Risk factors for re-hospitalization following neonatal discharge of extremely preterm infants in Canada

Zakariya Bambala Puthattayil; Thuy Mai Luu; Marc Beltempo; Shannon Cross; Thevanisha Pillay; Marilyn Ballantyne; Anne Synnes; Prakesh Shah; Thierry Daboval; Thevanisha Pillay; Leonora Hendson; Amber Reichert; Jaya Bodani; Sibasis Daspal; Diane Moddemann; Chukwuma Nwaesei; Thierry Daboval; Sarah Mcknight; Kevin Coughlin; Linh Ly; Edmond Kelly; Saroj Saigal; Karen Thomas; Paige Church; Ermelinda Pelausa; M. Khairy; Thuy Mai Luu; Charlotte Demers; Alyssa Morin; Sylvie Bélanger; Roderick Canning; Luis Monterrosa; Hala Makary; Jehier Afifi; Phil Murphy; Charles Janeway

doi:10.1093/pch/pxz143

Risk factors for re-hospitalization following neonatal discharge of extremely preterm infants in Canada

Zakariya Bambala Puthattayil, Thuy Mai Luu, Marc Beltempo, Shannon Cross, Thevanisha Pillay, Marilyn Ballantyne, Anne Synnes, Prakesh Shah, Thierry Daboval, Thevanisha Pillay, Leonora Hendson, Amber Reichert, Jaya Bodani, Sibasis Daspal, Diane Moddemann, Chukwuma Nwaesei, Thierry Daboval, Sarah Mcknight, Kevin Coughlin, Linh LyEdmond Kelly, Saroj Saigal, Karen Thomas, Paige Church, Ermelinda Pelausa, M. Khairy, Thuy Mai Luu, Charlotte Demers, Alyssa Morin, Sylvie Bélanger, Roderick Canning, Luis Monterrosa, Hala Makary, Jehier Afifi, Phil Murphy, Charles Janeway

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Objective: Survivors of extremely preterm birth are at risk of re-hospitalization but risk factors in the Canadian population are unknown. Our objective is to identify neonatal, sociodemographic, and geographic characteristics that predict re-hospitalization in Canadian extremely preterm neonates. Methods: This is a retrospective analysis of a prospective observational cohort study that included preterm infants born 22 to 28 weeks' gestational age from April 1, 2009 to September 30, 2011 and seen at 18 to 24 months corrected gestational age in a Canadian Neonatal Follow-Up Network clinic. Characteristics of infants re-hospitalized versus not re-hospitalized are compared. The potential neonatal, sociodemographic, and geographic factors with significant association in the univariate analysis are included in a multivariate model. Results: From a total of 2,275 preterm infants born at 22 to 28 weeks gestation included, 838 (36.8%) were re-hospitalized at least once. There were significant disparities between Canadian provincial regions, ranging from 25.9% to 49.4%. In the multivariate logistic regression analysis, factors associated with an increased risk for re-hospitalization were region of residence, male sex, bronchopulmonary dysplasia, necrotizing enterocolitis, prolonged neonatal intensive care unit (NICU) stay, ethnicity, Indigenous ethnicity, and sibling(s) in the home. Conclusion: Various neonatal, sociodemographic, and geographic factors predict re-hospitalization of extremely preterm infants born in Canada. The risk factors of re-hospitalization provide insights to help health care leaders explore potential preventative approaches to improve child health and reduce health care system costs.

Original language	English
Pages (from-to)	E96-E104
Journal	Paediatrics and Child Health
Volume	26
Issue number	2
DOIs	https://doi.org/10.1093/pch/pxz143
Publication status	Published - Apr 1 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 The Author(s). Published by Oxford University Press on behalf of the Canadian Paediatric Society. All rights reserved.

