Role of eicosanoids in experimental alcoholic liver disease

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Based on our previous observations that linoleic acid is an important dietary requirement for the development of liver injury in the intragastric feeding rat model for alcoholic liver disease, we postulated that the conversion of linoleic acid to arachidonic acid and various eicosanoids could be important in the pathogenesis of liver injury. We showed that liver nonparenchymal cell production of thromboxane B2 and leukotriene B4 was higher in rats fed corn oil and ethanol (liver injury model) than in animals fed saturated fat and ethanol (no liver injury). In contrast, prostaglandin E2 levels were lower in the former group. The best correlate of pathologic changes was the plasma level of thromboxane B2. The importance of thromboxanes in alcoholic liver injury is further suggested by the fact that inhibition of thromboxane production is accompanied by amelioration of liver injury.

Original languageEnglish
Pages (from-to)443-446
Number of pages4
JournalAlcohol
Volume10
Issue number6
DOIs
Publication statusPublished - 1993
Externally publishedYes

ASJC Scopus Subject Areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

PubMed: MeSH publication types

  • Journal Article
  • Review

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