TY - JOUR
T1 - Preliminary clinical evaluation of automated analysis of the sublingual microcirculation in the assessment of patients with septic shock
T2 - Comparison of automated versus semi-automated software
AU - Sharawy, Nivin
AU - Mukhtar, Ahmed
AU - Islam, Sufia
AU - Mahrous, Reham
AU - Mohamed, Hassan
AU - Ali, Mohamed
AU - Hakeem, Amr A.
AU - Hossny, Osama
AU - Refaa, Amera
AU - Saka, Ahmed
AU - Cerny, Vladimir
AU - Whynot, Sara
AU - George, Ronald B.
AU - Lehmann, Christian
N1 - Funding Information:
This study was funded by Stars in Global Health; Grand Challenges Canada.
Publisher Copyright:
© 2017 - IOS Press and the authors. All rights reserved.
PY - 2017
Y1 - 2017
N2 - Introduction: The outcome of patients in septic shock has been shown to be related to changes within the microcirculation. Modern imaging technologies are available to generate high resolution video recordings of the microcirculation in humans. However, evaluation of the microcirculation is not yet implemented in the routine clinical monitoring of critically ill patients. This is mainly due to large amount of time and user interaction required by the current video analysis software. The aim of this study was to validate a newly developed automated method (CCTools®) for microcirculatory analysis of sublingual capillary perfusion in septic patients in comparison to standard semi-automated software (AVA3®). Methods: 204 videos from 47 patients were recorded using incident dark field (IDF) imaging. Total vessel density (TVD), proportion of perfused vessels (PPV), perfused vessel density (PVD), microvascular flowindex (MFI) and heterogeneity index (HI) were measured using AVA3® and CCTools®. Results: Significant differences between the numeric results obtained by the two different software packages were observed. The values for TVD, PVD and MFI were statistically related though. Conclusion: The automated software technique successes to show septic shock induced microcirculation alterations in near real time. However, we found wide degrees of agreement between AVA3® and CCTools® values due to several technical factors that should be considered in the future studies.
AB - Introduction: The outcome of patients in septic shock has been shown to be related to changes within the microcirculation. Modern imaging technologies are available to generate high resolution video recordings of the microcirculation in humans. However, evaluation of the microcirculation is not yet implemented in the routine clinical monitoring of critically ill patients. This is mainly due to large amount of time and user interaction required by the current video analysis software. The aim of this study was to validate a newly developed automated method (CCTools®) for microcirculatory analysis of sublingual capillary perfusion in septic patients in comparison to standard semi-automated software (AVA3®). Methods: 204 videos from 47 patients were recorded using incident dark field (IDF) imaging. Total vessel density (TVD), proportion of perfused vessels (PPV), perfused vessel density (PVD), microvascular flowindex (MFI) and heterogeneity index (HI) were measured using AVA3® and CCTools®. Results: Significant differences between the numeric results obtained by the two different software packages were observed. The values for TVD, PVD and MFI were statistically related though. Conclusion: The automated software technique successes to show septic shock induced microcirculation alterations in near real time. However, we found wide degrees of agreement between AVA3® and CCTools® values due to several technical factors that should be considered in the future studies.
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U2 - 10.3233/CH-179232
DO - 10.3233/CH-179232
M3 - Article
C2 - 28922146
AN - SCOPUS:85045281011
SN - 1386-0291
VL - 67
SP - 489
EP - 498
JO - Clinical Hemorheology and Microcirculation
JF - Clinical Hemorheology and Microcirculation
IS - 3-4
ER -