Prospects for defined epitope vaccines for respiratory syncytial virus

Robert Anderson, Yan Huang, Joanne M. Langley

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)

Abstract

The history of vaccines for respiratory syncytial virus (RSV) illustrates the complex immunity and immunopathology to this ubiquitous virus, starting from the failed formalin-inactivated vaccine trials performed in the 1960s. An attractive alternative to traditional live or killed virus vaccines is a defined vaccine composed of discrete antigenic epitopes for which immunological activities have been characterized as comprehensively as possible. Here we present cumulative data on murine and human CD4, CD8 and neutralization epitopes identified in RSV proteins along with information regarding their associated immune responses and host-dependent variability. Identification and characterization of RSV epitopes is a rapidly expanding topic of research with potential contributions to the tailored design of improved safe and effective vaccines.

Original languageEnglish
Pages (from-to)585-602
Number of pages18
JournalFuture Microbiology
Volume5
Issue number4
DOIs
Publication statusPublished - Apr 2010

ASJC Scopus Subject Areas

  • Microbiology
  • Microbiology (medical)

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