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health

PubMed: MeSH publication types

Journal Article

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Puthattayil, Z. B., Luu, T. M., Beltempo, M., Cross, S., Pillay, T., Ballantyne, M., Synnes, A., Shah, P., Daboval, T., Pillay, T., Hendson, L., Reichert, A., Bodani, J., Daspal, S., Moddemann, D., Nwaesei, C., Daboval, T., Mcknight, S., Coughlin, K., ... Janeway, C. (2021). Risk factors for re-hospitalization following neonatal discharge of extremely preterm infants in Canada. Paediatrics and Child Health, 26(2), E96-E104. https://doi.org/10.1093/pch/pxz143

Puthattayil, ZB, Luu, TM, Beltempo, M, Cross, S, Pillay, T, Ballantyne, M, Synnes, A, Shah, P, Daboval, T, Pillay, T, Hendson, L, Reichert, A, Bodani, J, Daspal, S, Moddemann, D, Nwaesei, C, Daboval, T, Mcknight, S, Coughlin, K, Ly, L, Kelly, E, Saigal, S, Thomas, K, Church, P, Pelausa, E, Khairy, M, Luu, TM, Demers, C, Morin, A, Bélanger, S, Canning, R, Monterrosa, L, Makary, H, Afifi, J, Murphy, P & Janeway, C 2021, 'Risk factors for re-hospitalization following neonatal discharge of extremely preterm infants in Canada', Paediatrics and Child Health, vol. 26, no. 2, pp. E96-E104. https://doi.org/10.1093/pch/pxz143

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title = "Risk factors for re-hospitalization following neonatal discharge of extremely preterm infants in Canada",

abstract = "Objective: Survivors of extremely preterm birth are at risk of re-hospitalization but risk factors in the Canadian population are unknown. Our objective is to identify neonatal, sociodemographic, and geographic characteristics that predict re-hospitalization in Canadian extremely preterm neonates. Methods: This is a retrospective analysis of a prospective observational cohort study that included preterm infants born 22 to 28 weeks' gestational age from April 1, 2009 to September 30, 2011 and seen at 18 to 24 months corrected gestational age in a Canadian Neonatal Follow-Up Network clinic. Characteristics of infants re-hospitalized versus not re-hospitalized are compared. The potential neonatal, sociodemographic, and geographic factors with significant association in the univariate analysis are included in a multivariate model. Results: From a total of 2,275 preterm infants born at 22 to 28 weeks gestation included, 838 (36.8%) were re-hospitalized at least once. There were significant disparities between Canadian provincial regions, ranging from 25.9% to 49.4%. In the multivariate logistic regression analysis, factors associated with an increased risk for re-hospitalization were region of residence, male sex, bronchopulmonary dysplasia, necrotizing enterocolitis, prolonged neonatal intensive care unit (NICU) stay, ethnicity, Indigenous ethnicity, and sibling(s) in the home. Conclusion: Various neonatal, sociodemographic, and geographic factors predict re-hospitalization of extremely preterm infants born in Canada. The risk factors of re-hospitalization provide insights to help health care leaders explore potential preventative approaches to improve child health and reduce health care system costs. ",

author = "Puthattayil, {Zakariya Bambala} and Luu, {Thuy Mai} and Marc Beltempo and Shannon Cross and Thevanisha Pillay and Marilyn Ballantyne and Anne Synnes and Prakesh Shah and Thierry Daboval and Thevanisha Pillay and Leonora Hendson and Amber Reichert and Jaya Bodani and Sibasis Daspal and Diane Moddemann and Chukwuma Nwaesei and Thierry Daboval and Sarah Mcknight and Kevin Coughlin and Linh Ly and Edmond Kelly and Saroj Saigal and Karen Thomas and Paige Church and Ermelinda Pelausa and M. Khairy and Luu, {Thuy Mai} and Charlotte Demers and Alyssa Morin and Sylvie B{\'e}langer and Roderick Canning and Luis Monterrosa and Hala Makary and Jehier Afifi and Phil Murphy and Charles Janeway",

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T1 - Risk factors for re-hospitalization following neonatal discharge of extremely preterm infants in Canada

AU - Puthattayil, Zakariya Bambala

AU - Luu, Thuy Mai

AU - Beltempo, Marc

AU - Cross, Shannon

AU - Pillay, Thevanisha

AU - Ballantyne, Marilyn

AU - Synnes, Anne

AU - Shah, Prakesh

AU - Daboval, Thierry

AU - Pillay, Thevanisha

AU - Hendson, Leonora

AU - Reichert, Amber

AU - Bodani, Jaya

AU - Daspal, Sibasis

AU - Moddemann, Diane

AU - Nwaesei, Chukwuma

AU - Daboval, Thierry

AU - Mcknight, Sarah

AU - Coughlin, Kevin

AU - Ly, Linh

AU - Kelly, Edmond

AU - Saigal, Saroj

AU - Thomas, Karen

AU - Church, Paige

AU - Pelausa, Ermelinda

AU - Khairy, M.

