Prevalence of conditions associated with human immunodeficiency and hepatits virus infections among persons with haemophilia, 2001-2003

James J. Goedert; Jaime Siegel; Kay Miller; Michael M. Lederman; Alexis Thompson; Brittan Browning; Susan Gamerman; Kevin McRedmond; Janice Withycombe; Ralph Gruppo; Gina Stack; Jeanne Lusher; Linda Percy; Diane Nugent; Marianne McDaniel; Catherine Manno; Regina Butler; Amanda Wade; Anne Angiolillo; Naomi L.C. Luban; Christine Guelcher; Michael Tarantino; Suzi Greer; Joan Gill; Jodie Nelson; Gilbert White; Michael Fried; Aime L. Grimsley; Donna DiMichele; Ilene Goldberg; James French; Sandra Hibner; James Steinberg; Steven Faust; Nigel Key; Vicky Hannemann; Craig M. Kessler; Anastasia E. Lee; M. Elaine Eyster; Kathryn Galli; Gillian Jenkins; Zale P. Bernstein; Linda Belling; Amy Shapiro; Marge Halley; Patti Noblet; Lawrence Jardine; Lori Laudenbach; Richard Lipton; Christine Pece; Cindy A. Leissinger; Cecilia Schmidt; Marcus Carr; Melinda Nolte; Marilyn Manco-Johnson; Sheryl Giambartolomei; Sheldon H. Rubin; Dorine Belliveau; Louis Aledort; Johanna McCarthy; Richard Lemons; Shirley Bleak; Eric Kraut; Leslie Witkoff; Charles Sexauer; Felicia Kiplinger; Arthur Thompson; Charles Cooper; Howard Britton; Kathi Cobb; Hans Joachim Reimers; Judy A. Bagato; Jerry S. Powell; Muriel Herr; Karen Scott; John Hutter; Mary Lou Damiano; Willis Navarro; Jessie Roth; Joseph Palascak; Kenneth Sherman; Madeline Heffner; Jorge DiPaolo; Michael Lammer; Rathi Iyer; Prasad Matthew; Marcia Schwartz; Barbara Konkle; Nirmala Vijayanathan; Marion Dugdale; Donald Lilley; Keith Hoots; Deborah Brown; Megan Ullman; Anne Neff; Steven Klintworth; Hernan Sabio; Anita Smith; Anastasia Karafoulidou

doi:10.1111/j.1365-2516.2005.01138.x

Prevalence of conditions associated with human immunodeficiency and hepatits virus infections among persons with haemophilia, 2001-2003

James J. Goedert, Jaime Siegel, Kay Miller, Michael M. Lederman, Alexis Thompson, Brittan Browning, Susan Gamerman, Kevin McRedmond, Janice Withycombe, Ralph Gruppo, Gina Stack, Jeanne Lusher, Linda Percy, Diane Nugent, Marianne McDaniel, Catherine Manno, Regina Butler, Amanda Wade, Anne Angiolillo, Naomi L.C. LubanChristine Guelcher, Michael Tarantino, Suzi Greer, Joan Gill, Jodie Nelson, Gilbert White, Michael Fried, Aime L. Grimsley, Donna DiMichele, Ilene Goldberg, James French, Sandra Hibner, James Steinberg, Steven Faust, Nigel Key, Vicky Hannemann, Craig M. Kessler, Anastasia E. Lee, M. Elaine Eyster, Kathryn Galli, Gillian Jenkins, Zale P. Bernstein, Linda Belling, Amy Shapiro, Marge Halley, Patti Noblet, Lawrence Jardine, Lori Laudenbach, Richard Lipton, Christine Pece, Cindy A. Leissinger, Cecilia Schmidt, Marcus Carr, Melinda Nolte, Marilyn Manco-Johnson, Sheryl Giambartolomei, Sheldon H. Rubin, Dorine Belliveau, Louis Aledort, Johanna McCarthy, Richard Lemons, Shirley Bleak, Eric Kraut, Leslie Witkoff, Charles Sexauer, Felicia Kiplinger, Arthur Thompson, Charles Cooper, Howard Britton, Kathi Cobb, Hans Joachim Reimers, Judy A. Bagato, Jerry S. Powell, Muriel Herr, Karen Scott, John Hutter, Mary Lou Damiano, Willis Navarro, Jessie Roth, Joseph Palascak, Kenneth Sherman, Madeline Heffner, Jorge DiPaolo, Michael Lammer, Rathi Iyer, Prasad Matthew, Marcia Schwartz, Barbara Konkle, Nirmala Vijayanathan, Marion Dugdale, Donald Lilley, Keith Hoots, Deborah Brown, Megan Ullman, Anne Neff, Steven Klintworth, Hernan Sabio, Anita Smith, Anastasia Karafoulidou

