Protocol for SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home): feasibility of a home-based double-blind randomised controlled trial to improve gait and cognition in individuals at risk for dementia

Chris McGibbon; Pam Jarrett; Grant Handrigan; Danielle Bouchard; Carole C.C. Tranchant; Andrew M. Sexton; Linda Yetman; Bryn Robinson; Stephanie Crapoulet; Ludivine Chamard-Witkowski; Teresa Liu-Ambrose; Laura Elizabeth Middleton; Quincy J. Almeida; Louis Bherer; Andrew Lim; Mark Speechley; Nellie Kamkar; Manuel Montero Odasso

doi:10.1136/bmjopen-2021-059988

Protocol for SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home): feasibility of a home-based double-blind randomised controlled trial to improve gait and cognition in individuals at risk for dementia

Chris McGibbon, Pam Jarrett, Grant Handrigan, Danielle Bouchard, Carole C.C. Tranchant, Andrew M. Sexton, Linda Yetman, Bryn Robinson, Stephanie Crapoulet, Ludivine Chamard-Witkowski, Teresa Liu-Ambrose, Laura Elizabeth Middleton, Quincy J. Almeida, Louis Bherer, Andrew Lim, Mark Speechley, Nellie Kamkar, Manuel Montero Odasso

Medicine

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Introduction Physical exercise and cognitive training have the potential to enhance cognitive function and mobility in older adults at risk of Alzheimer's disease and related dementia (ADRD), but little is known about the feasibility of delivering multidomain interventions in home settings of older adults at risk of ADRD. This study aims to assess the feasibility of home-based delivery of exercise and cognitive interventions, and to evaluate the relationship between participants' intervention preferences and their subsequent adherence. Secondary objectives include the effect of the interventions on ADRD risk factors, including frailty, mobility, sleep, diet and psychological health. Methods and analysis The SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home) feasibility trial is a randomised control trial that follows a 2×2 factorial design, with a 16-week home-based intervention programme (3 sessions per week) of physical exercises and cognitive training. Participants will be randomised in blocks of four to one of the following four arms: (1) combined exercise (aerobic and resistance)+cognitive training (NEUROPEAK); (2) combined exercise+control cognitive training (web searching); (3) control exercise (balance and toning)+cognitive training; and (4) control exercise+control cognitive training. SYNERGIC@Home will be implemented through video conferencing. Baseline and post-intervention assessments at 4-month and 10-month follow-up will include measures of cognition, frailty, mobility, sleep, diet and psychological health. Primary feasibility outcome is adherence to the interventions. Primary analytic outcome is the relationship between pre-allocation preference for a given intervention and subsequent adherence to the allocated intervention. A series of secondary analytic outcomes examining the potential effect of the individual and combined interventions on cognitive, mobility and general well-being will be measured at baseline and follow-up. Ethics and dissemination Ethics approval was granted by the relevant research ethics boards. Findings of the study will be presented to stakeholders and published in peer-reviewed journals and at provincial, national and international conferences. Trial registration number NCT04997681, Pre-results.

Original language	English
Article number	e059988
Journal	BMJ Open
Volume	12
Issue number	3
DOIs	https://doi.org/10.1136/bmjopen-2021-059988
Publication status	Published - Mar 31 2022

Bibliographical note

Funding Information:
Funding This work is supported by the Healthy Seniors Pilot Project (funding

Funding Information:
We acknowledge the significant contributions of Canadian Consortium on Neurodegeneration in Aging CAN-THUMBS UP Group's co-principal investigators: Howard Chertkow, Sylvie Belleville, Howard Feldman, Manuel Montero-Odasso, Haakon Nygaard; and Steering Committee members: Danielle Alcock, Nicole Anderson, Sarah Banks, Paul Brewster, Senny Chan, Marc Cuesta, Samir Das, Carol Evans, Guylaine Ferland, Tati Herold, Scott Hofer, Inbal Itzhak, Diane Jacobs, Pam Jarrett, Nellie Kamkar, Andrew Lim, Jody-Lynn Lupo, Lisa Madlensky, Chris McGibbon, Karen Messer, Zia Mohades, Carolyn Revta, Julie Robillard, Penny Slack, Eric Smith, Mark Speechley, Jennifer Walker and Jingjing Zou. This programme was made possible by the participation of the Citizen Advisory Group, research students, support staff and other special groups. This work is supported by the Healthy Seniors Pilot Project (funding application C0042, January 2020 ? October 2022), funded through the Government of New Brunswick and the Public Health Agency of Canada.The Canadian Consortium on Neurodegeneration in Aging is supported by a grant from the Canadian Institutes of Health Research with additional funding from several partners. A substantial component of this funding for the CAN-THUMBS UP program derives from the Alzheimer?s Society of Canada CCNA partnership.

