Retrograde amnesia in dementia: Comparison of HIV-associated dementia, Alzheimer's disease, and Huntington's disease

Joseph R. Sadek; Desirée A. White; Kirsten I. Taylor; Jane S. Paulsen; Shannon A. Johnson; David P. Salmon; Jody H. DeLaPena; Robert K. Heaton; Igor Grant; J. Hampton Atkinson; J. Allen McCutchan; Thomas D. Marcotte; Mark R. Wallace; Ronald J. Ellis; Scott Letendre; Rachel Schrier; Mariana Cherner; Steven Paul Woods; Terry Jernigan; John Hesselink; Eliezer Masliah; Daniel R. Masys; Michelle Frybarger; Ian Abramson; Deborah Lazzaretto

doi:10.1037/0894-4105.18.4.692

Retrograde amnesia in dementia: Comparison of HIV-associated dementia, Alzheimer's disease, and Huntington's disease

Joseph R. Sadek, Desirée A. White, Kirsten I. Taylor, Jane S. Paulsen, Shannon A. Johnson, David P. Salmon, Jody H. DeLaPena, Robert K. Heaton, Igor Grant, J. Hampton Atkinson, J. Allen McCutchan, Thomas D. Marcotte, Mark R. Wallace, Ronald J. Ellis, Scott Letendre, Rachel Schrier, Mariana Cherner, Steven Paul Woods, Terry Jernigan, John HesselinkEliezer Masliah, Daniel R. Masys, Michelle Frybarger, Ian Abramson, Deborah Lazzaretto

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Remote memory was assessed in persons with HIV-associated dementia (HIV-D), probable Alzheimer's disease (AD), and Huntington's disease (HD) and in healthy controls. The clinical groups were similar in overall dementia severity. Each clinical group exhibited impairments on remote memory tests relative to controls; however, temporally graded memory loss with selective preservation of older information was observed in the AD group but not the HD or HIV-D group. Analysis of cued retrieval indicated a preferential cuing benefit for the HIV-D and HD groups relative to the AD group. The similar pattern of remote memory performance demonstrated by the HIV-D and HD groups is a novel finding and suggests a subcortically mediated retrograde amnesia in HIV-D. The temporally graded pattern and the abnormal cued retrieval performance in the AD group are consistent with a consolidation deficit associated with extrahippocampal (cortical) and hippocampal damage.

Original language	English
Pages (from-to)	692-699
Number of pages	8
Journal	Neuropsychology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1037/0894-4105.18.4.692
Publication status	Published - Oct 2004
Externally published	Yes

ASJC Scopus Subject Areas

Neuropsychology and Physiological Psychology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1037/0894-4105.18.4.692

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Sadek, J. R., White, D. A., Taylor, K. I., Paulsen, J. S., Johnson, S. A., Salmon, D. P., DeLaPena, J. H., Heaton, R. K., Grant, I., Atkinson, J. H., McCutchan, J. A., Marcotte, T. D., Wallace, M. R., Ellis, R. J., Letendre, S., Schrier, R., Cherner, M., Woods, S. P., Jernigan, T., ... Lazzaretto, D. (2004). Retrograde amnesia in dementia: Comparison of HIV-associated dementia, Alzheimer's disease, and Huntington's disease. Neuropsychology, 18(4), 692-699. https://doi.org/10.1037/0894-4105.18.4.692

Sadek, JR, White, DA, Taylor, KI, Paulsen, JS, Johnson, SA, Salmon, DP, DeLaPena, JH, Heaton, RK, Grant, I, Atkinson, JH, McCutchan, JA, Marcotte, TD, Wallace, MR, Ellis, RJ, Letendre, S, Schrier, R, Cherner, M, Woods, SP, Jernigan, T, Hesselink, J, Masliah, E, Masys, DR, Frybarger, M, Abramson, I & Lazzaretto, D 2004, 'Retrograde amnesia in dementia: Comparison of HIV-associated dementia, Alzheimer's disease, and Huntington's disease', Neuropsychology, vol. 18, no. 4, pp. 692-699. https://doi.org/10.1037/0894-4105.18.4.692

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abstract = "Remote memory was assessed in persons with HIV-associated dementia (HIV-D), probable Alzheimer's disease (AD), and Huntington's disease (HD) and in healthy controls. The clinical groups were similar in overall dementia severity. Each clinical group exhibited impairments on remote memory tests relative to controls; however, temporally graded memory loss with selective preservation of older information was observed in the AD group but not the HD or HIV-D group. Analysis of cued retrieval indicated a preferential cuing benefit for the HIV-D and HD groups relative to the AD group. The similar pattern of remote memory performance demonstrated by the HIV-D and HD groups is a novel finding and suggests a subcortically mediated retrograde amnesia in HIV-D. The temporally graded pattern and the abnormal cued retrieval performance in the AD group are consistent with a consolidation deficit associated with extrahippocampal (cortical) and hippocampal damage.",

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AU - Schrier, Rachel

AU - Cherner, Mariana

AU - Woods, Steven Paul

AU - Jernigan, Terry

AU - Hesselink, John

AU - Masliah, Eliezer

AU - Masys, Daniel R.

AU - Frybarger, Michelle

AU - Abramson, Ian

AU - Lazzaretto, Deborah

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AB - Remote memory was assessed in persons with HIV-associated dementia (HIV-D), probable Alzheimer's disease (AD), and Huntington's disease (HD) and in healthy controls. The clinical groups were similar in overall dementia severity. Each clinical group exhibited impairments on remote memory tests relative to controls; however, temporally graded memory loss with selective preservation of older information was observed in the AD group but not the HD or HIV-D group. Analysis of cued retrieval indicated a preferential cuing benefit for the HIV-D and HD groups relative to the AD group. The similar pattern of remote memory performance demonstrated by the HIV-D and HD groups is a novel finding and suggests a subcortically mediated retrograde amnesia in HIV-D. The temporally graded pattern and the abnormal cued retrieval performance in the AD group are consistent with a consolidation deficit associated with extrahippocampal (cortical) and hippocampal damage.

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Retrograde amnesia in dementia: Comparison of HIV-associated dementia, Alzheimer's disease, and Huntington's disease

Abstract

ASJC Scopus Subject Areas

UN SDGs

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