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Before the mid-1980s, haemophilia often was unknowingly treated with contaminated plasma products, resulting in high rates of human immunodeficiency virus (HIV-1), hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. To estimate the impact of these infections, a new cohort was established. All HCV-seropositive patients, age 13-88 years, at 52 comprehensive haemophilia treatment centres were eligible. Cross-sectional data collected during April 2001 to January 2004 (median June 2002) were analysed. Plasma HIV-1 and HCV RNA were quantified by polymerase chain reaction. Highly active antiretroviral therapy (HAART) was defined as use of at least three recommended medications. Among 2069 participants, 620 (30%) had HIV-1. Of 1955 with known HBV status, 814 (42%) had resolved HBV and 90 (4.6%) were HBV carriers. Although 80% of the HIV-1-positive participants had ≥200 CD4⁺ cells μL^-1, only 59% were on HAART. HIV-1 RNA was undetectable in 23% of those not taking antiretroviral medications. Most (72%) participants had received no anti-HCV therapy. HCV RNA was detected less frequently (59%) among participants treated with standard interferon plus ribavirin (P = 0.0001) and more frequently among HIV-1-positive than HIV-1-negative participants (85% vs. 70%, P < 0.0001). HIV-1-positive participants were more likely to have pancytopenia and subclinical hepatic abnormalities, as well as persistent jaundice, hepatomegaly, splenomegaly and ascites. HAART recipients did not differ from HIV-negative participants in the prevalence of ascites. The clinical abnormalities were more prevalent with older age but were not confounded by HBV status or self-reported alcohol consumption. Eleven participants presented with or previously had hepatocellular carcinoma or non-Hodgkin lymphoma. Although prospective analysis is needed, our data reveal the scale of hepatic and haematological disease that is likely to manifest in the adult haemophilic population during the coming years unless most of them are successfully treated for HIV-1, HCV or both.

Original language	English
Pages (from-to)	516-528
Number of pages	13
Journal	Haemophilia
Volume	11
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2516.2005.01138.x
Publication status	Published - Sept 2005
Externally published	Yes

ASJC Scopus Subject Areas

Hematology
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1365-2516.2005.01138.x

Cite this

Goedert, J. J., Siegel, J., Miller, K., Lederman, M. M., Thompson, A., Browning, B., Gamerman, S., McRedmond, K., Withycombe, J., Gruppo, R., Stack, G., Lusher, J., Percy, L., Nugent, D., McDaniel, M., Manno, C., Butler, R., Wade, A., Angiolillo, A., ... Karafoulidou, A. (2005). Prevalence of conditions associated with human immunodeficiency and hepatits virus infections among persons with haemophilia, 2001-2003. Haemophilia, 11(5), 516-528. https://doi.org/10.1111/j.1365-2516.2005.01138.x

Goedert, JJ, Siegel, J, Miller, K, Lederman, MM, Thompson, A, Browning, B, Gamerman, S, McRedmond, K, Withycombe, J, Gruppo, R, Stack, G, Lusher, J, Percy, L, Nugent, D, McDaniel, M, Manno, C, Butler, R, Wade, A, Angiolillo, A, Luban, NLC, Guelcher, C, Tarantino, M, Greer, S, Gill, J, Nelson, J, White, G, Fried, M, Grimsley, AL, DiMichele, D, Goldberg, I, French, J, Hibner, S, Steinberg, J, Faust, S, Key, N, Hannemann, V, Kessler, CM, Lee, AE, Eyster, ME, Galli, K, Jenkins, G, Bernstein, ZP, Belling, L, Shapiro, A, Halley, M, Noblet, P, Jardine, L, Laudenbach, L, Lipton, R, Pece, C, Leissinger, CA, Schmidt, C, Carr, M, Nolte, M, Manco-Johnson, M, Giambartolomei, S, Rubin, SH, Belliveau, D, Aledort, L, McCarthy, J, Lemons, R, Bleak, S, Kraut, E, Witkoff, L, Sexauer, C, Kiplinger, F, Thompson, A, Cooper, C, Britton, H, Cobb, K, Reimers, HJ, Bagato, JA, Powell, JS, Herr, M, Scott, K, Hutter, J, Damiano, ML, Navarro, W, Roth, J, Palascak, J, Sherman, K, Heffner, M, DiPaolo, J, Lammer, M, Iyer, R, Matthew, P, Schwartz, M, Konkle, B, Vijayanathan, N, Dugdale, M, Lilley, D, Hoots, K, Brown, D, Ullman, M, Neff, A, Klintworth, S, Sabio, H, Smith, A & Karafoulidou, A 2005, 'Prevalence of conditions associated with human immunodeficiency and hepatits virus infections among persons with haemophilia, 2001-2003', Haemophilia, vol. 11, no. 5, pp. 516-528. https://doi.org/10.1111/j.1365-2516.2005.01138.x