Publisher Copyright:
© 2022 BMJ Publishing Group. All rights reserved.

ASJC Scopus Subject Areas

General Medicine

PubMed: MeSH publication types

Clinical Trial Protocol
Journal Article
Research Support, Non-U.S. Gov't

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McGibbon, C., Jarrett, P., Handrigan, G., Bouchard, D., Tranchant, C. C. C., Sexton, A. M., Yetman, L., Robinson, B., Crapoulet, S., Chamard-Witkowski, L., Liu-Ambrose, T., Middleton, L. E., Almeida, Q. J., Bherer, L., Lim, A., Speechley, M., Kamkar, N., & Montero Odasso, M. (2022). Protocol for SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home): feasibility of a home-based double-blind randomised controlled trial to improve gait and cognition in individuals at risk for dementia. BMJ Open, 12(3), Article e059988. https://doi.org/10.1136/bmjopen-2021-059988

Protocol for SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home): feasibility of a home-based double-blind randomised controlled trial to improve gait and cognition in individuals at risk for dementia. / McGibbon, Chris; Jarrett, Pam; Handrigan, Grant et al.
In: BMJ Open, Vol. 12, No. 3, e059988, 31.03.2022.

Research output: Contribution to journal › Article › peer-review

McGibbon, C, Jarrett, P, Handrigan, G, Bouchard, D, Tranchant, CCC, Sexton, AM, Yetman, L, Robinson, B, Crapoulet, S, Chamard-Witkowski, L, Liu-Ambrose, T, Middleton, LE, Almeida, QJ, Bherer, L, Lim, A, Speechley, M, Kamkar, N & Montero Odasso, M 2022, 'Protocol for SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home): feasibility of a home-based double-blind randomised controlled trial to improve gait and cognition in individuals at risk for dementia', BMJ Open, vol. 12, no. 3, e059988. https://doi.org/10.1136/bmjopen-2021-059988

McGibbon C, Jarrett P, Handrigan G, Bouchard D, Tranchant CCC, Sexton AM et al. Protocol for SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home): feasibility of a home-based double-blind randomised controlled trial to improve gait and cognition in individuals at risk for dementia. BMJ Open. 2022 Mar 31;12(3):e059988. doi: 10.1136/bmjopen-2021-059988

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title = "Protocol for SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home): feasibility of a home-based double-blind randomised controlled trial to improve gait and cognition in individuals at risk for dementia",

abstract = "Introduction Physical exercise and cognitive training have the potential to enhance cognitive function and mobility in older adults at risk of Alzheimer's disease and related dementia (ADRD), but little is known about the feasibility of delivering multidomain interventions in home settings of older adults at risk of ADRD. This study aims to assess the feasibility of home-based delivery of exercise and cognitive interventions, and to evaluate the relationship between participants' intervention preferences and their subsequent adherence. Secondary objectives include the effect of the interventions on ADRD risk factors, including frailty, mobility, sleep, diet and psychological health. Methods and analysis The SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home) feasibility trial is a randomised control trial that follows a 2×2 factorial design, with a 16-week home-based intervention programme (3 sessions per week) of physical exercises and cognitive training. Participants will be randomised in blocks of four to one of the following four arms: (1) combined exercise (aerobic and resistance)+cognitive training (NEUROPEAK); (2) combined exercise+control cognitive training (web searching); (3) control exercise (balance and toning)+cognitive training; and (4) control exercise+control cognitive training. SYNERGIC@Home will be implemented through video conferencing. Baseline and post-intervention assessments at 4-month and 10-month follow-up will include measures of cognition, frailty, mobility, sleep, diet and psychological health. Primary feasibility outcome is adherence to the interventions. Primary analytic outcome is the relationship between pre-allocation preference for a given intervention and subsequent adherence to the allocated intervention. A series of secondary analytic outcomes examining the potential effect of the individual and combined interventions on cognitive, mobility and general well-being will be measured at baseline and follow-up. Ethics and dissemination Ethics approval was granted by the relevant research ethics boards. Findings of the study will be presented to stakeholders and published in peer-reviewed journals and at provincial, national and international conferences. Trial registration number NCT04997681, Pre-results. ",

