Recurrent Optic Disc Hemorrhage and Its Association with Visual Field Deterioration in Glaucoma

Dong An; Philip House; Christopher Barry; Andrew Turpin; Allison M. McKendrick; Balwantray C. Chauhan; Siobhan Manners; Stuart Graham; Dao Yi Yu; William H. Morgan

doi:10.1016/j.ogla.2020.06.004

Recurrent Optic Disc Hemorrhage and Its Association with Visual Field Deterioration in Glaucoma

Dong An, Philip House, Christopher Barry, Andrew Turpin, Allison M. McKendrick, Balwantray C. Chauhan, Siobhan Manners, Stuart Graham, Dao Yi Yu, William H. Morgan

Medicine

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Purpose: To investigate the association among optic disc hemorrhage (ODH) recurrence, location, and visual field (VF) progression. Design: Prospective, observational study. Participants: Patients with bilateral glaucoma or unilateral glaucoma with a fellow glaucoma suspect eye were enrolled. Methods: Patients received optic disc photography every 3 months and VF testing every 4 months. The disc was partitioned into 8 sectors to match 8 visual field (VF) sectors. The frequency of ODH in each sector was quantified over an average of 64 months. Global VF progression rate was calculated using linear regression on mean deviation. Sectoral progression rate was calculated using linear regression on the sensitivity at each VF location over time and then selecting the largest and second largest significant (P < 0.05) negative slope within that sector. The association between ODH and VF progression rate globally and within a sector was calculated using linear mixed modeling. Main Outcome Measures: Global and sectoral VF progression, ODH frequency, and ODH recurrence (globally and sectoral) and its association with VF progression rate. Results: A total of 151 eyes from 77 patients completed the study with mean follow-up of 64 months, 20 disc photographs, and 16 VF tests. With global VF analysis, eyes with ODH in 2 different sectors of the disc had worse progression rate than eyes with ODH in 1 sector (P = 0.012) and eyes with no ODH (P < 0.001). Regarding the largest sectoral VF progression, sectors with 1 ODH had a faster VF progression rate than those with no ODH (P < 0.017) and progressed at a similar rate to those with 2 to 8 ODH (P = 0.592). Sectors with >8 ODH had faster VF progression than all other groups (all P < 0.001). Conclusions: High-frequency ODH within optic disc sectors, equivalent to detecting ODH in 45% of 3 monthly eye examination visits, was associated with significantly worse VF progression than sectors with moderate or only 1 observed ODH. In addition, ODH occurring in different sectors in the same eye was more strongly associated with greater global VF progression compared with those occurring within the same sector.

Original language	English
Pages (from-to)	443-452
Number of pages	10
Journal	Ophthalmology. Glaucoma
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/j.ogla.2020.06.004
Publication status	Published - Nov 1 2020

Bibliographical note

Funding Information:
Financial Disclosure(s): The author(s) have made the following disclosure(s): B.C.C.: Research support – CenterVue, Heidelberg Engineering, TopconA.M.M.: Research support – CenterVue SpA, Heidelberg Engineering GmBH, Haag-Streit AGAT, CenterVue SpA, Heidelberg Engineering GmBH, Haag-Streit.Supported by the National Health and Medical Research Council of Australia. National Health and Medical Research Council (NHMRC) Grant Reference Number APP1020367WHM, NHMRC Project Grant 102367WHM, and NHMRC Development Grant 107310WHM. The funder had no role in study design, data collection, data analysis, decision to publish, or preparation of the manuscript.HUMAN SUBJECTS: Human subjects were included in this study. Ethics approval was granted by the University of Western Australia Human Ethics Committee. All research adhered to the tenets of the Declaration of Helsinki. All participants provided informed consent. Obtained funding: Chauhan, McKendrick; Study was performed as part of the authors' regular employment duties. No additional funding was provided.