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title = "Prevalence of conditions associated with human immunodeficiency and hepatits virus infections among persons with haemophilia, 2001-2003",

abstract = "Before the mid-1980s, haemophilia often was unknowingly treated with contaminated plasma products, resulting in high rates of human immunodeficiency virus (HIV-1), hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. To estimate the impact of these infections, a new cohort was established. All HCV-seropositive patients, age 13-88 years, at 52 comprehensive haemophilia treatment centres were eligible. Cross-sectional data collected during April 2001 to January 2004 (median June 2002) were analysed. Plasma HIV-1 and HCV RNA were quantified by polymerase chain reaction. Highly active antiretroviral therapy (HAART) was defined as use of at least three recommended medications. Among 2069 participants, 620 (30%) had HIV-1. Of 1955 with known HBV status, 814 (42%) had resolved HBV and 90 (4.6%) were HBV carriers. Although 80% of the HIV-1-positive participants had ≥200 CD4+ cells μL-1, only 59% were on HAART. HIV-1 RNA was undetectable in 23% of those not taking antiretroviral medications. Most (72%) participants had received no anti-HCV therapy. HCV RNA was detected less frequently (59%) among participants treated with standard interferon plus ribavirin (P = 0.0001) and more frequently among HIV-1-positive than HIV-1-negative participants (85% vs. 70%, P < 0.0001). HIV-1-positive participants were more likely to have pancytopenia and subclinical hepatic abnormalities, as well as persistent jaundice, hepatomegaly, splenomegaly and ascites. HAART recipients did not differ from HIV-negative participants in the prevalence of ascites. The clinical abnormalities were more prevalent with older age but were not confounded by HBV status or self-reported alcohol consumption. Eleven participants presented with or previously had hepatocellular carcinoma or non-Hodgkin lymphoma. Although prospective analysis is needed, our data reveal the scale of hepatic and haematological disease that is likely to manifest in the adult haemophilic population during the coming years unless most of them are successfully treated for HIV-1, HCV or both.",

author = "Goedert, {James J.} and Jaime Siegel and Kay Miller and Lederman, {Michael M.} and Alexis Thompson and Brittan Browning and Susan Gamerman and Kevin McRedmond and Janice Withycombe and Ralph Gruppo and Gina Stack and Jeanne Lusher and Linda Percy and Diane Nugent and Marianne McDaniel and Catherine Manno and Regina Butler and Amanda Wade and Anne Angiolillo and Luban, {Naomi L.C.} and Christine Guelcher and Michael Tarantino and Suzi Greer and Joan Gill and Jodie Nelson and Gilbert White and Michael Fried and Grimsley, {Aime L.} and Donna DiMichele and Ilene Goldberg and James French and Sandra Hibner and James Steinberg and Steven Faust and Nigel Key and Vicky Hannemann and Kessler, {Craig M.} and Lee, {Anastasia E.} and Eyster, {M. Elaine} and Kathryn Galli and Gillian Jenkins and Bernstein, {Zale P.} and Linda Belling and Amy Shapiro and Marge Halley and Patti Noblet and Lawrence Jardine and Lori Laudenbach and Richard Lipton and Christine Pece and Leissinger, {Cindy A.} and Cecilia Schmidt and Marcus Carr and Melinda Nolte and Marilyn Manco-Johnson and Sheryl Giambartolomei and Rubin, {Sheldon H.} and Dorine Belliveau and Louis Aledort and Johanna McCarthy and Richard Lemons and Shirley Bleak and Eric Kraut and Leslie Witkoff and Charles Sexauer and Felicia Kiplinger and Arthur Thompson and Charles Cooper and Howard Britton and Kathi Cobb and Reimers, {Hans Joachim} and Bagato, {Judy A.} and Powell, {Jerry S.} and Muriel Herr and Karen Scott and John Hutter and Damiano, {Mary Lou} and Willis Navarro and Jessie Roth and Joseph Palascak and Kenneth Sherman and Madeline Heffner and Jorge DiPaolo and Michael Lammer and Rathi Iyer and Prasad Matthew and Marcia Schwartz and Barbara Konkle and Nirmala Vijayanathan and Marion Dugdale and Donald Lilley and Keith Hoots and Deborah Brown and Megan Ullman and Anne Neff and Steven Klintworth and Hernan Sabio and Anita Smith and Anastasia Karafoulidou",

