

doi:10.1016/S0304-3940(01)01796-7

Phase-shifting effects of pituitary adenylate cyclase activating polypeptide on hamster wheel-running rhythms

Hugh D. Piggins, Elliott G. Marchant, Donna Goguen, Benjamin Rusak

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP38) is a putative neurochemical of the main retinal input to the mammalian circadian pacemaker housed in the suprachiasmatic nucleus (SCN). We assessed the phase-resetting effects of microinjection of PACAP38 into the SCN region on hamster wheel-running rhythms. When administered during the middle of the subjective day, PACAP38 evoked large but transient phase advances (∼60 min), that were followed by small, steady-state phase delays. During the early subjective night, PACAP38 elicited small to moderate phase delays without any detectable concentration-dependence. Late in the subjective night, PACAP38 had no significant effects. Saline microinjection had no effect at any phase tested. These findings show that PACAP38 has small to moderate effects on the phase of the hamster SCN circadian pacemaker, including significant phase delays early in the subjective night.

Original language	English
Pages (from-to)	25-28
Number of pages	4
Journal	Neuroscience Letters
Volume	305
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(01)01796-7
Publication status	Published - Jun 1 2001

Bibliographical note

Funding Information:
We thank Debbie Fice and Marc Goguen for their excellent technical assistance. This research was supported by a postdoctoral fellowship from NSERC to E.G.M. and by grants to B.R. from NSERC (A0305) and CIHR (MOP-8929). H.D.P. was supported by MRC (UK).

ASJC Scopus Subject Areas

General Neuroscience

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

Access to Document

10.1016/S0304-3940(01)01796-7

Cite this

@article{067ad64741384119ae734241d5a56458,

title = "Phase-shifting effects of pituitary adenylate cyclase activating polypeptide on hamster wheel-running rhythms",

abstract = "Pituitary adenylate cyclase activating polypeptide (PACAP38) is a putative neurochemical of the main retinal input to the mammalian circadian pacemaker housed in the suprachiasmatic nucleus (SCN). We assessed the phase-resetting effects of microinjection of PACAP38 into the SCN region on hamster wheel-running rhythms. When administered during the middle of the subjective day, PACAP38 evoked large but transient phase advances (∼60 min), that were followed by small, steady-state phase delays. During the early subjective night, PACAP38 elicited small to moderate phase delays without any detectable concentration-dependence. Late in the subjective night, PACAP38 had no significant effects. Saline microinjection had no effect at any phase tested. These findings show that PACAP38 has small to moderate effects on the phase of the hamster SCN circadian pacemaker, including significant phase delays early in the subjective night.",

author = "Piggins, {Hugh D.} and Marchant, {Elliott G.} and Donna Goguen and Benjamin Rusak",

note = "Funding Information: We thank Debbie Fice and Marc Goguen for their excellent technical assistance. This research was supported by a postdoctoral fellowship from NSERC to E.G.M. and by grants to B.R. from NSERC (A0305) and CIHR (MOP-8929). H.D.P. was supported by MRC (UK). ",

year = "2001",

month = jun,

day = "1",

doi = "10.1016/S0304-3940(01)01796-7",

language = "English",

volume = "305",

pages = "25--28",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Phase-shifting effects of pituitary adenylate cyclase activating polypeptide on hamster wheel-running rhythms

AU - Piggins, Hugh D.

AU - Marchant, Elliott G.

AU - Goguen, Donna

AU - Rusak, Benjamin

N1 - Funding Information: We thank Debbie Fice and Marc Goguen for their excellent technical assistance. This research was supported by a postdoctoral fellowship from NSERC to E.G.M. and by grants to B.R. from NSERC (A0305) and CIHR (MOP-8929). H.D.P. was supported by MRC (UK).

PY - 2001/6/1

Y1 - 2001/6/1

N2 - Pituitary adenylate cyclase activating polypeptide (PACAP38) is a putative neurochemical of the main retinal input to the mammalian circadian pacemaker housed in the suprachiasmatic nucleus (SCN). We assessed the phase-resetting effects of microinjection of PACAP38 into the SCN region on hamster wheel-running rhythms. When administered during the middle of the subjective day, PACAP38 evoked large but transient phase advances (∼60 min), that were followed by small, steady-state phase delays. During the early subjective night, PACAP38 elicited small to moderate phase delays without any detectable concentration-dependence. Late in the subjective night, PACAP38 had no significant effects. Saline microinjection had no effect at any phase tested. These findings show that PACAP38 has small to moderate effects on the phase of the hamster SCN circadian pacemaker, including significant phase delays early in the subjective night.

AB - Pituitary adenylate cyclase activating polypeptide (PACAP38) is a putative neurochemical of the main retinal input to the mammalian circadian pacemaker housed in the suprachiasmatic nucleus (SCN). We assessed the phase-resetting effects of microinjection of PACAP38 into the SCN region on hamster wheel-running rhythms. When administered during the middle of the subjective day, PACAP38 evoked large but transient phase advances (∼60 min), that were followed by small, steady-state phase delays. During the early subjective night, PACAP38 elicited small to moderate phase delays without any detectable concentration-dependence. Late in the subjective night, PACAP38 had no significant effects. Saline microinjection had no effect at any phase tested. These findings show that PACAP38 has small to moderate effects on the phase of the hamster SCN circadian pacemaker, including significant phase delays early in the subjective night.

UR - http://www.scopus.com/inward/record.url?scp=0035827457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035827457&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(01)01796-7

DO - 10.1016/S0304-3940(01)01796-7

M3 - Article

C2 - 11356299

AN - SCOPUS:0035827457

SN - 0304-3940

VL - 305

SP - 25

EP - 28

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Phase-shifting effects of pituitary adenylate cyclase activating polypeptide on hamster wheel-running rhythms

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Access to Document

Other files and links

Fingerprint

Cite this