TY - CHAP
T1 - Regulation of permeability across the blood-brain barrier
AU - Easton, Alexander S.
PY - 2013
Y1 - 2013
N2 - The blood-brain barrier refers to the very low permeability across microvessels in the Central Nervous System (CNS), created by the interaction between vascular endothelial cells and surrounding cells of the neurovascular unit. Permeability can be modulated (increased and decreased) by a variety of factors including inflammatory mediators, inflammatory cells such as neutrophils and through alterations in the phenotype of blood vessels during angiogenesis and apoptosis. In this chapter, some of these factors are discussed as well as the challenge of treating harmful increases in permeability that result in brain swelling (vasogenic cerebral edema).
AB - The blood-brain barrier refers to the very low permeability across microvessels in the Central Nervous System (CNS), created by the interaction between vascular endothelial cells and surrounding cells of the neurovascular unit. Permeability can be modulated (increased and decreased) by a variety of factors including inflammatory mediators, inflammatory cells such as neutrophils and through alterations in the phenotype of blood vessels during angiogenesis and apoptosis. In this chapter, some of these factors are discussed as well as the challenge of treating harmful increases in permeability that result in brain swelling (vasogenic cerebral edema).
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U2 - 10.1007/978-1-4614-4711-5_1
DO - 10.1007/978-1-4614-4711-5_1
M3 - Chapter
C2 - 23397617
AN - SCOPUS:84934442331
SN - 9781461447108
T3 - Advances in Experimental Medicine and Biology
SP - 1
EP - 19
BT - Biology and Regulation of Blood-Tissue Barriers
PB - Springer New York LLC
ER -