Publisher Copyright:
© 2020 American Academy of Ophthalmology

ASJC Scopus Subject Areas

Ophthalmology
General Medicine

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10.1016/j.ogla.2020.06.004

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title = "Recurrent Optic Disc Hemorrhage and Its Association with Visual Field Deterioration in Glaucoma",

abstract = "Purpose: To investigate the association among optic disc hemorrhage (ODH) recurrence, location, and visual field (VF) progression. Design: Prospective, observational study. Participants: Patients with bilateral glaucoma or unilateral glaucoma with a fellow glaucoma suspect eye were enrolled. Methods: Patients received optic disc photography every 3 months and VF testing every 4 months. The disc was partitioned into 8 sectors to match 8 visual field (VF) sectors. The frequency of ODH in each sector was quantified over an average of 64 months. Global VF progression rate was calculated using linear regression on mean deviation. Sectoral progression rate was calculated using linear regression on the sensitivity at each VF location over time and then selecting the largest and second largest significant (P < 0.05) negative slope within that sector. The association between ODH and VF progression rate globally and within a sector was calculated using linear mixed modeling. Main Outcome Measures: Global and sectoral VF progression, ODH frequency, and ODH recurrence (globally and sectoral) and its association with VF progression rate. Results: A total of 151 eyes from 77 patients completed the study with mean follow-up of 64 months, 20 disc photographs, and 16 VF tests. With global VF analysis, eyes with ODH in 2 different sectors of the disc had worse progression rate than eyes with ODH in 1 sector (P = 0.012) and eyes with no ODH (P < 0.001). Regarding the largest sectoral VF progression, sectors with 1 ODH had a faster VF progression rate than those with no ODH (P < 0.017) and progressed at a similar rate to those with 2 to 8 ODH (P = 0.592). Sectors with >8 ODH had faster VF progression than all other groups (all P < 0.001). Conclusions: High-frequency ODH within optic disc sectors, equivalent to detecting ODH in 45% of 3 monthly eye examination visits, was associated with significantly worse VF progression than sectors with moderate or only 1 observed ODH. In addition, ODH occurring in different sectors in the same eye was more strongly associated with greater global VF progression compared with those occurring within the same sector.",

author = "Dong An and Philip House and Christopher Barry and Andrew Turpin and McKendrick, {Allison M.} and Chauhan, {Balwantray C.} and Siobhan Manners and Stuart Graham and Yu, {Dao Yi} and Morgan, {William H.}",

note = "Funding Information: Financial Disclosure(s): The author(s) have made the following disclosure(s): B.C.C.: Research support – CenterVue, Heidelberg Engineering, TopconA.M.M.: Research support – CenterVue SpA, Heidelberg Engineering GmBH, Haag-Streit AGAT, CenterVue SpA, Heidelberg Engineering GmBH, Haag-Streit.Supported by the National Health and Medical Research Council of Australia. National Health and Medical Research Council (NHMRC) Grant Reference Number APP1020367WHM, NHMRC Project Grant 102367WHM, and NHMRC Development Grant 107310WHM. The funder had no role in study design, data collection, data analysis, decision to publish, or preparation of the manuscript.HUMAN SUBJECTS: Human subjects were included in this study. Ethics approval was granted by the University of Western Australia Human Ethics Committee. All research adhered to the tenets of the Declaration of Helsinki. All participants provided informed consent. Obtained funding: Chauhan, McKendrick; Study was performed as part of the authors' regular employment duties. No additional funding was provided. Publisher Copyright: {\textcopyright} 2020 American Academy of Ophthalmology",

year = "2020",

month = nov,

day = "1",

doi = "10.1016/j.ogla.2020.06.004",

language = "English",

volume = "3",

pages = "443--452",

journal = "Ophthalmology. Glaucoma",

issn = "2589-4234",

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number = "6",

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TY - JOUR

T1 - Recurrent Optic Disc Hemorrhage and Its Association with Visual Field Deterioration in Glaucoma

AU - An, Dong

AU - House, Philip

AU - Barry, Christopher

AU - Turpin, Andrew

AU - McKendrick, Allison M.

AU - Chauhan, Balwantray C.

AU - Manners, Siobhan

AU - Graham, Stuart

AU - Yu, Dao Yi

AU - Morgan, William H.

