Preferential migration of activated CD4+ and CD8+ T cells in response to MIP-1α and MIP-1β

Dennis D. Taub, Kevin Conlon, Andrew R. Lloyd, Joost J. Oppenheim, David J. Kelvin

Research output: Contribution to journalArticlepeer-review

733 Citations (Scopus)

Abstract

Recombinant human macrophage inflammatory protein-1α (rhMIP-1α) and rhMIP-1β were potent chemoattractants of human T lymphocytes. These rhMIP-1 cytokines attracted only T cells activated by monoclonal antibody to CD3 and did not attract unstimulated lymphocytes. Phenotypic analysis revealed that CD4+ T cells were capable of migrating in response to rhMIP-1β, whereas rhMIP-1α induced chemotaxis of predominantly CD8+ T lymphocytes. Activated naïve and memory T cells also migrated in response to rhMIP-1 cytokines. Furthermore, these cytokines enhanced the ability of T cells to bind to an endothelial cell monolayer. These results suggest that rhMIP-1 cytokines preferentially recruit specific T cell subsets during the evolution of the immune response.

Original languageEnglish
Pages (from-to)355-358
Number of pages4
JournalScience
Volume260
Issue number5106
DOIs
Publication statusPublished - 1993
Externally publishedYes

ASJC Scopus Subject Areas

  • General

PubMed: MeSH publication types

  • Journal Article
  • Research Support, U.S. Gov't, P.H.S.

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