TY - JOUR
T1 - Serum amyloid P component binding to shiga toxin 2 requires both A subunit and B pentamer
AU - Marcato, Paola
AU - Vander Helm, Kathleen
AU - Mulvey, George L.
AU - Armstrong, Glen D.
PY - 2003/10/1
Y1 - 2003/10/1
N2 - Solid-phase binding, competitive binding, and cytotoxicity neutralization assays indicate that the B pentamer and A subunit both contribute to human serum amyloid P (HuSAP) component binding to Stx2. A polyvalent globotriaosyl-ceramide receptor analog, Daisy, did not competitively inhibit HuSAP binding, implying that the two ligands bind to different Stx2 domains.
AB - Solid-phase binding, competitive binding, and cytotoxicity neutralization assays indicate that the B pentamer and A subunit both contribute to human serum amyloid P (HuSAP) component binding to Stx2. A polyvalent globotriaosyl-ceramide receptor analog, Daisy, did not competitively inhibit HuSAP binding, implying that the two ligands bind to different Stx2 domains.
UR - http://www.scopus.com/inward/record.url?scp=0141557580&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141557580&partnerID=8YFLogxK
U2 - 10.1128/IAI.71.10.6075-6078.2003
DO - 10.1128/IAI.71.10.6075-6078.2003
M3 - Article
C2 - 14500533
AN - SCOPUS:0141557580
SN - 0019-9567
VL - 71
SP - 6075
EP - 6078
JO - Infection and Immunity
JF - Infection and Immunity
IS - 10
ER -