AU - Luu, Thuy Mai

AU - Demers, Charlotte

AU - Morin, Alyssa

AU - Bélanger, Sylvie

AU - Canning, Roderick

AU - Monterrosa, Luis

AU - Makary, Hala

AU - Afifi, Jehier

AU - Murphy, Phil

AU - Janeway, Charles

PY - 2021/4/1

Y1 - 2021/4/1

N2 - Objective: Survivors of extremely preterm birth are at risk of re-hospitalization but risk factors in the Canadian population are unknown. Our objective is to identify neonatal, sociodemographic, and geographic characteristics that predict re-hospitalization in Canadian extremely preterm neonates. Methods: This is a retrospective analysis of a prospective observational cohort study that included preterm infants born 22 to 28 weeks' gestational age from April 1, 2009 to September 30, 2011 and seen at 18 to 24 months corrected gestational age in a Canadian Neonatal Follow-Up Network clinic. Characteristics of infants re-hospitalized versus not re-hospitalized are compared. The potential neonatal, sociodemographic, and geographic factors with significant association in the univariate analysis are included in a multivariate model. Results: From a total of 2,275 preterm infants born at 22 to 28 weeks gestation included, 838 (36.8%) were re-hospitalized at least once. There were significant disparities between Canadian provincial regions, ranging from 25.9% to 49.4%. In the multivariate logistic regression analysis, factors associated with an increased risk for re-hospitalization were region of residence, male sex, bronchopulmonary dysplasia, necrotizing enterocolitis, prolonged neonatal intensive care unit (NICU) stay, ethnicity, Indigenous ethnicity, and sibling(s) in the home. Conclusion: Various neonatal, sociodemographic, and geographic factors predict re-hospitalization of extremely preterm infants born in Canada. The risk factors of re-hospitalization provide insights to help health care leaders explore potential preventative approaches to improve child health and reduce health care system costs.

AB - Objective: Survivors of extremely preterm birth are at risk of re-hospitalization but risk factors in the Canadian population are unknown. Our objective is to identify neonatal, sociodemographic, and geographic characteristics that predict re-hospitalization in Canadian extremely preterm neonates. Methods: This is a retrospective analysis of a prospective observational cohort study that included preterm infants born 22 to 28 weeks' gestational age from April 1, 2009 to September 30, 2011 and seen at 18 to 24 months corrected gestational age in a Canadian Neonatal Follow-Up Network clinic. Characteristics of infants re-hospitalized versus not re-hospitalized are compared. The potential neonatal, sociodemographic, and geographic factors with significant association in the univariate analysis are included in a multivariate model. Results: From a total of 2,275 preterm infants born at 22 to 28 weeks gestation included, 838 (36.8%) were re-hospitalized at least once. There were significant disparities between Canadian provincial regions, ranging from 25.9% to 49.4%. In the multivariate logistic regression analysis, factors associated with an increased risk for re-hospitalization were region of residence, male sex, bronchopulmonary dysplasia, necrotizing enterocolitis, prolonged neonatal intensive care unit (NICU) stay, ethnicity, Indigenous ethnicity, and sibling(s) in the home. Conclusion: Various neonatal, sociodemographic, and geographic factors predict re-hospitalization of extremely preterm infants born in Canada. The risk factors of re-hospitalization provide insights to help health care leaders explore potential preventative approaches to improve child health and reduce health care system costs.

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Risk factors for re-hospitalization following neonatal discharge of extremely preterm infants in Canada

Abstract

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