Testing the PPAR hypothesis of tobacco use disorder in humans: A randomized trial of the impact of gemfibrozil (a partial PPARα agonist) in smokers

Agriculture & Biology

• gemfibrozil 95%
• tobacco use 88%
• peroxisome proliferator-activated receptors 83%
• cigarettes 69%
• agonists 53%
• placebos 35%
• testing 22%
• nicotine 19%
• craving 13%
• smoking (habit) 10%
• cross-over studies 9%
• clinical trials 8%
• animal behavior 8%
• physiological response 8%
• drug therapy 8%
• methodology 2%

Medicine & Life Sciences

• Gemfibrozil 84%
• Tobacco Use Disorder 70%
• Peroxisome Proliferator-Activated Receptors 69%
• Tobacco Products 54%
• Smokers 48%
• Placebos 22%
• Cues 21%
• Nicotine 16%
• Smoking 11%
• Tobacco Use Cessation 11%
• Animal Behavior 10%
• PPAR alpha 10%
• Self Administration 9%
• Craving 9%
• Tobacco Smoking 9%
• Cross-Over Studies 7%
• Clinical Studies 5%
• Therapeutics 1%

Chemical Compounds

• Peroxisome Proliferator Activated Receptor Agonist 100%
• Gemfibrozil 91%
• Disorder 49%
• Nicotine 11%