N1 - Funding Information: Financial Disclosure(s): The author(s) have made the following disclosure(s): B.C.C.: Research support – CenterVue, Heidelberg Engineering, TopconA.M.M.: Research support – CenterVue SpA, Heidelberg Engineering GmBH, Haag-Streit AGAT, CenterVue SpA, Heidelberg Engineering GmBH, Haag-Streit.Supported by the National Health and Medical Research Council of Australia. National Health and Medical Research Council (NHMRC) Grant Reference Number APP1020367WHM, NHMRC Project Grant 102367WHM, and NHMRC Development Grant 107310WHM. The funder had no role in study design, data collection, data analysis, decision to publish, or preparation of the manuscript.HUMAN SUBJECTS: Human subjects were included in this study. Ethics approval was granted by the University of Western Australia Human Ethics Committee. All research adhered to the tenets of the Declaration of Helsinki. All participants provided informed consent. Obtained funding: Chauhan, McKendrick; Study was performed as part of the authors' regular employment duties. No additional funding was provided. Publisher Copyright: © 2020 American Academy of Ophthalmology

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Purpose: To investigate the association among optic disc hemorrhage (ODH) recurrence, location, and visual field (VF) progression. Design: Prospective, observational study. Participants: Patients with bilateral glaucoma or unilateral glaucoma with a fellow glaucoma suspect eye were enrolled. Methods: Patients received optic disc photography every 3 months and VF testing every 4 months. The disc was partitioned into 8 sectors to match 8 visual field (VF) sectors. The frequency of ODH in each sector was quantified over an average of 64 months. Global VF progression rate was calculated using linear regression on mean deviation. Sectoral progression rate was calculated using linear regression on the sensitivity at each VF location over time and then selecting the largest and second largest significant (P < 0.05) negative slope within that sector. The association between ODH and VF progression rate globally and within a sector was calculated using linear mixed modeling. Main Outcome Measures: Global and sectoral VF progression, ODH frequency, and ODH recurrence (globally and sectoral) and its association with VF progression rate. Results: A total of 151 eyes from 77 patients completed the study with mean follow-up of 64 months, 20 disc photographs, and 16 VF tests. With global VF analysis, eyes with ODH in 2 different sectors of the disc had worse progression rate than eyes with ODH in 1 sector (P = 0.012) and eyes with no ODH (P < 0.001). Regarding the largest sectoral VF progression, sectors with 1 ODH had a faster VF progression rate than those with no ODH (P < 0.017) and progressed at a similar rate to those with 2 to 8 ODH (P = 0.592). Sectors with >8 ODH had faster VF progression than all other groups (all P < 0.001). Conclusions: High-frequency ODH within optic disc sectors, equivalent to detecting ODH in 45% of 3 monthly eye examination visits, was associated with significantly worse VF progression than sectors with moderate or only 1 observed ODH. In addition, ODH occurring in different sectors in the same eye was more strongly associated with greater global VF progression compared with those occurring within the same sector.

AB - Purpose: To investigate the association among optic disc hemorrhage (ODH) recurrence, location, and visual field (VF) progression. Design: Prospective, observational study. Participants: Patients with bilateral glaucoma or unilateral glaucoma with a fellow glaucoma suspect eye were enrolled. Methods: Patients received optic disc photography every 3 months and VF testing every 4 months. The disc was partitioned into 8 sectors to match 8 visual field (VF) sectors. The frequency of ODH in each sector was quantified over an average of 64 months. Global VF progression rate was calculated using linear regression on mean deviation. Sectoral progression rate was calculated using linear regression on the sensitivity at each VF location over time and then selecting the largest and second largest significant (P < 0.05) negative slope within that sector. The association between ODH and VF progression rate globally and within a sector was calculated using linear mixed modeling. Main Outcome Measures: Global and sectoral VF progression, ODH frequency, and ODH recurrence (globally and sectoral) and its association with VF progression rate. Results: A total of 151 eyes from 77 patients completed the study with mean follow-up of 64 months, 20 disc photographs, and 16 VF tests. With global VF analysis, eyes with ODH in 2 different sectors of the disc had worse progression rate than eyes with ODH in 1 sector (P = 0.012) and eyes with no ODH (P < 0.001). Regarding the largest sectoral VF progression, sectors with 1 ODH had a faster VF progression rate than those with no ODH (P < 0.017) and progressed at a similar rate to those with 2 to 8 ODH (P = 0.592). Sectors with >8 ODH had faster VF progression than all other groups (all P < 0.001). Conclusions: High-frequency ODH within optic disc sectors, equivalent to detecting ODH in 45% of 3 monthly eye examination visits, was associated with significantly worse VF progression than sectors with moderate or only 1 observed ODH. In addition, ODH occurring in different sectors in the same eye was more strongly associated with greater global VF progression compared with those occurring within the same sector.

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Recurrent Optic Disc Hemorrhage and Its Association with Visual Field Deterioration in Glaucoma

Abstract

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