Abstract
Membrane biology seeks to understand how lipids and proteins within bilayers assemble into large structures such as organelles and the plasma membranes. Historically, lipids were thought to merely provide structural support for bilayer formation and membrane protein function. Research has now revealed that phospholipid metabolism regulates nearly all cellular processes. Sophisticated techniques helped identify >10,000 lipid species suggesting that lipids support many biological processes. Here, we highlight the synthesis of the most abundant glycerophospholipid classes and their distribution in organelles. We review vesicular and nonvesicular transport pathways shuttling lipids between organelles and discuss lipid regulators of membrane trafficking and second messengers in eukaryotic cells.
| Original language | English |
|---|---|
| Pages (from-to) | 6230-6240 |
| Number of pages | 11 |
| Journal | Journal of Biological Chemistry |
| Volume | 293 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - Apr 27 2018 |
| Externally published | Yes |
Bibliographical note
Funding Information:3 Supported in part by scholarships from the Li Ka Shing Knowledge Institute and a Government of Ontario Graduate Scholarship.
Funding Information:
This work was supported in part by Operating Grant MOP-133656 from the Canadian Institutes of Health Research and a Discovery Grant from the Natural Sciences and Engineering Council of Canada (to G. D. F.). The authors declare that they have no conflicts of interest with the contents of this article.
Funding Information:
2 Supported in part by scholarships from the Li Ka Shing Knowledge Institute and the Alzheimer Society of Canada.
Publisher Copyright:
© 2018 by The American Society for Biochemistry and Molecular Biology, Inc.
ASJC Scopus Subject Areas
- Biochemistry
- Molecular Biology
- Cell Biology