RU38486 Prolongs survival in murine congenital polycystic kidney disease

Malcolm R. Ogborn; John F.S. Crocker; Susanna C. McCarthy

doi:10.1016/0022-4731(87)90412-2

RU38486 Prolongs survival in murine congenital polycystic kidney disease

Malcolm R. Ogborn, John F.S. Crocker, Susanna C. McCarthy

Medicine

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The cpk/cpk mutant mouse develops a lethal infantile polycystic kidney disease that is associated with disregulation of post natal glucocorticoid production. To establish if the observed endocrine abnormality is involved in the pathophysiology of polycystic kidney disease, blockade of glucocorticoid action during the immediate post-natal period was attempted. The steroid antagonist, RU38486, when administered from day 3 to day 12 of post-natal life, prolonged survival in affected animals. This finding supports a role for steroid hormones in the pathogenesis of this form of polycystic kidney disease.

Original language	English
Pages (from-to)	783-784
Number of pages	2
Journal	Journal of Steroid Biochemistry
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/0022-4731(87)90412-2
Publication status	Published - Dec 1987

Bibliographical note

Funding Information:
Acknowledgements-This work was supported by a grant from the Kidney Foundation of Canada. Dr Ogborn was in receipt of a Board of Governor’s Fellowship of the Izaak Walton Killam Hospital for Children at the time of the study. The assistance of Dr S. R. Blecher in breeding cpk mice and MS B. Landry in preparation of the manuscript is gratefully acknowledged.

ASJC Scopus Subject Areas

Biochemistry
Endocrinology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

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10.1016/0022-4731(87)90412-2

Cite this

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title = "RU38486 Prolongs survival in murine congenital polycystic kidney disease",

abstract = "The cpk/cpk mutant mouse develops a lethal infantile polycystic kidney disease that is associated with disregulation of post natal glucocorticoid production. To establish if the observed endocrine abnormality is involved in the pathophysiology of polycystic kidney disease, blockade of glucocorticoid action during the immediate post-natal period was attempted. The steroid antagonist, RU38486, when administered from day 3 to day 12 of post-natal life, prolonged survival in affected animals. This finding supports a role for steroid hormones in the pathogenesis of this form of polycystic kidney disease.",

author = "Ogborn, {Malcolm R.} and Crocker, {John F.S.} and McCarthy, {Susanna C.}",

note = "Funding Information: Acknowledgements-This work was supported by a grant from the Kidney Foundation of Canada. Dr Ogborn was in receipt of a Board of Governor{\textquoteright}s Fellowship of the Izaak Walton Killam Hospital for Children at the time of the study. The assistance of Dr S. R. Blecher in breeding cpk mice and MS B. Landry in preparation of the manuscript is gratefully acknowledged.",

year = "1987",

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doi = "10.1016/0022-4731(87)90412-2",

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AU - Ogborn, Malcolm R.

AU - Crocker, John F.S.

AU - McCarthy, Susanna C.

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N2 - The cpk/cpk mutant mouse develops a lethal infantile polycystic kidney disease that is associated with disregulation of post natal glucocorticoid production. To establish if the observed endocrine abnormality is involved in the pathophysiology of polycystic kidney disease, blockade of glucocorticoid action during the immediate post-natal period was attempted. The steroid antagonist, RU38486, when administered from day 3 to day 12 of post-natal life, prolonged survival in affected animals. This finding supports a role for steroid hormones in the pathogenesis of this form of polycystic kidney disease.

AB - The cpk/cpk mutant mouse develops a lethal infantile polycystic kidney disease that is associated with disregulation of post natal glucocorticoid production. To establish if the observed endocrine abnormality is involved in the pathophysiology of polycystic kidney disease, blockade of glucocorticoid action during the immediate post-natal period was attempted. The steroid antagonist, RU38486, when administered from day 3 to day 12 of post-natal life, prolonged survival in affected animals. This finding supports a role for steroid hormones in the pathogenesis of this form of polycystic kidney disease.

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RU38486 Prolongs survival in murine congenital polycystic kidney disease

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

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