Target-based selection of flavonoids for neurodegenerative disorders

Quinton R.D. Jones, Jordan Warford, H. P.Vasantha Rupasinghe, George S. Robertson

Research output: Contribution to journalReview articlepeer-review

100 Citations (Scopus)

Abstract

Habitual consumption of dietary flavonoids known to improve mitochondrial bioenergetics and inhibit various secondary sources of reactive oxygen species (ROS) reduces the risk for neurodegenerative disorders such as Parkinson's disease (PD), stroke, and Alzheimer's disease (AD). Combining specific dietary flavonoids selected on the basis of oral bioavailability, brain penetration, and the inhibition of multiple processes responsible for excessive ROS production may be a viable approach for the prevention and treatment of neurodegenerative disorders. Inclusion of flavonoids that raise cAMP levels in the brain may be of additional benefit by reducing the production of proinflammatory mediators and stimulating the transcriptional machinery necessary for mitochondrial biosynthesis. Preclinical models suggest that flavonoids reduce hearing loss resulting from treatment with the chemotherapeutic drug cisplatin by opposing the excessive production of ROS and proinflammatory mediators implicated in PD, stroke, and AD. Flavonoid combinations optimized for efficacy in models of cisplatin-induced hearing loss (CIHL) may therefore have therapeutic utility for neurodegenerative disorders.

Original languageEnglish
Pages (from-to)602-610
Number of pages9
JournalTrends in Pharmacological Sciences
Volume33
Issue number11
DOIs
Publication statusPublished - Nov 2012

ASJC Scopus Subject Areas

  • Toxicology
  • Pharmacology

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