Teratogenesis of holoprosencephaly

M. Michael Cohen; Kohei Shiota

doi:10.1002/ajmg.10258

Teratogenesis of holoprosencephaly

M. Michael Cohen, Kohei Shiota

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

165 Citations (Scopus)

Abstract

Teratogenic causes of holoprosencephaly are critically assessed. A brief general review of holoprosencephaly is followed by four tables summarizing etiologic factors. Subjects evaluated here include: 1) maternal diabetes; 2) ethyl alcohol; 3) retinoic acid; 4) mutated genes and teratogens involving the sonic hedgehog signaling network and cholesterol biosynthesis; and 5) cholesterol trafficking, sterol adducts, target tissue response, and sterol sensing domain.

Original language	English
Pages (from-to)	1-15
Number of pages	15
Journal	American Journal of Medical Genetics
Volume	109
Issue number	1
DOIs	https://doi.org/10.1002/ajmg.10258
Publication status	Published - Apr 15 2002

ASJC Scopus Subject Areas

Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ajmg.10258

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abstract = "Teratogenic causes of holoprosencephaly are critically assessed. A brief general review of holoprosencephaly is followed by four tables summarizing etiologic factors. Subjects evaluated here include: 1) maternal diabetes; 2) ethyl alcohol; 3) retinoic acid; 4) mutated genes and teratogens involving the sonic hedgehog signaling network and cholesterol biosynthesis; and 5) cholesterol trafficking, sterol adducts, target tissue response, and sterol sensing domain.",

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AB - Teratogenic causes of holoprosencephaly are critically assessed. A brief general review of holoprosencephaly is followed by four tables summarizing etiologic factors. Subjects evaluated here include: 1) maternal diabetes; 2) ethyl alcohol; 3) retinoic acid; 4) mutated genes and teratogens involving the sonic hedgehog signaling network and cholesterol biosynthesis; and 5) cholesterol trafficking, sterol adducts, target tissue response, and sterol sensing domain.

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Teratogenesis of holoprosencephaly

Abstract

ASJC Scopus Subject Areas

UN SDGs

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