Prevention and management of neonatal herpes simplex virus infections

Upton D. Allen; Joan L. Robinson; Robert Bortolussi; Natalie A. Bridger; Jane C. Finlay; Susanna Martin; Jane C. McDonald; Heather Onyett; Marina I. Salvadori; Otto G. Vanderkooi; Noni E. MacDonald; Michael Brady; Janet Dollin; Charles P.S. Hui; Nicole Le Saux; Dorothy L. Moore; John S. Spika

doi:10.1093/pch/19.4.201

Prevention and management of neonatal herpes simplex virus infections

Upton D. Allen, Joan L. Robinson, Robert Bortolussi, Natalie A. Bridger, Jane C. Finlay, Susanna Martin, Jane C. McDonald, Heather Onyett, Marina I. Salvadori, Otto G. Vanderkooi, Noni E. MacDonald, Michael Brady, Janet Dollin, Charles P.S. Hui, Nicole Le Saux, Dorothy L. Moore, John S. Spika

Medicine

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Human herpes simplex virus (HSV) infection in neonates can result in devastating outcomes, including mortality and significant morbidity. All infants are potentially at risk for neonatal HSV infection. This position statement reviews epidemiology, transmission and risk factors, with a focus on intrapartum infection. It considers diagnosis and prognosis according to infection category, along with testing modalities and limitations. Recommendations for managing newborns known to have been exposed intrapartum to HSV are based on expert opinion because a randomized trial to compare management options is not feasible. Guidance is provided for the empirical management of infants with suspected clinical sepsis, including those who do not respond to antibacterial therapy. The present statement replaces a 2006 position statement by the Canadian Paediatric Society.

Original language	English
Pages (from-to)	201-206
Number of pages	6
Journal	Paediatrics and Child Health
Volume	19
Issue number	4
DOIs	https://doi.org/10.1093/pch/19.4.201
Publication status	Published - Apr 2014

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health

PubMed: MeSH publication types

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/pch/19.4.201

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Allen, U. D., Robinson, J. L., Bortolussi, R., Bridger, N. A., Finlay, J. C., Martin, S., McDonald, J. C., Onyett, H., Salvadori, M. I., Vanderkooi, O. G., MacDonald, N. E., Brady, M., Dollin, J., Hui, C. P. S., Le Saux, N., Moore, D. L., & Spika, J. S. (2014). Prevention and management of neonatal herpes simplex virus infections. Paediatrics and Child Health, 19(4), 201-206. https://doi.org/10.1093/pch/19.4.201

Allen, UD, Robinson, JL, Bortolussi, R, Bridger, NA, Finlay, JC, Martin, S, McDonald, JC, Onyett, H, Salvadori, MI, Vanderkooi, OG, MacDonald, NE, Brady, M, Dollin, J, Hui, CPS, Le Saux, N, Moore, DL & Spika, JS 2014, 'Prevention and management of neonatal herpes simplex virus infections', Paediatrics and Child Health, vol. 19, no. 4, pp. 201-206. https://doi.org/10.1093/pch/19.4.201

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abstract = "Human herpes simplex virus (HSV) infection in neonates can result in devastating outcomes, including mortality and significant morbidity. All infants are potentially at risk for neonatal HSV infection. This position statement reviews epidemiology, transmission and risk factors, with a focus on intrapartum infection. It considers diagnosis and prognosis according to infection category, along with testing modalities and limitations. Recommendations for managing newborns known to have been exposed intrapartum to HSV are based on expert opinion because a randomized trial to compare management options is not feasible. Guidance is provided for the empirical management of infants with suspected clinical sepsis, including those who do not respond to antibacterial therapy. The present statement replaces a 2006 position statement by the Canadian Paediatric Society.",

author = "Allen, {Upton D.} and Robinson, {Joan L.} and Robert Bortolussi and Bridger, {Natalie A.} and Finlay, {Jane C.} and Susanna Martin and McDonald, {Jane C.} and Heather Onyett and Salvadori, {Marina I.} and Vanderkooi, {Otto G.} and MacDonald, {Noni E.} and Michael Brady and Janet Dollin and Hui, {Charles P.S.} and {Le Saux}, Nicole and Moore, {Dorothy L.} and Spika, {John S.}",

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AU - Martin, Susanna

AU - McDonald, Jane C.

AU - Onyett, Heather

AU - Salvadori, Marina I.

AU - Vanderkooi, Otto G.

AU - MacDonald, Noni E.

AU - Brady, Michael

AU - Dollin, Janet

AU - Hui, Charles P.S.

AU - Le Saux, Nicole

AU - Moore, Dorothy L.

AU - Spika, John S.

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AB - Human herpes simplex virus (HSV) infection in neonates can result in devastating outcomes, including mortality and significant morbidity. All infants are potentially at risk for neonatal HSV infection. This position statement reviews epidemiology, transmission and risk factors, with a focus on intrapartum infection. It considers diagnosis and prognosis according to infection category, along with testing modalities and limitations. Recommendations for managing newborns known to have been exposed intrapartum to HSV are based on expert opinion because a randomized trial to compare management options is not feasible. Guidance is provided for the empirical management of infants with suspected clinical sepsis, including those who do not respond to antibacterial therapy. The present statement replaces a 2006 position statement by the Canadian Paediatric Society.

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Prevention and management of neonatal herpes simplex virus infections

Abstract

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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