The anti-malarial drug artesunate causes cell cycle arrest and apoptosis of triple-negative MDA-MB-468 and HER2-enriched SK-BR-3 breast cancer cells

Medicine & Life Sciences

• Breast Cancer 3 90%
• Artesunate 87%
• Antimalarials 68%
• Epidermal Growth Factor 60%
• Cell Cycle Checkpoints 60%
• Apoptosis 37%
• Pharmaceutical Preparations 25%
• Breast Neoplasms 17%
• Reactive Oxygen Species 16%
• Artemisia annua 11%
• artemisinine 8%
• Mitochondrial Membranes 7%
• Malaria 6%
• Iron 5%
• Cell Death 5%
• Poisons 5%
• Oxidative Stress 5%
• Cell Proliferation 4%
• Neoplasms 4%
• Morbidity 4%
• Drug Therapy 4%
• DNA 3%
• Growth 3%
• Mortality 3%
• Therapeutics 3%

Chemical Compounds

• Artesunate 100%
• Antimalarial 74%
• Drug 32%
• Anticytotoxic 14%
• Semisynthetic Derivative 13%
• Apoptotic 10%
• Cell Death 9%
• Antiproliferative 8%
• Oxidative Stress 8%
• Dioxygen 8%
• Reactive Oxygen Metabolite 8%
• Antineoplastic Agent 7%
• Toxic 6%