author = "Chris McGibbon and Pam Jarrett and Grant Handrigan and Danielle Bouchard and Tranchant, {Carole C.C.} and Sexton, {Andrew M.} and Linda Yetman and Bryn Robinson and Stephanie Crapoulet and Ludivine Chamard-Witkowski and Teresa Liu-Ambrose and Middleton, {Laura Elizabeth} and Almeida, {Quincy J.} and Louis Bherer and Andrew Lim and Mark Speechley and Nellie Kamkar and {Montero Odasso}, Manuel",

note = "Funding Information: Funding This work is supported by the Healthy Seniors Pilot Project (funding Funding Information: We acknowledge the significant contributions of Canadian Consortium on Neurodegeneration in Aging CAN-THUMBS UP Group's co-principal investigators: Howard Chertkow, Sylvie Belleville, Howard Feldman, Manuel Montero-Odasso, Haakon Nygaard; and Steering Committee members: Danielle Alcock, Nicole Anderson, Sarah Banks, Paul Brewster, Senny Chan, Marc Cuesta, Samir Das, Carol Evans, Guylaine Ferland, Tati Herold, Scott Hofer, Inbal Itzhak, Diane Jacobs, Pam Jarrett, Nellie Kamkar, Andrew Lim, Jody-Lynn Lupo, Lisa Madlensky, Chris McGibbon, Karen Messer, Zia Mohades, Carolyn Revta, Julie Robillard, Penny Slack, Eric Smith, Mark Speechley, Jennifer Walker and Jingjing Zou. This programme was made possible by the participation of the Citizen Advisory Group, research students, support staff and other special groups. This work is supported by the Healthy Seniors Pilot Project (funding application C0042, January 2020 ? October 2022), funded through the Government of New Brunswick and the Public Health Agency of Canada.The Canadian Consortium on Neurodegeneration in Aging is supported by a grant from the Canadian Institutes of Health Research with additional funding from several partners. A substantial component of this funding for the CAN-THUMBS UP program derives from the Alzheimer?s Society of Canada CCNA partnership. Publisher Copyright: {\textcopyright} 2022 BMJ Publishing Group. All rights reserved.",

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doi = "10.1136/bmjopen-2021-059988",

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T1 - Protocol for SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home)

T2 - feasibility of a home-based double-blind randomised controlled trial to improve gait and cognition in individuals at risk for dementia

AU - McGibbon, Chris

AU - Jarrett, Pam

AU - Handrigan, Grant

AU - Bouchard, Danielle

AU - Tranchant, Carole C.C.

AU - Sexton, Andrew M.

AU - Yetman, Linda

AU - Robinson, Bryn

AU - Crapoulet, Stephanie

AU - Chamard-Witkowski, Ludivine

AU - Liu-Ambrose, Teresa

AU - Middleton, Laura Elizabeth

AU - Almeida, Quincy J.

AU - Bherer, Louis

AU - Lim, Andrew

AU - Speechley, Mark

AU - Kamkar, Nellie

AU - Montero Odasso, Manuel

N1 - Funding Information: Funding This work is supported by the Healthy Seniors Pilot Project (funding Funding Information: We acknowledge the significant contributions of Canadian Consortium on Neurodegeneration in Aging CAN-THUMBS UP Group's co-principal investigators: Howard Chertkow, Sylvie Belleville, Howard Feldman, Manuel Montero-Odasso, Haakon Nygaard; and Steering Committee members: Danielle Alcock, Nicole Anderson, Sarah Banks, Paul Brewster, Senny Chan, Marc Cuesta, Samir Das, Carol Evans, Guylaine Ferland, Tati Herold, Scott Hofer, Inbal Itzhak, Diane Jacobs, Pam Jarrett, Nellie Kamkar, Andrew Lim, Jody-Lynn Lupo, Lisa Madlensky, Chris McGibbon, Karen Messer, Zia Mohades, Carolyn Revta, Julie Robillard, Penny Slack, Eric Smith, Mark Speechley, Jennifer Walker and Jingjing Zou. This programme was made possible by the participation of the Citizen Advisory Group, research students, support staff and other special groups. This work is supported by the Healthy Seniors Pilot Project (funding application C0042, January 2020 ? October 2022), funded through the Government of New Brunswick and the Public Health Agency of Canada.The Canadian Consortium on Neurodegeneration in Aging is supported by a grant from the Canadian Institutes of Health Research with additional funding from several partners. A substantial component of this funding for the CAN-THUMBS UP program derives from the Alzheimer?s Society of Canada CCNA partnership. Publisher Copyright: © 2022 BMJ Publishing Group. All rights reserved.

