Possible association of different G72/G30 SNPs with mood episodes and persecutory delusions in bipolar I Romanian patients

Maria Grigoroiu-Serbanescu; Stefan Herms; Carmen C. Diaconu; Rami Abou Jamra; Sandra Meier; Coralia Bleotu; Ana Iulia Neagu; Dan Prelipceanu; Dorina Sima; Mihail Gherghel; Radu Mihailescu; Marcella Rietschel; Markus M. Nöthen; Sven Cichon; Thomas W. Mühleisen

doi:10.1016/j.pnpbp.2010.03.008

Possible association of different G72/G30 SNPs with mood episodes and persecutory delusions in bipolar I Romanian patients

Maria Grigoroiu-Serbanescu, Stefan Herms, Carmen C. Diaconu, Rami Abou Jamra, Sandra Meier, Coralia Bleotu, Ana Iulia Neagu, Dan Prelipceanu, Dorina Sima, Mihail Gherghel, Radu Mihailescu, Marcella Rietschel, Markus M. Nöthen, Sven Cichon, Thomas W. Mühleisen

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The G72/G30 gene is one of the common loci shared both by schizophrenia and bipolar disorder. Studies accumulating since the discovery of this gene complex produced controversial results in both disorders in different populations. Objective: We investigated the association between the G72/. G30 gene and bipolar I disorder (BPI) in the Romanian population paying special attention to the association of G72/. G30 with lifetime psychosis and in particular with persecutory delusions in BPI patients. Method: Fourteen G72/G30-SNPs were genotyped in a Romanian sample of 198 BPI patients and 180 controls screened for psychiatric disorders. Statistical analysis was performed with FAMHAP and HAPLOVIEW-v3.32. The significance level of the results was corrected through permutations in 100,000 simulations. Results: None of the fourteen SNPs was associated with the global diagnosis of BPI in our total patient sample or with the psychotic BPI subtype. When confining the psychotic phenotype to persecutory delusions, we observed trends to association for SNPs previously associated with schizophrenia and persecutory delusions in BPI [M21 (P=0.080); M22 (P=0.092; P=0.042 under dominant transmission model); M24 (P=0.092)]. Four SNPs reached nominal significance in the non-psychotic BPI subgroup [rs3916965 (M12) (P=0.044), rs1935057 (P=0.037), rs3916967 (M14) (P=0.043), and rs2391191 (M15, non-synonymous) (P=0.043)]. After correction through permutations, the haploblock GA including M14 and M15 showed a trend to association with BPI (P=0.0524; OR=1.82) in the non-psychotic BPI subgroup. Conclusion: We report a potential association of different G72/G30-SNPs with non-psychotic mood episodes and with persecutory delusions in BPI Romanian patients. The results represent a first partial replication of two studies: Williams et al. (2006) and Schulze et al. (2005). The results have just a suggestive value since the Bonferroni correction for multiple testing was not applied.

Original language	English
Pages (from-to)	657-663
Number of pages	7
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.pnpbp.2010.03.008
Publication status	Published - May 2010
Externally published	Yes

Bibliographical note

Funding Information:
The study was supported by the Federal Ministry for Education and Research (BMBF), Germany (NGFNplus MooDS-Project; grant numbers 01GS08144 (M.M. Nöthen) and MOE08/R53 (M.M. Nöthen/ M. Grigoroiu-Serbanescu)). The Romanian Ministry for Education and Research (grants numbers: CNMP-M3-122/2006 and CNMP 42151/2008 ) (M. Grigoroiu-Serbanescu); and the Special Research Fund ( BWTS-23S5528 ) (2002) of the University of Antwerp, Belgium (M.M. Nöthen/ M. Grigoroiu-Serbanescu).

ASJC Scopus Subject Areas

Pharmacology
Biological Psychiatry

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10.1016/j.pnpbp.2010.03.008

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Grigoroiu-Serbanescu, M., Herms, S., Diaconu, C. C., Jamra, R. A., Meier, S., Bleotu, C., Neagu, A. I., Prelipceanu, D., Sima, D., Gherghel, M., Mihailescu, R., Rietschel, M., Nöthen, M. M., Cichon, S., & Mühleisen, T. W. (2010). Possible association of different G72/G30 SNPs with mood episodes and persecutory delusions in bipolar I Romanian patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34(4), 657-663. https://doi.org/10.1016/j.pnpbp.2010.03.008

