Abstract
Triclosan is widely used as an antimicrobial agent and preservative that has been hypothesized to play a role in asthma and allergic disease. The limited body of literature regarding the allergenicity of triclosan has not evaluated prenatal exposure and subsequent potential effects on the developing immune system. The objective of the present study was to determine the association between prenatal urinary triclosan concentrations and cord blood immune system biomarker concentrations. Umbilical cord blood samples were obtained from the Maternal-Infant Research on Environmental Chemicals (MIREC) Biobank and were tested for three immune system biomarkers: immunoglobulin E (IgE), thymic stromal lymphopoietin (TSLP), and interleukin-33 (IL-33). Triclosan concentrations were measured in urine at 6-13 weeks gestation. No statistically significant associations were observed between prenatal triclosan concentrations and elevated concentrations of any immune system biomarker (n = 1219 participants). Longitudinal studies are necessary to determine how the observed findings at birth translate into childhood.
| Original language | English |
|---|---|
| Pages (from-to) | 454-457 |
| Number of pages | 4 |
| Journal | International Journal of Hygiene and Environmental Health |
| Volume | 219 |
| Issue number | 4-5 |
| DOIs | |
| Publication status | Published - Jul 1 2016 |
Bibliographical note
Funding Information:We would like to acknowledge the valuable contributions of Yisong Wei, Nong Xu (and other members of the Marshall lab) for their assistance in the analysis of the cord blood samples. We would also like to acknowledge the MIREC Study Group, the MIREC Biobank Committee for granting access to the cord blood samples as well as the MIREC study participants for their dedication. This work was funded by a Category A grant (grant #10012 ) from the Izaak Walton Killam (IWK) Health Centre . The MIREC Study was funded by the Chemicals Management Plan of Health Canada , the Canadian Institutes for Health Research (grant# MOP – 81285 ), and the Ontario Ministry of the Environment .
Publisher Copyright:
© 2016 The Authors.
ASJC Scopus Subject Areas
- Public Health, Environmental and Occupational Health
