Sleep in offspring of parents with mood disorders

Delainey L. Wescott; Jessica Morash-Conway; Alyson Zwicker; Jill Cumby; Rudolf Uher; Benjamin Rusak

doi:10.3389/fpsyt.2019.00225

Sleep in offspring of parents with mood disorders

Delainey L. Wescott, Jessica Morash-Conway, Alyson Zwicker, Jill Cumby, Rudolf Uher, Benjamin Rusak

Medicine

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Background: Sleep problems in childhood are an early predictor of mood disorders among individuals at high familial risk. However, the majority of the research has focused on sleep disturbances in already diagnosed individuals and has largely neglected investigating potential differences between weeknight and weekend sleep in high-risk offspring. This study examined sleep parameters in offspring of parents with major depressive disorder or bipolar disorder during both weeknights and weekends. Methods: We used actigraphy, sleep diaries, and questionnaires to measure several sleep characteristics in 73 offspring aged 4-19 years: 23 offspring of a parent with major depressive disorder, 22 offspring of a parent with bipolar disorder, and 28 control offspring. Results: Offspring of parents with major depressive disorder slept, on average, 26 min more than control offspring on weeknights (95% confidence interval, 3 to 49 min, p = 0.027). Offspring of parents with bipolar disorder slept, on average, 27 min more on weekends than on weeknights compared to controls, resulting in a significant family history × weekend interaction (95% confidence interval, 7 to 47 min, p = 0.008). Conclusions: Sleep patterns in children and adolescents were related to the psychiatric diagnosis of their parent(s). Future follow-up of these results may clarify the relations between early sleep differences and the risk of developing mood disorders in individuals at high familial risk.

Original language	English
Article number	225
Journal	Frontiers in Psychiatry
Volume	10
Issue number	APR
DOIs	https://doi.org/10.3389/fpsyt.2019.00225
Publication status	Published - 2019

Bibliographical note

Funding Information:
This project was supported by funding from the Dalhousie Psychiatry Research Fund, Lindsay Family Graduate Scholarship, Canada Research Chairs Program (award number 231397), the Canadian Institutes of Health Research (grant reference numbers 124976, 142738, and 148394), the Brain & Behavior Research Foundation (NARSAD) Independent Investigator Grant 24684, Nova Scotia Health Research Foundation (grants 275319, 1716, and 353892), the Dalhousie Medical Research Foundation, and the Natural Sciences and Engineering Research Council of Canada (grant RGPIN-305).

Publisher Copyright:
Copyright © 2019 Wescott, Morash-Conway, Zwicker, Cumby, Uher and Rusak. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

ASJC Scopus Subject Areas

Psychiatry and Mental health

PubMed: MeSH publication types

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fpsyt.2019.00225

Cite this

@article{155237743ee74e21aa21b629087546d0,

title = "Sleep in offspring of parents with mood disorders",

abstract = "Background: Sleep problems in childhood are an early predictor of mood disorders among individuals at high familial risk. However, the majority of the research has focused on sleep disturbances in already diagnosed individuals and has largely neglected investigating potential differences between weeknight and weekend sleep in high-risk offspring. This study examined sleep parameters in offspring of parents with major depressive disorder or bipolar disorder during both weeknights and weekends. Methods: We used actigraphy, sleep diaries, and questionnaires to measure several sleep characteristics in 73 offspring aged 4-19 years: 23 offspring of a parent with major depressive disorder, 22 offspring of a parent with bipolar disorder, and 28 control offspring. Results: Offspring of parents with major depressive disorder slept, on average, 26 min more than control offspring on weeknights (95% confidence interval, 3 to 49 min, p = 0.027). Offspring of parents with bipolar disorder slept, on average, 27 min more on weekends than on weeknights compared to controls, resulting in a significant family history × weekend interaction (95% confidence interval, 7 to 47 min, p = 0.008). Conclusions: Sleep patterns in children and adolescents were related to the psychiatric diagnosis of their parent(s). Future follow-up of these results may clarify the relations between early sleep differences and the risk of developing mood disorders in individuals at high familial risk.",

author = "Wescott, {Delainey L.} and Jessica Morash-Conway and Alyson Zwicker and Jill Cumby and Rudolf Uher and Benjamin Rusak",