Grigoroiu-Serbanescu, M, Herms, S, Diaconu, CC, Jamra, RA, Meier, S, Bleotu, C, Neagu, AI, Prelipceanu, D, Sima, D, Gherghel, M, Mihailescu, R, Rietschel, M, Nöthen, MM, Cichon, S & Mühleisen, TW 2010, 'Possible association of different G72/G30 SNPs with mood episodes and persecutory delusions in bipolar I Romanian patients', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 34, no. 4, pp. 657-663. https://doi.org/10.1016/j.pnpbp.2010.03.008

@article{8a09fece662a47d79d30f90dafee11e0,

title = "Possible association of different G72/G30 SNPs with mood episodes and persecutory delusions in bipolar I Romanian patients",

abstract = "The G72/G30 gene is one of the common loci shared both by schizophrenia and bipolar disorder. Studies accumulating since the discovery of this gene complex produced controversial results in both disorders in different populations. Objective: We investigated the association between the G72/. G30 gene and bipolar I disorder (BPI) in the Romanian population paying special attention to the association of G72/. G30 with lifetime psychosis and in particular with persecutory delusions in BPI patients. Method: Fourteen G72/G30-SNPs were genotyped in a Romanian sample of 198 BPI patients and 180 controls screened for psychiatric disorders. Statistical analysis was performed with FAMHAP and HAPLOVIEW-v3.32. The significance level of the results was corrected through permutations in 100,000 simulations. Results: None of the fourteen SNPs was associated with the global diagnosis of BPI in our total patient sample or with the psychotic BPI subtype. When confining the psychotic phenotype to persecutory delusions, we observed trends to association for SNPs previously associated with schizophrenia and persecutory delusions in BPI [M21 (P=0.080); M22 (P=0.092; P=0.042 under dominant transmission model); M24 (P=0.092)]. Four SNPs reached nominal significance in the non-psychotic BPI subgroup [rs3916965 (M12) (P=0.044), rs1935057 (P=0.037), rs3916967 (M14) (P=0.043), and rs2391191 (M15, non-synonymous) (P=0.043)]. After correction through permutations, the haploblock GA including M14 and M15 showed a trend to association with BPI (P=0.0524; OR=1.82) in the non-psychotic BPI subgroup. Conclusion: We report a potential association of different G72/G30-SNPs with non-psychotic mood episodes and with persecutory delusions in BPI Romanian patients. The results represent a first partial replication of two studies: Williams et al. (2006) and Schulze et al. (2005). The results have just a suggestive value since the Bonferroni correction for multiple testing was not applied.",

author = "Maria Grigoroiu-Serbanescu and Stefan Herms and Diaconu, {Carmen C.} and Jamra, {Rami Abou} and Sandra Meier and Coralia Bleotu and Neagu, {Ana Iulia} and Dan Prelipceanu and Dorina Sima and Mihail Gherghel and Radu Mihailescu and Marcella Rietschel and N{\"o}then, {Markus M.} and Sven Cichon and M{\"u}hleisen, {Thomas W.}",

note = "Funding Information: The study was supported by the Federal Ministry for Education and Research (BMBF), Germany (NGFNplus MooDS-Project; grant numbers 01GS08144 (M.M. N{\"o}then) and MOE08/R53 (M.M. N{\"o}then/ M. Grigoroiu-Serbanescu)). The Romanian Ministry for Education and Research (grants numbers: CNMP-M3-122/2006 and CNMP 42151/2008 ) (M. Grigoroiu-Serbanescu); and the Special Research Fund ( BWTS-23S5528 ) (2002) of the University of Antwerp, Belgium (M.M. N{\"o}then/ M. Grigoroiu-Serbanescu). ",

year = "2010",

month = may,

doi = "10.1016/j.pnpbp.2010.03.008",

language = "English",

volume = "34",

pages = "657--663",

journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",

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number = "4",

}

TY - JOUR

T1 - Possible association of different G72/G30 SNPs with mood episodes and persecutory delusions in bipolar I Romanian patients

AU - Grigoroiu-Serbanescu, Maria

AU - Herms, Stefan

AU - Diaconu, Carmen C.

AU - Jamra, Rami Abou

AU - Meier, Sandra

AU - Bleotu, Coralia

AU - Neagu, Ana Iulia

AU - Prelipceanu, Dan

AU - Sima, Dorina

AU - Gherghel, Mihail

AU - Mihailescu, Radu

AU - Rietschel, Marcella

AU - Nöthen, Markus M.

AU - Cichon, Sven

AU - Mühleisen, Thomas W.

