Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis

Gibanananda Ray; Snigdha Banerjee; Neela K. Saxena; Donald R. Campbell; Peter Van Veldhuizen; Sushanta K. Banerjee

doi:10.3892/or.13.3.445

Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis

Gibanananda Ray, Snigdha Banerjee, Neela K. Saxena, Donald R. Campbell, Peter Van Veldhuizen, Sushanta K. Banerjee

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

There was 100% solid tumor formation following inoculation of MCF-7 cells. However, MCF-7 tumor progression was significantly greater in the mice exposed to 17β-estradiol (17β-E2) compared to unexposed mice. WISP-2/CCN5 mRNA expression was correspondingly increased in 17β-E2 exposed MCF-7 tumors compared to unexposed xenografts. Moreover, estrogen exposure followed by antiestrogen tamoxifen treatment drastically inhibited the tumor growth and WISP-2 expression in nude mice. Therefore, the study suggests that higher WISP-2/CCN5 expression by estrogen may be associated with the estrogen-induced growth of MCF-7 tumors in vivo. Finally, overexpression of WISP-2/CCN5 may be considered as a prognostic marker of estrogen-sensitive tumor growth.

Original language	English
Pages (from-to)	445-448
Number of pages	4
Journal	Oncology Reports
Volume	13
Issue number	3
DOIs	https://doi.org/10.3892/or.13.3.445
Publication status	Published - Mar 2005
Externally published	Yes

ASJC Scopus Subject Areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/or.13.3.445

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title = "Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis",

abstract = "There was 100% solid tumor formation following inoculation of MCF-7 cells. However, MCF-7 tumor progression was significantly greater in the mice exposed to 17β-estradiol (17β-E2) compared to unexposed mice. WISP-2/CCN5 mRNA expression was correspondingly increased in 17β-E2 exposed MCF-7 tumors compared to unexposed xenografts. Moreover, estrogen exposure followed by antiestrogen tamoxifen treatment drastically inhibited the tumor growth and WISP-2 expression in nude mice. Therefore, the study suggests that higher WISP-2/CCN5 expression by estrogen may be associated with the estrogen-induced growth of MCF-7 tumors in vivo. Finally, overexpression of WISP-2/CCN5 may be considered as a prognostic marker of estrogen-sensitive tumor growth.",

author = "Gibanananda Ray and Snigdha Banerjee and Saxena, {Neela K.} and Campbell, {Donald R.} and {Van Veldhuizen}, Peter and Banerjee, {Sushanta K.}",

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T1 - Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts

T2 - A novel signaling molecule in hormonal carcinogenesis

AU - Ray, Gibanananda

AU - Banerjee, Snigdha

AU - Saxena, Neela K.

AU - Campbell, Donald R.

AU - Van Veldhuizen, Peter

AU - Banerjee, Sushanta K.

PY - 2005/3

Y1 - 2005/3

N2 - There was 100% solid tumor formation following inoculation of MCF-7 cells. However, MCF-7 tumor progression was significantly greater in the mice exposed to 17β-estradiol (17β-E2) compared to unexposed mice. WISP-2/CCN5 mRNA expression was correspondingly increased in 17β-E2 exposed MCF-7 tumors compared to unexposed xenografts. Moreover, estrogen exposure followed by antiestrogen tamoxifen treatment drastically inhibited the tumor growth and WISP-2 expression in nude mice. Therefore, the study suggests that higher WISP-2/CCN5 expression by estrogen may be associated with the estrogen-induced growth of MCF-7 tumors in vivo. Finally, overexpression of WISP-2/CCN5 may be considered as a prognostic marker of estrogen-sensitive tumor growth.

AB - There was 100% solid tumor formation following inoculation of MCF-7 cells. However, MCF-7 tumor progression was significantly greater in the mice exposed to 17β-estradiol (17β-E2) compared to unexposed mice. WISP-2/CCN5 mRNA expression was correspondingly increased in 17β-E2 exposed MCF-7 tumors compared to unexposed xenografts. Moreover, estrogen exposure followed by antiestrogen tamoxifen treatment drastically inhibited the tumor growth and WISP-2 expression in nude mice. Therefore, the study suggests that higher WISP-2/CCN5 expression by estrogen may be associated with the estrogen-induced growth of MCF-7 tumors in vivo. Finally, overexpression of WISP-2/CCN5 may be considered as a prognostic marker of estrogen-sensitive tumor growth.

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Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signaling molecule in hormonal carcinogenesis

Abstract

ASJC Scopus Subject Areas

UN SDGs

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