Regulation of Antimicrobial Pathways by Endogenous Heat Shock Proteins in Gastrointestinal Disorders

Emma Finlayson-Trick; Jessica Connors; Andrew Stadnyk; Johan Van Limbergen

doi:10.3390/gidisord1010005

Regulation of Antimicrobial Pathways by Endogenous Heat Shock Proteins in Gastrointestinal Disorders

Emma Finlayson-Trick, Jessica Connors, Andrew Stadnyk, Johan Van Limbergen

Medicine

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Heat shock proteins (HSPs) are essential mediators of cellular homeostasis by maintaining protein functionality and stability, and activating appropriate immune cells. HSP activity is influenced by a variety of factors including diet, microbial stimuli, environment and host immunity. The overexpression and down-regulation of HSPs is associated with various disease phenotypes, including the inflammatory bowel diseases (IBD) such as Crohn’s disease (CD). While the precise etiology of CD remains unclear, many of the putative triggers also influence HSP activity. The development of different CD phenotypes therefore may be a result of the disease-modifying behavior of the environmentally-regulated HSPs. Understanding the role of bacterial and endogenous HSPs in host homeostasis and disease will help elucidate the complex interplay of factors. Furthermore, discerning the function of HSPs in CD may lead to therapeutic developments that better reflect and respond to the gut environment.

Original language	English
Pages (from-to)	39-56
Number of pages	18
Journal	Gastrointestinal Disorders
Volume	1
Issue number	1
DOIs	https://doi.org/10.3390/gidisord1010005
Publication status	Published - Dec 2019

Bibliographical note

Funding Information:
E.F.-T. was supported by a NSERC Alexander Graham Bell Graduate Scholarship (Masters) and the DMRF Edward F Crease Memorial Graduate Studentship in Cancer Research from the Beatrice Hunter Cancer Research Training Program. J.V.L. was supported by a Canadian Institutes of Health Research (CIHR)-CAG-CCC New Investigator Award (2015–2018), a Canada Research Chair Tier 2 in Translational Microbiomics (2018-2023), a Canadian Foundation of Innovation John R. Evans Leadership fund (awards #35235 and #36764), a Nova Scotia Health Research Foundation (NSHRF) establishment award (2015–2017), an IWK Health Centre Research Associateship (for J.C.), a donation from the MacLeod family, an American Gastroenterology Association 2018-Pfizer Young Investigator Pilot Research Award in Inflammatory Bowel Disease, and by a CIHR-SPOR-Chronic Diseases grant (Inflammation, Microbiome, and Alimentation: Gastro-Intestinal and Neuropsychiatric Effects: the IMAGINE-SPOR chronic disease network).

Publisher Copyright:
© 2018 by the authors.

ASJC Scopus Subject Areas

Gastroenterology
Hepatology
Immunology and Microbiology (miscellaneous)
Oncology

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10.3390/gidisord1010005

Cite this

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abstract = "Heat shock proteins (HSPs) are essential mediators of cellular homeostasis by maintaining protein functionality and stability, and activating appropriate immune cells. HSP activity is influenced by a variety of factors including diet, microbial stimuli, environment and host immunity. The overexpression and down-regulation of HSPs is associated with various disease phenotypes, including the inflammatory bowel diseases (IBD) such as Crohn{\textquoteright}s disease (CD). While the precise etiology of CD remains unclear, many of the putative triggers also influence HSP activity. The development of different CD phenotypes therefore may be a result of the disease-modifying behavior of the environmentally-regulated HSPs. Understanding the role of bacterial and endogenous HSPs in host homeostasis and disease will help elucidate the complex interplay of factors. Furthermore, discerning the function of HSPs in CD may lead to therapeutic developments that better reflect and respond to the gut environment.",

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note = "Funding Information: E.F.-T. was supported by a NSERC Alexander Graham Bell Graduate Scholarship (Masters) and the DMRF Edward F Crease Memorial Graduate Studentship in Cancer Research from the Beatrice Hunter Cancer Research Training Program. J.V.L. was supported by a Canadian Institutes of Health Research (CIHR)-CAG-CCC New Investigator Award (2015–2018), a Canada Research Chair Tier 2 in Translational Microbiomics (2018-2023), a Canadian Foundation of Innovation John R. Evans Leadership fund (awards #35235 and #36764), a Nova Scotia Health Research Foundation (NSHRF) establishment award (2015–2017), an IWK Health Centre Research Associateship (for J.C.), a donation from the MacLeod family, an American Gastroenterology Association 2018-Pfizer Young Investigator Pilot Research Award in Inflammatory Bowel Disease, and by a CIHR-SPOR-Chronic Diseases grant (Inflammation, Microbiome, and Alimentation: Gastro-Intestinal and Neuropsychiatric Effects: the IMAGINE-SPOR chronic disease network). Publisher Copyright: {\textcopyright} 2018 by the authors.",

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Regulation of Antimicrobial Pathways by Endogenous Heat Shock Proteins in Gastrointestinal Disorders

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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