note = "Funding Information: This project was supported by funding from the Dalhousie Psychiatry Research Fund, Lindsay Family Graduate Scholarship, Canada Research Chairs Program (award number 231397), the Canadian Institutes of Health Research (grant reference numbers 124976, 142738, and 148394), the Brain & Behavior Research Foundation (NARSAD) Independent Investigator Grant 24684, Nova Scotia Health Research Foundation (grants 275319, 1716, and 353892), the Dalhousie Medical Research Foundation, and the Natural Sciences and Engineering Research Council of Canada (grant RGPIN-305). Publisher Copyright: Copyright {\textcopyright} 2019 Wescott, Morash-Conway, Zwicker, Cumby, Uher and Rusak. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.",

year = "2019",

doi = "10.3389/fpsyt.2019.00225",

language = "English",

volume = "10",

journal = "Frontiers in Psychiatry",

issn = "1664-0640",

publisher = "Frontiers Research Foundation",

number = "APR",

}

TY - JOUR

T1 - Sleep in offspring of parents with mood disorders

AU - Wescott, Delainey L.

AU - Morash-Conway, Jessica

AU - Zwicker, Alyson

AU - Cumby, Jill

AU - Uher, Rudolf

AU - Rusak, Benjamin

N1 - Funding Information: This project was supported by funding from the Dalhousie Psychiatry Research Fund, Lindsay Family Graduate Scholarship, Canada Research Chairs Program (award number 231397), the Canadian Institutes of Health Research (grant reference numbers 124976, 142738, and 148394), the Brain & Behavior Research Foundation (NARSAD) Independent Investigator Grant 24684, Nova Scotia Health Research Foundation (grants 275319, 1716, and 353892), the Dalhousie Medical Research Foundation, and the Natural Sciences and Engineering Research Council of Canada (grant RGPIN-305). Publisher Copyright: Copyright © 2019 Wescott, Morash-Conway, Zwicker, Cumby, Uher and Rusak. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PY - 2019

Y1 - 2019

N2 - Background: Sleep problems in childhood are an early predictor of mood disorders among individuals at high familial risk. However, the majority of the research has focused on sleep disturbances in already diagnosed individuals and has largely neglected investigating potential differences between weeknight and weekend sleep in high-risk offspring. This study examined sleep parameters in offspring of parents with major depressive disorder or bipolar disorder during both weeknights and weekends. Methods: We used actigraphy, sleep diaries, and questionnaires to measure several sleep characteristics in 73 offspring aged 4-19 years: 23 offspring of a parent with major depressive disorder, 22 offspring of a parent with bipolar disorder, and 28 control offspring. Results: Offspring of parents with major depressive disorder slept, on average, 26 min more than control offspring on weeknights (95% confidence interval, 3 to 49 min, p = 0.027). Offspring of parents with bipolar disorder slept, on average, 27 min more on weekends than on weeknights compared to controls, resulting in a significant family history × weekend interaction (95% confidence interval, 7 to 47 min, p = 0.008). Conclusions: Sleep patterns in children and adolescents were related to the psychiatric diagnosis of their parent(s). Future follow-up of these results may clarify the relations between early sleep differences and the risk of developing mood disorders in individuals at high familial risk.

AB - Background: Sleep problems in childhood are an early predictor of mood disorders among individuals at high familial risk. However, the majority of the research has focused on sleep disturbances in already diagnosed individuals and has largely neglected investigating potential differences between weeknight and weekend sleep in high-risk offspring. This study examined sleep parameters in offspring of parents with major depressive disorder or bipolar disorder during both weeknights and weekends. Methods: We used actigraphy, sleep diaries, and questionnaires to measure several sleep characteristics in 73 offspring aged 4-19 years: 23 offspring of a parent with major depressive disorder, 22 offspring of a parent with bipolar disorder, and 28 control offspring. Results: Offspring of parents with major depressive disorder slept, on average, 26 min more than control offspring on weeknights (95% confidence interval, 3 to 49 min, p = 0.027). Offspring of parents with bipolar disorder slept, on average, 27 min more on weekends than on weeknights compared to controls, resulting in a significant family history × weekend interaction (95% confidence interval, 7 to 47 min, p = 0.008). Conclusions: Sleep patterns in children and adolescents were related to the psychiatric diagnosis of their parent(s). Future follow-up of these results may clarify the relations between early sleep differences and the risk of developing mood disorders in individuals at high familial risk.

UR - http://www.scopus.com/inward/record.url?scp=85068143287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068143287&partnerID=8YFLogxK

U2 - 10.3389/fpsyt.2019.00225

DO - 10.3389/fpsyt.2019.00225

M3 - Article

C2 - 31024367

AN - SCOPUS:85068143287

SN - 1664-0640

VL - 10

JO - Frontiers in Psychiatry

JF - Frontiers in Psychiatry

IS - APR

M1 - 225

ER -

Sleep in offspring of parents with mood disorders

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this