Abstract
1. Single-channel recording from visualised endplates in freshly dissociated muscles from postnatal and denervated rat muscle revealed the presence of a low conductance, fetal type of acetylcholine receptor. 2. Kinetic analysis showed a main component in the burst durations with a mean of 10.8±2.7 ms (n = 29). Receptors from female rats had an additional 27.3±5.5 ms (n = 5) kinetic component which was found in one-third of the 15 female endplates. 3. Recordings from male and female denervated muscles gave more homogeneous kinetics with single time constants of 7.2±1.3 and 7.4±1.3 ms, respectively. 4. It is concluded that the acetylcholine receptor channels present during early development are different from those of denervated muscle.
| Original language | English |
|---|---|
| Pages (from-to) | 175-180 |
| Number of pages | 6 |
| Journal | Journal of Physiology |
| Volume | 532 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Apr 1 2001 |
ASJC Scopus Subject Areas
- Physiology
PubMed: MeSH publication types
- Comparative Study
- Journal Article
- Research Support, Non-U.S. Gov't