Structural investigation of bacterial lipopolysaccharides by mass spectrometry and tandem mass spectrometry

Joseph H. Banoub, Anas El Aneed, Alejandro M. Cohen, Nicolas Joly

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

Mass spectrometric studies are now playing a leading role in the elucidation of lipopolysaccharide (LPS) structures through the characterization of antigenic polysaccharides, core oligosaccharides and lipid A components including LPS genetic modifications. The conventional MS and MS/MS analyses together with CID fragmentation provide additional structural information complementary to the previous analytical experiments, and thus contribute to an integrated strategy for the simultaneous characterization and correct sequencing of the carbohydrate moiety.

Original languageEnglish
Pages (from-to)606-650
Number of pages45
JournalMass Spectrometry Reviews
Volume29
Issue number4
DOIs
Publication statusPublished - 2010
Externally publishedYes

ASJC Scopus Subject Areas

  • Analytical Chemistry
  • Condensed Matter Physics
  • General Biochemistry,Genetics and Molecular Biology
  • Spectroscopy

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