year = "2005",

month = sep,

doi = "10.1111/j.1365-2516.2005.01138.x",

language = "English",

volume = "11",

pages = "516--528",

journal = "Haemophilia",

issn = "1351-8216",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Prevalence of conditions associated with human immunodeficiency and hepatits virus infections among persons with haemophilia, 2001-2003

AU - Goedert, James J.

AU - Siegel, Jaime

AU - Miller, Kay

AU - Lederman, Michael M.

AU - Thompson, Alexis

AU - Browning, Brittan

AU - Gamerman, Susan

AU - McRedmond, Kevin

AU - Withycombe, Janice

AU - Gruppo, Ralph

AU - Stack, Gina

AU - Lusher, Jeanne

AU - Percy, Linda

AU - Nugent, Diane

AU - McDaniel, Marianne

AU - Manno, Catherine

AU - Butler, Regina

AU - Wade, Amanda

AU - Angiolillo, Anne

AU - Luban, Naomi L.C.

AU - Guelcher, Christine

AU - Tarantino, Michael

AU - Greer, Suzi

AU - Gill, Joan

AU - Nelson, Jodie

AU - White, Gilbert

AU - Fried, Michael

AU - Grimsley, Aime L.

AU - DiMichele, Donna

AU - Goldberg, Ilene

AU - French, James

AU - Hibner, Sandra

AU - Steinberg, James

AU - Faust, Steven

AU - Key, Nigel

AU - Hannemann, Vicky

AU - Kessler, Craig M.

AU - Lee, Anastasia E.

AU - Eyster, M. Elaine

AU - Galli, Kathryn

AU - Jenkins, Gillian

AU - Bernstein, Zale P.

AU - Belling, Linda

AU - Shapiro, Amy

AU - Halley, Marge

AU - Noblet, Patti

AU - Jardine, Lawrence

AU - Laudenbach, Lori

AU - Lipton, Richard

AU - Pece, Christine

AU - Leissinger, Cindy A.

AU - Schmidt, Cecilia

AU - Carr, Marcus

AU - Nolte, Melinda

AU - Manco-Johnson, Marilyn

AU - Giambartolomei, Sheryl

AU - Rubin, Sheldon H.

AU - Belliveau, Dorine

AU - Aledort, Louis

AU - McCarthy, Johanna

AU - Lemons, Richard

AU - Bleak, Shirley

AU - Kraut, Eric

AU - Witkoff, Leslie

AU - Sexauer, Charles

AU - Kiplinger, Felicia

AU - Thompson, Arthur

AU - Cooper, Charles

AU - Britton, Howard

AU - Cobb, Kathi

AU - Reimers, Hans Joachim

AU - Bagato, Judy A.

AU - Powell, Jerry S.

