Targeted Metabolic Reprogramming to Improve the Efficacy of Oncolytic Virus Therapy

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21 Citations (Scopus)

Abstract

Oncolytic viruses (OVs) represent a promising new class of cancer therapeutics and cause antitumor effects by two major mechanisms: (1) directly killing cancer cells in a process known as oncolysis, or (2) initiating a powerful antitumor immune response. Interestingly, energy metabolism, within either cancer cells or immune cells, plays a pivotal role in defining the outcome of OV-mediated antitumor effects. Following therapeutic administration, OVs must hijack host cell metabolic pathways to acquire building blocks such as nucleotides, lipids, and amino acids for the process of replication that is necessary for oncolysis. Additionally, OV-stimulated antitumor immune responses are highly dependent on the metabolic state within the tumor microenvironment. Thus, metabolic reprogramming strategies bear the potential to enhance the efficacy of both OV-mediated oncolysis and antitumor immune responses.

Original languageEnglish
Pages (from-to)1417-1421
Number of pages5
JournalMolecular Therapy
Volume28
Issue number6
DOIs
Publication statusPublished - Jun 3 2020

Bibliographical note

Publisher Copyright:
© 2020 The American Society of Gene and Cell Therapy

ASJC Scopus Subject Areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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