Abstract
Modern pharmacology of cannabinoids began in 1964 with the isolation and partial synthesis of delta-9-tetrahydrocannabinol, the main psycho-active agent in herbal cannabis. Since then, potent antinociceptive and antihyperalgesic effects of cannabinoid agonists in animal models of acute and chronic pain; the presence of cannabinoid receptors in pain-processing areas of the brain, spinal cord and periphery; and evidence supporting endogenous modulation of pain systems by cannabinoids has provided support that cannabinoids exhibit significant potential as analgesics. The present article presents an overview of the preclinical science.
| Original language | English |
|---|---|
| Pages (from-to) | 7A-14A |
| Journal | Pain Research and Management |
| Volume | 10 |
| Issue number | SUPPL. A |
| DOIs | |
| Publication status | Published - 2005 |
ASJC Scopus Subject Areas
- Neurology
- Anesthesiology and Pain Medicine