Prospective memory in HIV-1 infection

Catherine L. Carey; Steven Paul Woods; Julie D. Rippeth; Robert K. Heaton; Igor Grant; Igor Grant; J. Hampton Atkinson; J. Allen McCutchan; Thomas D. Marcotte; Mark R. Wallace; J. Allen McCutchan; Ronald J. Ellis; Scott Letendre; Rachel Schrier; Robert K. Heaton; Mariana Cherner; Julie Rippeth; Joseph Sadek; Steven Paul Woods; Corinna Young; Terry Jernigan; John Hesselink; Michael J. Taylor; Eliezer Masliah; Dianne Langford; J. Allen McCutchan; J. Hampton Atkinson; Ronald J. Ellis; Scott Letendre; Daniel R. Masys; Michelle Frybarger; Ian Abramson; Deborah Lazzaretto

doi:10.1080/13803390590949494

Prospective memory in HIV-1 infection

Catherine L. Carey, Steven Paul Woods, Julie D. Rippeth, Robert K. Heaton, Igor Grant, Igor Grant, J. Hampton Atkinson, J. Allen McCutchan, Thomas D. Marcotte, Mark R. Wallace, J. Allen McCutchan, Ronald J. Ellis, Scott Letendre, Rachel Schrier, Robert K. Heaton, Mariana Cherner, Julie Rippeth, Joseph Sadek, Steven Paul Woods, Corinna YoungTerry Jernigan, John Hesselink, Michael J. Taylor, Eliezer Masliah, Dianne Langford, J. Allen McCutchan, J. Hampton Atkinson, Ronald J. Ellis, Scott Letendre, Daniel R. Masys, Michelle Frybarger, Ian Abramson, Deborah Lazzaretto

Medicine

Research output: Contribution to journal › Article › peer-review

117 Citations (Scopus)

Abstract

The cognitive deficits associated with HIV-1 infection are thought to primarily reflect neuropathophysiology within the fronto-striato-thalamo-cortical circuits. Prospective memory (ProM) is a cognitive function that is largely dependent on prefronto-striatal circuits, but has not previously been examined in an HIV-1 sample. A form of episodic memory, ProM involves the complex processes of forming, monitoring, and executing future intentions vis-à-vis ongoing distractions. The current study examined ProM in 42 participants with HIV-1 infection and 29 demographically similar seronegative healthy comparison (HC) subjects. The HIV-1 sample demonstrated deficits in time-and event-based ProM, as well as more frequent 24-hour delay ProM failures and task substitution errors relative to the HC group. In contrast, there were no significant differences in recognition performance, indicating that the HIV-1 group was able to accurately retain and recognize the ProM intention when retrieval demands were minimized. Secondary analyses revealed that ProM performance correlated with validated clinical measures of executive functions, episodic memory (free recall), and verbal working memory, but not with tests of semantic memory, retention, or recognition discrimination. Taken together, these findings indicate that HIV-1 infection is associated with ProM impairment that is primarily driven by a breakdown in the strategic (i.e., executive) aspects of retrieving future intentions, which is consistent with a prefronto-striatal circuit neuropathogenesis.

Original language	English
Pages (from-to)	536-548
Number of pages	13
Journal	Journal of Clinical and Experimental Neuropsychology
Volume	28
Issue number	4
DOIs	https://doi.org/10.1080/13803390590949494
Publication status	Published - May 2006

Bibliographical note

Funding Information:
The research described was also supported by DA12065, MH59745, MH62512, and MH073419 from the National Institutes of Health. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, nor the United States Government. The authors extend their gratitude to Sarah Raskin, Ph.D. for her generosity in supplying a complementary version of the MIST for use in this study. We also thank Jennifer Marquie, Emily Conover, Emily Jo Rajotte, J. Cobb Scott, and Richard Seghers for their assistance with data collection and coding. Aspects of these data were presented as part of a symposium at the 33rd Annual Meeting of the International Neuropsychological Society in St. Louis, MO.

