Abstract
Recombinant human macrophage inflammatory protein-1α (rhMIP-1α) and rhMIP-1β were potent chemoattractants of human T lymphocytes. These rhMIP-1 cytokines attracted only T cells activated by monoclonal antibody to CD3 and did not attract unstimulated lymphocytes. Phenotypic analysis revealed that CD4+ T cells were capable of migrating in response to rhMIP-1β, whereas rhMIP-1α induced chemotaxis of predominantly CD8+ T lymphocytes. Activated naïve and memory T cells also migrated in response to rhMIP-1 cytokines. Furthermore, these cytokines enhanced the ability of T cells to bind to an endothelial cell monolayer. These results suggest that rhMIP-1 cytokines preferentially recruit specific T cell subsets during the evolution of the immune response.
Original language | English |
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Pages (from-to) | 355-358 |
Number of pages | 4 |
Journal | Science |
Volume | 260 |
Issue number | 5106 |
DOIs | |
Publication status | Published - 1993 |
Externally published | Yes |
ASJC Scopus Subject Areas
- General
PubMed: MeSH publication types
- Journal Article
- Research Support, U.S. Gov't, P.H.S.