AU - Herr, Muriel

AU - Scott, Karen

AU - Hutter, John

AU - Damiano, Mary Lou

AU - Navarro, Willis

AU - Roth, Jessie

AU - Palascak, Joseph

AU - Sherman, Kenneth

AU - Heffner, Madeline

AU - DiPaolo, Jorge

AU - Lammer, Michael

AU - Iyer, Rathi

AU - Matthew, Prasad

AU - Schwartz, Marcia

AU - Konkle, Barbara

AU - Vijayanathan, Nirmala

AU - Dugdale, Marion

AU - Lilley, Donald

AU - Hoots, Keith

AU - Brown, Deborah

AU - Ullman, Megan

AU - Neff, Anne

AU - Klintworth, Steven

AU - Sabio, Hernan

AU - Smith, Anita

AU - Karafoulidou, Anastasia

PY - 2005/9

Y1 - 2005/9

N2 - Before the mid-1980s, haemophilia often was unknowingly treated with contaminated plasma products, resulting in high rates of human immunodeficiency virus (HIV-1), hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. To estimate the impact of these infections, a new cohort was established. All HCV-seropositive patients, age 13-88 years, at 52 comprehensive haemophilia treatment centres were eligible. Cross-sectional data collected during April 2001 to January 2004 (median June 2002) were analysed. Plasma HIV-1 and HCV RNA were quantified by polymerase chain reaction. Highly active antiretroviral therapy (HAART) was defined as use of at least three recommended medications. Among 2069 participants, 620 (30%) had HIV-1. Of 1955 with known HBV status, 814 (42%) had resolved HBV and 90 (4.6%) were HBV carriers. Although 80% of the HIV-1-positive participants had ≥200 CD4+ cells μL-1, only 59% were on HAART. HIV-1 RNA was undetectable in 23% of those not taking antiretroviral medications. Most (72%) participants had received no anti-HCV therapy. HCV RNA was detected less frequently (59%) among participants treated with standard interferon plus ribavirin (P = 0.0001) and more frequently among HIV-1-positive than HIV-1-negative participants (85% vs. 70%, P < 0.0001). HIV-1-positive participants were more likely to have pancytopenia and subclinical hepatic abnormalities, as well as persistent jaundice, hepatomegaly, splenomegaly and ascites. HAART recipients did not differ from HIV-negative participants in the prevalence of ascites. The clinical abnormalities were more prevalent with older age but were not confounded by HBV status or self-reported alcohol consumption. Eleven participants presented with or previously had hepatocellular carcinoma or non-Hodgkin lymphoma. Although prospective analysis is needed, our data reveal the scale of hepatic and haematological disease that is likely to manifest in the adult haemophilic population during the coming years unless most of them are successfully treated for HIV-1, HCV or both.

AB - Before the mid-1980s, haemophilia often was unknowingly treated with contaminated plasma products, resulting in high rates of human immunodeficiency virus (HIV-1), hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. To estimate the impact of these infections, a new cohort was established. All HCV-seropositive patients, age 13-88 years, at 52 comprehensive haemophilia treatment centres were eligible. Cross-sectional data collected during April 2001 to January 2004 (median June 2002) were analysed. Plasma HIV-1 and HCV RNA were quantified by polymerase chain reaction. Highly active antiretroviral therapy (HAART) was defined as use of at least three recommended medications. Among 2069 participants, 620 (30%) had HIV-1. Of 1955 with known HBV status, 814 (42%) had resolved HBV and 90 (4.6%) were HBV carriers. Although 80% of the HIV-1-positive participants had ≥200 CD4+ cells μL-1, only 59% were on HAART. HIV-1 RNA was undetectable in 23% of those not taking antiretroviral medications. Most (72%) participants had received no anti-HCV therapy. HCV RNA was detected less frequently (59%) among participants treated with standard interferon plus ribavirin (P = 0.0001) and more frequently among HIV-1-positive than HIV-1-negative participants (85% vs. 70%, P < 0.0001). HIV-1-positive participants were more likely to have pancytopenia and subclinical hepatic abnormalities, as well as persistent jaundice, hepatomegaly, splenomegaly and ascites. HAART recipients did not differ from HIV-negative participants in the prevalence of ascites. The clinical abnormalities were more prevalent with older age but were not confounded by HBV status or self-reported alcohol consumption. Eleven participants presented with or previously had hepatocellular carcinoma or non-Hodgkin lymphoma. Although prospective analysis is needed, our data reveal the scale of hepatic and haematological disease that is likely to manifest in the adult haemophilic population during the coming years unless most of them are successfully treated for HIV-1, HCV or both.

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DO - 10.1111/j.1365-2516.2005.01138.x

M3 - Article

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AN - SCOPUS:24644456388

SN - 1351-8216

VL - 11

SP - 516

EP - 528

JO - Haemophilia

JF - Haemophilia

IS - 5

ER -

Prevalence of conditions associated with human immunodeficiency and hepatits virus infections among persons with haemophilia, 2001-2003

Abstract

ASJC Scopus Subject Areas

UN SDGs

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