Suppression of IgE antibody formation in mice: Requirement for T-T lymphocyte interaction

J. Ngan, L. S. Kind

Research output: Contribution to journalArticlepeer-review

Abstract

Normal SWR mice injected syngeneic spleen cells from ovalbumin (Ov)-primed mice were unable to make IgE anti-Ov antibodies when challenged with alum-pertussis Ov. Immune T lymphocytes were shown to be responsible for the inhibitory effects of adoptively transferred spleen cells. Treatment of recipient mice with mild x-irradiation or with cyclophosphamide 2 or 3 days before cell transfer resulted in abrogation of the suppressor effect of immune cells. The injection of T lymphocytes into x irradiated mice restored the suppressive effect of immune cells. It thus appears that immune T cells provide the stimulus for activation of suppressor T cells of the host. Although the generation of suppression is antigen specific, the expression of suppression appears to be non specific.

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalInternational Archives of Allergy and Applied Immunology
Volume58
Issue number2
DOIs
Publication statusPublished - 1979

ASJC Scopus Subject Areas

  • Immunology and Allergy

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