N1 - Funding Information: The study was supported by the Federal Ministry for Education and Research (BMBF), Germany (NGFNplus MooDS-Project; grant numbers 01GS08144 (M.M. Nöthen) and MOE08/R53 (M.M. Nöthen/ M. Grigoroiu-Serbanescu)). The Romanian Ministry for Education and Research (grants numbers: CNMP-M3-122/2006 and CNMP 42151/2008 ) (M. Grigoroiu-Serbanescu); and the Special Research Fund ( BWTS-23S5528 ) (2002) of the University of Antwerp, Belgium (M.M. Nöthen/ M. Grigoroiu-Serbanescu).

PY - 2010/5

Y1 - 2010/5

N2 - The G72/G30 gene is one of the common loci shared both by schizophrenia and bipolar disorder. Studies accumulating since the discovery of this gene complex produced controversial results in both disorders in different populations. Objective: We investigated the association between the G72/. G30 gene and bipolar I disorder (BPI) in the Romanian population paying special attention to the association of G72/. G30 with lifetime psychosis and in particular with persecutory delusions in BPI patients. Method: Fourteen G72/G30-SNPs were genotyped in a Romanian sample of 198 BPI patients and 180 controls screened for psychiatric disorders. Statistical analysis was performed with FAMHAP and HAPLOVIEW-v3.32. The significance level of the results was corrected through permutations in 100,000 simulations. Results: None of the fourteen SNPs was associated with the global diagnosis of BPI in our total patient sample or with the psychotic BPI subtype. When confining the psychotic phenotype to persecutory delusions, we observed trends to association for SNPs previously associated with schizophrenia and persecutory delusions in BPI [M21 (P=0.080); M22 (P=0.092; P=0.042 under dominant transmission model); M24 (P=0.092)]. Four SNPs reached nominal significance in the non-psychotic BPI subgroup [rs3916965 (M12) (P=0.044), rs1935057 (P=0.037), rs3916967 (M14) (P=0.043), and rs2391191 (M15, non-synonymous) (P=0.043)]. After correction through permutations, the haploblock GA including M14 and M15 showed a trend to association with BPI (P=0.0524; OR=1.82) in the non-psychotic BPI subgroup. Conclusion: We report a potential association of different G72/G30-SNPs with non-psychotic mood episodes and with persecutory delusions in BPI Romanian patients. The results represent a first partial replication of two studies: Williams et al. (2006) and Schulze et al. (2005). The results have just a suggestive value since the Bonferroni correction for multiple testing was not applied.

AB - The G72/G30 gene is one of the common loci shared both by schizophrenia and bipolar disorder. Studies accumulating since the discovery of this gene complex produced controversial results in both disorders in different populations. Objective: We investigated the association between the G72/. G30 gene and bipolar I disorder (BPI) in the Romanian population paying special attention to the association of G72/. G30 with lifetime psychosis and in particular with persecutory delusions in BPI patients. Method: Fourteen G72/G30-SNPs were genotyped in a Romanian sample of 198 BPI patients and 180 controls screened for psychiatric disorders. Statistical analysis was performed with FAMHAP and HAPLOVIEW-v3.32. The significance level of the results was corrected through permutations in 100,000 simulations. Results: None of the fourteen SNPs was associated with the global diagnosis of BPI in our total patient sample or with the psychotic BPI subtype. When confining the psychotic phenotype to persecutory delusions, we observed trends to association for SNPs previously associated with schizophrenia and persecutory delusions in BPI [M21 (P=0.080); M22 (P=0.092; P=0.042 under dominant transmission model); M24 (P=0.092)]. Four SNPs reached nominal significance in the non-psychotic BPI subgroup [rs3916965 (M12) (P=0.044), rs1935057 (P=0.037), rs3916967 (M14) (P=0.043), and rs2391191 (M15, non-synonymous) (P=0.043)]. After correction through permutations, the haploblock GA including M14 and M15 showed a trend to association with BPI (P=0.0524; OR=1.82) in the non-psychotic BPI subgroup. Conclusion: We report a potential association of different G72/G30-SNPs with non-psychotic mood episodes and with persecutory delusions in BPI Romanian patients. The results represent a first partial replication of two studies: Williams et al. (2006) and Schulze et al. (2005). The results have just a suggestive value since the Bonferroni correction for multiple testing was not applied.

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Possible association of different G72/G30 SNPs with mood episodes and persecutory delusions in bipolar I Romanian patients

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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