Suppression of the inductive effects of phenobarbital and 3-methylcholanthrene on ascorbic acid synthesis and hepatic cytochrome P-450-linked monooxygenase systems by the interferon inducers, poly rI·rC and tilorone

Kenneth W. Renton; Daniel E. Keyler; Gilbert J. Mannering

doi:10.1016/0006-291X(79)91510-9

Suppression of the inductive effects of phenobarbital and 3-methylcholanthrene on ascorbic acid synthesis and hepatic cytochrome P-450-linked monooxygenase systems by the interferon inducers, poly rI·rC and tilorone

Kenneth W. Renton, Daniel E. Keyler, Gilbert J. Mannering

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The interferon inducing agents, poly rI·rC and tilorone, cause a marked depression of hepatic cytochrome P-450-linked monooxygenase systems. Ascorbate synthesis and hepatic monnoxygenase systems are induced by phenobarbital and 3-methylcholanthrene. Poly rI·rC and tilorone suppressed the induction of ascorbate synthesis, P-450 and monooxygenase activity (ethylmorphine N-demethylase and benzo[a]pyrene hydroxylase) by phenobarbital. 3-Methylcholanthrene-induced ascorbate synthesis was suppressed by poly rI·rC, but equivocal results were obtained with tilorone. Induction of P-450 by 3-methylcholanthrene was suppressed completely by poly rI·rC or tilorone, but that of benzo[a]pyrene hydroxylase was lowered by only 40%, thus demonstrating the selective depressive action of interferon inducing agents on different species of P-450.

Original language	English
Pages (from-to)	1017-1023
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	88
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(79)91510-9
Publication status	Published - Jun 13 1979
Externally published	Yes

Bibliographical note

Funding Information:
1Recipient of a fellowship from the Medical Research Council of Canada. Present address: Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H6. 2Abbreviations: Poly rI*rC or IC, polyriboinosinic acid - polyribo-cytidylic acid; MC, 3-methylcholanthrene; PB, phenobarbital; BP, benzo[a]-pyrene; EM, ethylmorphine.

ASJC Scopus Subject Areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Renton, K. W., Keyler, D. E., & Mannering, G. J. (1979). Suppression of the inductive effects of phenobarbital and 3-methylcholanthrene on ascorbic acid synthesis and hepatic cytochrome P-450-linked monooxygenase systems by the interferon inducers, poly rI·rC and tilorone. Biochemical and Biophysical Research Communications, 88(3), 1017-1023. https://doi.org/10.1016/0006-291X(79)91510-9

Suppression of the inductive effects of phenobarbital and 3-methylcholanthrene on ascorbic acid synthesis and hepatic cytochrome P-450-linked monooxygenase systems by the interferon inducers, poly rI·rC and tilorone. / Renton, Kenneth W.; Keyler, Daniel E.; Mannering, Gilbert J.
In: Biochemical and Biophysical Research Communications, Vol. 88, No. 3, 13.06.1979, p. 1017-1023.

Research output: Contribution to journal › Article › peer-review

Renton, KW, Keyler, DE & Mannering, GJ 1979, 'Suppression of the inductive effects of phenobarbital and 3-methylcholanthrene on ascorbic acid synthesis and hepatic cytochrome P-450-linked monooxygenase systems by the interferon inducers, poly rI·rC and tilorone', Biochemical and Biophysical Research Communications, vol. 88, no. 3, pp. 1017-1023. https://doi.org/10.1016/0006-291X(79)91510-9

Renton, Kenneth W. ; Keyler, Daniel E. ; Mannering, Gilbert J. / Suppression of the inductive effects of phenobarbital and 3-methylcholanthrene on ascorbic acid synthesis and hepatic cytochrome P-450-linked monooxygenase systems by the interferon inducers, poly rI·rC and tilorone. In: Biochemical and Biophysical Research Communications. 1979 ; Vol. 88, No. 3. pp. 1017-1023.

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abstract = "The interferon inducing agents, poly rI·rC and tilorone, cause a marked depression of hepatic cytochrome P-450-linked monooxygenase systems. Ascorbate synthesis and hepatic monnoxygenase systems are induced by phenobarbital and 3-methylcholanthrene. Poly rI·rC and tilorone suppressed the induction of ascorbate synthesis, P-450 and monooxygenase activity (ethylmorphine N-demethylase and benzo[a]pyrene hydroxylase) by phenobarbital. 3-Methylcholanthrene-induced ascorbate synthesis was suppressed by poly rI·rC, but equivocal results were obtained with tilorone. Induction of P-450 by 3-methylcholanthrene was suppressed completely by poly rI·rC or tilorone, but that of benzo[a]pyrene hydroxylase was lowered by only 40%, thus demonstrating the selective depressive action of interferon inducing agents on different species of P-450.",

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N2 - The interferon inducing agents, poly rI·rC and tilorone, cause a marked depression of hepatic cytochrome P-450-linked monooxygenase systems. Ascorbate synthesis and hepatic monnoxygenase systems are induced by phenobarbital and 3-methylcholanthrene. Poly rI·rC and tilorone suppressed the induction of ascorbate synthesis, P-450 and monooxygenase activity (ethylmorphine N-demethylase and benzo[a]pyrene hydroxylase) by phenobarbital. 3-Methylcholanthrene-induced ascorbate synthesis was suppressed by poly rI·rC, but equivocal results were obtained with tilorone. Induction of P-450 by 3-methylcholanthrene was suppressed completely by poly rI·rC or tilorone, but that of benzo[a]pyrene hydroxylase was lowered by only 40%, thus demonstrating the selective depressive action of interferon inducing agents on different species of P-450.

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Suppression of the inductive effects of phenobarbital and 3-methylcholanthrene on ascorbic acid synthesis and hepatic cytochrome P-450-linked monooxygenase systems by the interferon inducers, poly rI·rC and tilorone

Abstract

Bibliographical note

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