ASJC Scopus Subject Areas

Clinical Psychology
Neurology
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Carey, C. L., Woods, S. P., Rippeth, J. D., Heaton, R. K., Grant, I., Grant, I., Atkinson, J. H., McCutchan, J. A., Marcotte, T. D., Wallace, M. R., McCutchan, J. A., Ellis, R. J., Letendre, S., Schrier, R., Heaton, R. K., Cherner, M., Rippeth, J., Sadek, J., Woods, S. P., ... Lazzaretto, D. (2006). Prospective memory in HIV-1 infection. Journal of Clinical and Experimental Neuropsychology, 28(4), 536-548. https://doi.org/10.1080/13803390590949494

Carey, CL, Woods, SP, Rippeth, JD, Heaton, RK, Grant, I, Grant, I, Atkinson, JH, McCutchan, JA, Marcotte, TD, Wallace, MR, McCutchan, JA, Ellis, RJ, Letendre, S, Schrier, R, Heaton, RK, Cherner, M, Rippeth, J, Sadek, J, Woods, SP, Young, C, Jernigan, T, Hesselink, J, Taylor, MJ, Masliah, E, Langford, D, McCutchan, JA, Atkinson, JH, Ellis, RJ, Letendre, S, Masys, DR, Frybarger, M, Abramson, I & Lazzaretto, D 2006, 'Prospective memory in HIV-1 infection', Journal of Clinical and Experimental Neuropsychology, vol. 28, no. 4, pp. 536-548. https://doi.org/10.1080/13803390590949494

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title = "Prospective memory in HIV-1 infection",

abstract = "The cognitive deficits associated with HIV-1 infection are thought to primarily reflect neuropathophysiology within the fronto-striato-thalamo-cortical circuits. Prospective memory (ProM) is a cognitive function that is largely dependent on prefronto-striatal circuits, but has not previously been examined in an HIV-1 sample. A form of episodic memory, ProM involves the complex processes of forming, monitoring, and executing future intentions vis-{\`a}-vis ongoing distractions. The current study examined ProM in 42 participants with HIV-1 infection and 29 demographically similar seronegative healthy comparison (HC) subjects. The HIV-1 sample demonstrated deficits in time-and event-based ProM, as well as more frequent 24-hour delay ProM failures and task substitution errors relative to the HC group. In contrast, there were no significant differences in recognition performance, indicating that the HIV-1 group was able to accurately retain and recognize the ProM intention when retrieval demands were minimized. Secondary analyses revealed that ProM performance correlated with validated clinical measures of executive functions, episodic memory (free recall), and verbal working memory, but not with tests of semantic memory, retention, or recognition discrimination. Taken together, these findings indicate that HIV-1 infection is associated with ProM impairment that is primarily driven by a breakdown in the strategic (i.e., executive) aspects of retrieving future intentions, which is consistent with a prefronto-striatal circuit neuropathogenesis.",

author = "Carey, {Catherine L.} and Woods, {Steven Paul} and Rippeth, {Julie D.} and Heaton, {Robert K.} and Igor Grant and Igor Grant and Atkinson, {J. Hampton} and McCutchan, {J. Allen} and Marcotte, {Thomas D.} and Wallace, {Mark R.} and McCutchan, {J. Allen} and Ellis, {Ronald J.} and Scott Letendre and Rachel Schrier and Heaton, {Robert K.} and Mariana Cherner and Julie Rippeth and Joseph Sadek and Woods, {Steven Paul} and Corinna Young and Terry Jernigan and John Hesselink and Taylor, {Michael J.} and Eliezer Masliah and Dianne Langford and McCutchan, {J. Allen} and Atkinson, {J. Hampton} and Ellis, {Ronald J.} and Scott Letendre and Masys, {Daniel R.} and Michelle Frybarger and Ian Abramson and Deborah Lazzaretto",

note = "Funding Information: The research described was also supported by DA12065, MH59745, MH62512, and MH073419 from the National Institutes of Health. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, nor the United States Government. The authors extend their gratitude to Sarah Raskin, Ph.D. for her generosity in supplying a complementary version of the MIST for use in this study. We also thank Jennifer Marquie, Emily Conover, Emily Jo Rajotte, J. Cobb Scott, and Richard Seghers for their assistance with data collection and coding. Aspects of these data were presented as part of a symposium at the 33rd Annual Meeting of the International Neuropsychological Society in St. Louis, MO.",

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AU - Carey, Catherine L.

AU - Woods, Steven Paul

AU - Rippeth, Julie D.

