Striatonigral projection neurons contain D1 dopamine receptor-activated c-fos

G. S. Robertson; S. R. Vincent; H. C. Fibiger

doi:10.1016/0006-8993(90)91498-6

Striatonigral projection neurons contain D₁ dopamine receptor-activated c-fos

G. S. Robertson, S. R. Vincent, H. C. Fibiger

Research output: Contribution to journal › Article › peer-review

159 Citations (Scopus)

Abstract

Dopamine receptor agonists which stimulate the D₁ receptor have been shown to activate c-fos in the striatum ipsilateral to a 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal pathway. In the present study, striatal neurons ipsilateral to a 6-OHDA lesion of the medial forebrain bundle were retrogradely labelled by injection of the fluorescent tracer Fluoro-Gold into the substantia nigra pars reticulata. Five days later, c-fos was induced in the 6-OHDA-denervated striatum by injection of the selective D₁ agonist SKF 38393. C-fos-positive nuclei were frequently found in medium-sized striatal cell bodies labelled with Fluoro-Gold. These results indicate that D₁ agonists activate c-fos in medium-sized neurons that project to the substantia nigra pars reticulata.

Original language	English
Pages (from-to)	288-290
Number of pages	3
Journal	Brain Research
Volume	523
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(90)91498-6
Publication status	Published - Jul 23 1990
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the Medical Research Council of Canada PG-(23). G.S.R. is an MRC Fellow, and S.R.V. an MRC scientist. The authors thank Ms. Ester Leung for excellent technical assistance.

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(90)91498-6

Cite this

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title = "Striatonigral projection neurons contain D1 dopamine receptor-activated c-fos",

abstract = "Dopamine receptor agonists which stimulate the D1 receptor have been shown to activate c-fos in the striatum ipsilateral to a 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal pathway. In the present study, striatal neurons ipsilateral to a 6-OHDA lesion of the medial forebrain bundle were retrogradely labelled by injection of the fluorescent tracer Fluoro-Gold into the substantia nigra pars reticulata. Five days later, c-fos was induced in the 6-OHDA-denervated striatum by injection of the selective D1 agonist SKF 38393. C-fos-positive nuclei were frequently found in medium-sized striatal cell bodies labelled with Fluoro-Gold. These results indicate that D1 agonists activate c-fos in medium-sized neurons that project to the substantia nigra pars reticulata.",

author = "Robertson, {G. S.} and Vincent, {S. R.} and Fibiger, {H. C.}",

note = "Funding Information: This work was supported by the Medical Research Council of Canada PG-(23). G.S.R. is an MRC Fellow, and S.R.V. an MRC scientist. The authors thank Ms. Ester Leung for excellent technical assistance.",

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N2 - Dopamine receptor agonists which stimulate the D1 receptor have been shown to activate c-fos in the striatum ipsilateral to a 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal pathway. In the present study, striatal neurons ipsilateral to a 6-OHDA lesion of the medial forebrain bundle were retrogradely labelled by injection of the fluorescent tracer Fluoro-Gold into the substantia nigra pars reticulata. Five days later, c-fos was induced in the 6-OHDA-denervated striatum by injection of the selective D1 agonist SKF 38393. C-fos-positive nuclei were frequently found in medium-sized striatal cell bodies labelled with Fluoro-Gold. These results indicate that D1 agonists activate c-fos in medium-sized neurons that project to the substantia nigra pars reticulata.

AB - Dopamine receptor agonists which stimulate the D1 receptor have been shown to activate c-fos in the striatum ipsilateral to a 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal pathway. In the present study, striatal neurons ipsilateral to a 6-OHDA lesion of the medial forebrain bundle were retrogradely labelled by injection of the fluorescent tracer Fluoro-Gold into the substantia nigra pars reticulata. Five days later, c-fos was induced in the 6-OHDA-denervated striatum by injection of the selective D1 agonist SKF 38393. C-fos-positive nuclei were frequently found in medium-sized striatal cell bodies labelled with Fluoro-Gold. These results indicate that D1 agonists activate c-fos in medium-sized neurons that project to the substantia nigra pars reticulata.

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