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N2 - Introduction Physical exercise and cognitive training have the potential to enhance cognitive function and mobility in older adults at risk of Alzheimer's disease and related dementia (ADRD), but little is known about the feasibility of delivering multidomain interventions in home settings of older adults at risk of ADRD. This study aims to assess the feasibility of home-based delivery of exercise and cognitive interventions, and to evaluate the relationship between participants' intervention preferences and their subsequent adherence. Secondary objectives include the effect of the interventions on ADRD risk factors, including frailty, mobility, sleep, diet and psychological health. Methods and analysis The SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home) feasibility trial is a randomised control trial that follows a 2×2 factorial design, with a 16-week home-based intervention programme (3 sessions per week) of physical exercises and cognitive training. Participants will be randomised in blocks of four to one of the following four arms: (1) combined exercise (aerobic and resistance)+cognitive training (NEUROPEAK); (2) combined exercise+control cognitive training (web searching); (3) control exercise (balance and toning)+cognitive training; and (4) control exercise+control cognitive training. SYNERGIC@Home will be implemented through video conferencing. Baseline and post-intervention assessments at 4-month and 10-month follow-up will include measures of cognition, frailty, mobility, sleep, diet and psychological health. Primary feasibility outcome is adherence to the interventions. Primary analytic outcome is the relationship between pre-allocation preference for a given intervention and subsequent adherence to the allocated intervention. A series of secondary analytic outcomes examining the potential effect of the individual and combined interventions on cognitive, mobility and general well-being will be measured at baseline and follow-up. Ethics and dissemination Ethics approval was granted by the relevant research ethics boards. Findings of the study will be presented to stakeholders and published in peer-reviewed journals and at provincial, national and international conferences. Trial registration number NCT04997681, Pre-results.

AB - Introduction Physical exercise and cognitive training have the potential to enhance cognitive function and mobility in older adults at risk of Alzheimer's disease and related dementia (ADRD), but little is known about the feasibility of delivering multidomain interventions in home settings of older adults at risk of ADRD. This study aims to assess the feasibility of home-based delivery of exercise and cognitive interventions, and to evaluate the relationship between participants' intervention preferences and their subsequent adherence. Secondary objectives include the effect of the interventions on ADRD risk factors, including frailty, mobility, sleep, diet and psychological health. Methods and analysis The SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home) feasibility trial is a randomised control trial that follows a 2×2 factorial design, with a 16-week home-based intervention programme (3 sessions per week) of physical exercises and cognitive training. Participants will be randomised in blocks of four to one of the following four arms: (1) combined exercise (aerobic and resistance)+cognitive training (NEUROPEAK); (2) combined exercise+control cognitive training (web searching); (3) control exercise (balance and toning)+cognitive training; and (4) control exercise+control cognitive training. SYNERGIC@Home will be implemented through video conferencing. Baseline and post-intervention assessments at 4-month and 10-month follow-up will include measures of cognition, frailty, mobility, sleep, diet and psychological health. Primary feasibility outcome is adherence to the interventions. Primary analytic outcome is the relationship between pre-allocation preference for a given intervention and subsequent adherence to the allocated intervention. A series of secondary analytic outcomes examining the potential effect of the individual and combined interventions on cognitive, mobility and general well-being will be measured at baseline and follow-up. Ethics and dissemination Ethics approval was granted by the relevant research ethics boards. Findings of the study will be presented to stakeholders and published in peer-reviewed journals and at provincial, national and international conferences. Trial registration number NCT04997681, Pre-results.

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Protocol for SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home): feasibility of a home-based double-blind randomised controlled trial to improve gait and cognition in individuals at risk for dementia

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Access to Document

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