AU - Heaton, Robert K.

AU - Grant, Igor

AU - Atkinson, J. Hampton

AU - McCutchan, J. Allen

AU - Marcotte, Thomas D.

AU - Wallace, Mark R.

AU - McCutchan, J. Allen

AU - Ellis, Ronald J.

AU - Letendre, Scott

AU - Schrier, Rachel

AU - Heaton, Robert K.

AU - Cherner, Mariana

AU - Rippeth, Julie

AU - Sadek, Joseph

AU - Woods, Steven Paul

AU - Young, Corinna

AU - Jernigan, Terry

AU - Hesselink, John

AU - Taylor, Michael J.

AU - Masliah, Eliezer

AU - Langford, Dianne

AU - McCutchan, J. Allen

AU - Atkinson, J. Hampton

AU - Ellis, Ronald J.

AU - Letendre, Scott

AU - Masys, Daniel R.

AU - Frybarger, Michelle

AU - Abramson, Ian

AU - Lazzaretto, Deborah

N1 - Funding Information: The research described was also supported by DA12065, MH59745, MH62512, and MH073419 from the National Institutes of Health. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, nor the United States Government. The authors extend their gratitude to Sarah Raskin, Ph.D. for her generosity in supplying a complementary version of the MIST for use in this study. We also thank Jennifer Marquie, Emily Conover, Emily Jo Rajotte, J. Cobb Scott, and Richard Seghers for their assistance with data collection and coding. Aspects of these data were presented as part of a symposium at the 33rd Annual Meeting of the International Neuropsychological Society in St. Louis, MO.

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N2 - The cognitive deficits associated with HIV-1 infection are thought to primarily reflect neuropathophysiology within the fronto-striato-thalamo-cortical circuits. Prospective memory (ProM) is a cognitive function that is largely dependent on prefronto-striatal circuits, but has not previously been examined in an HIV-1 sample. A form of episodic memory, ProM involves the complex processes of forming, monitoring, and executing future intentions vis-à-vis ongoing distractions. The current study examined ProM in 42 participants with HIV-1 infection and 29 demographically similar seronegative healthy comparison (HC) subjects. The HIV-1 sample demonstrated deficits in time-and event-based ProM, as well as more frequent 24-hour delay ProM failures and task substitution errors relative to the HC group. In contrast, there were no significant differences in recognition performance, indicating that the HIV-1 group was able to accurately retain and recognize the ProM intention when retrieval demands were minimized. Secondary analyses revealed that ProM performance correlated with validated clinical measures of executive functions, episodic memory (free recall), and verbal working memory, but not with tests of semantic memory, retention, or recognition discrimination. Taken together, these findings indicate that HIV-1 infection is associated with ProM impairment that is primarily driven by a breakdown in the strategic (i.e., executive) aspects of retrieving future intentions, which is consistent with a prefronto-striatal circuit neuropathogenesis.

AB - The cognitive deficits associated with HIV-1 infection are thought to primarily reflect neuropathophysiology within the fronto-striato-thalamo-cortical circuits. Prospective memory (ProM) is a cognitive function that is largely dependent on prefronto-striatal circuits, but has not previously been examined in an HIV-1 sample. A form of episodic memory, ProM involves the complex processes of forming, monitoring, and executing future intentions vis-à-vis ongoing distractions. The current study examined ProM in 42 participants with HIV-1 infection and 29 demographically similar seronegative healthy comparison (HC) subjects. The HIV-1 sample demonstrated deficits in time-and event-based ProM, as well as more frequent 24-hour delay ProM failures and task substitution errors relative to the HC group. In contrast, there were no significant differences in recognition performance, indicating that the HIV-1 group was able to accurately retain and recognize the ProM intention when retrieval demands were minimized. Secondary analyses revealed that ProM performance correlated with validated clinical measures of executive functions, episodic memory (free recall), and verbal working memory, but not with tests of semantic memory, retention, or recognition discrimination. Taken together, these findings indicate that HIV-1 infection is associated with ProM impairment that is primarily driven by a breakdown in the strategic (i.e., executive) aspects of retrieving future intentions, which is consistent with a prefronto-striatal circuit neuropathogenesis.

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Prospective memory in HIV-1 infection

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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