Release of endogenous ATP during sympathetic nerve stimulation

M. J. Lew, T. D. White

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)

Abstract

Vas deferens from guinea‐pig was stimulated with a suction electrode and both contractions and release of endogenous ATP monitored Release of ATP was tetrodotoxin‐sensitive and increased when the number of stimuli was increased. Release of ATP was not due to contraction of the muscle and persisted following block of contractions with prazosin and α,β‐methylene ATP. These results indicate that stimulation of the sympathetic nerves in the vas deferens releases endogenous ATP presynaptically, supporting a cotransmitter function for ATP with noradrenaline. 1987 British Pharmacological Society

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalBritish Journal of Pharmacology
Volume92
Issue number2
DOIs
Publication statusPublished - Oct 1987
Externally publishedYes

ASJC Scopus Subject Areas

  • Pharmacology

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Lew, M. J., & White, T. D. (1987). Release of endogenous ATP during sympathetic nerve stimulation. British Journal of Pharmacology, 92(2), 349-355. https://doi.org/10.1111/j.1476-5381.1987.tb11330.x