Rationale and protocol for a randomized waitlist controlled trial of videoconference delivered cognitive behaviour therapy for insomnia (CBT-I) to improve perceived cognitive impairment (PCI) among cancer survivors

Sheila N. Garland, Josée Savard, Kathryn Dalton, Nyissa A. Walsh, Melanie Seal, Joshua Rash, Sondria Browne, Robin Urquhart, John Thoms, Veeresh Gadag, Kara Laing

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Perceived cognitive impairment (PCI) and sleep disturbances (such as insomnia) are commonly reported barriers preventing cancer survivors from resuming normal functioning. Cognitive-behaviour therapy for insomnia (CBT-I) is the treatment of choice for insomnia among cancer survivors. Literature suggests that treatment with CBT-I may lead to an improvement in PCI, but this needs to be tested in a sample of patients with PCI at study entry with cognitive impairments as the primary study outcome. Here we describe the design of a clinical trial to evaluate the efficacy of videoconference-delivered CBT-I for the improvement of PCI among cancer survivors. This project is a randomized waitlist-controlled trial with a recruitment target of 124 adult cancer survivors (solid tumors and hematological malignancies) who have completed primary treatment at least 6 months prior, report PCI and meet criteria for insomnia disorder. Participants will complete assessments at baseline, 4 weeks (mid-treatment), 8 weeks (post treatment), and 3 and 6 months post-treatment. The primary outcome is the Functional Assessment of Cancer Therapy – Cognitive Function (FACT-Cog). Treatment of PCI in cancer patients is a priority for clinicians, researchers, and patients. This research will increase our understanding of the mechanisms of cognitive impairment associated with cancer, and potentially expand currently available treatment options.

Original languageEnglish
Article number106322
JournalContemporary Clinical Trials
Volume103
DOIs
Publication statusPublished - Apr 2021

Bibliographical note

Funding Information:
Research reported in this article was funded through a grant from Canadian Institutes of Health Research (CIHR) (grant number: PJT 162428 ) and the Beatrice Hunter Cancer Research Institute .

Publisher Copyright:
© 2021 Elsevier Inc.

ASJC Scopus Subject Areas

  • Pharmacology (medical)

PubMed: MeSH publication types

  • Clinical Trial Protocol
  • Journal Article
  • Research Support, Non-U.S. Gov't

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